
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 31, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 31, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(48)
Published: Aug. 16, 2024
Abstract The rising prospects of mechanochemically assisted syntheses hold promise for both academia and industry, yet they face challenges in understanding and, therefore, anticipating respective reaction kinetics. Particularly, dependencies based on variations milling equipment remain little understood globally overlooked. This study aims to address this issue by identifying critical parameters through kinematic models, facilitating the reproducibility mechanochemical reactions across most prominent mills laboratory settings, namely planetary mixer mills. Through a series selected experiments replicating major classes organic, organometallic, transition metal‐catalyzed, inorganic from literature, we rationalize independence kinetics when accumulated energy criterion is met. As step forward facilitate practicability our findings, provide freely accessible online tool [†] that allows calculation different Our work advances current mechanochemistry lays foundation future rational exploration rapidly evolving field.
Language: Английский
Citations
9RSC Mechanochemistry, Journal Year: 2024, Volume and Issue: 1(1), P. 43 - 49
Published: Jan. 1, 2024
Through thermo-mechanochemical conditions it is possible to generate metastable crystal forms below equilibrium thermodynamic transition temperatures, making thermo-mechanical an exciting new direction for solid form control.
Language: Английский
Citations
7Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(9), P. 2035 - 2043
Published: Feb. 8, 2024
Abstract Our research has demonstrated that mechanochemical activation is more effective with solid reagents. We have showcased the practicality of Bertagnini's salts, also called aldehyde‐bisulfite adducts, which are crystalline, simplifying preparation and storage. These salts stable substitutes for liquid aldehydes ketones been employed in reductive amination, synthesizing aza‐heterocycles hydrazones within mechanochemistry. The technique‘s effectiveness broadens substrate scopes, simplifies purification, reduces reaction times, yields desired products ranging from 38–91%. Additionally, thermal stability bisulfite adducts confirmed through TGA (Thermogravimetric analysis) analysis.
Language: Английский
Citations
3Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
In this contribution, we apply our newly developed ball-milling operando platform, which combines Raman spectroscopy and thermal (IR) imaging, as well acoustic high-speed optical video recordings, to the synthesis transformation of citric acid–isonicotinamide (1:2) cocrystal polymorphs in transparent PMMA jars. Particularly, demonstrate how Raman, temperature, acoustic, data are complementary enable detection connection chemical physical events happening during a time-resolved manner. Importantly, show that formation three can be detected through analyses solely. Even more impressively, meticulous sound allowed subtle polymorphic transitions perceived mode when was not conclusive enough. Such changes signatures greatly linked beads' motions milling jar. A new analysis methodology recordings is proposed combination energetic statistical approaches simplifies for potential users. The interpretation signals further validated thanks videos recorded synchronization with all other techniques. Finally, broaden opaque stainless-steel jars, showing relevance method following transformations cocrystals, pure substances, any type
Language: Английский
Citations
0Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 15 - 51
Published: Jan. 1, 2025
Language: Английский
Citations
0Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
With the rapid increase in temperatures around planet, need to develop efficient means reduce CO2 emissions has become one of greatest challenges scientific community. Many different strategies are being studied worldwide, which consists trapping gas porous materials, either for its short- or long-term capture and storage, re-use production value-added compounds. Yet, further development such systems, there is a real fully understand their structure properties, including at molecular-level following physisorption and/or chemisorption (which can lead various species, carbonate bicarbonate ions). In this context, 17O NMR naturally appears as analytical tool choice, because exquisite sensitivity probe subtle differences oxygen bonding environments. To date, it scarcely been used, due very low natural abundance (0.04%), difficulty purchasing obtaining commercial 17O-labeled compounds adapted investigations (e.g., 17O-CO2(g), 17O-enriched Na- K-(bi)carbonate salts, be readily transformed into CO2). Herein, we demonstrate how, using mechanochemistry, possible enrich with variety salts fast, economical, scalable, user-friendly way. The high enrichment levels enabled recording first high-resolution ssNMR spectra these phases magnetic fields. From these, typical spectral signatures (bi)carbonate ions could obtained, showing strong local environments dynamics. Lastly, show how thanks selective 17O-labeling, other aspects reactivity carbonates materials unveiled situ ssNMR. long run, expected that work will open way more profound properties carbon storage and, generally speaking, functional containing carbonates.
Language: Английский
Citations
0Nature Reviews Methods Primers, Journal Year: 2025, Volume and Issue: 5(1)
Published: May 22, 2025
Language: Английский
Citations
0Chemical Communications, Journal Year: 2023, Volume and Issue: 59(90), P. 13490 - 13493
Published: Jan. 1, 2023
We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators additives. Non-covalent interactions between reagents guide formation amide bond.
Language: Английский
Citations
8RSC Mechanochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 31, 2024
An effective and fast solvent-free mechanochemical racemization of an API by controlling experimental key parameters.
Language: Английский
Citations
1Published: July 25, 2024
Albeit mechanochemistry is a novel promising technology that give access to reactivity under solvent-free conditions, heating such reactions sometimes compulsory obtain satisfactory results in terms of conversion, selectivity and/or yield. In this work, we developed approach using dye absorbs NIR photons and release the energy as heat. Hence, milling jars epoxy resin doped with were thus produced reactors would produce heat upon irradiation at 850 nm. Temperature profiles recorded, depending on irradiance, charge resin, frequency, showing an excellent control temperature. The usefulness jar was then demonstrated mechanochemical are known require yield desired product, namely Diels-Alder high activation energies newly rearrangement sydnone into corresponding 1,3,4- oxadiazolin-2-one.
Language: Английский
Citations
0