A
thermal-responsive
antibacterial
nanocomposite
(HMSN-AuNC)
was
developed
by
the
integration
of
photodynamic
gold
nanoclusters
(AuNCs)
and
a
hollow
mesoporous
silica
nanoparticle
modified
with
thermo-responsive
polymers
(HMSN-PNIPAM).
The
ultrasmall-sized
AuNCs
matched
well
pore
size
HMSN,
thus
allowing
for
diffusing
into
out
cavity
HMSN-PNIPAM.
grafted
PNIPAM
underwent
reversible
phase
transition
at
varied
temperature,
which
accompanied
change
its
apparent
volume,
realizing
switch-on/off
HMSN
pores
effectively
loading
releasing
AuNCs.
Under
light
irradiation,
in
HMSN-AuNC
could
be
released
generate
reactive
oxygen
species,
then
perform
bacteria
killing.
Therefore,
taking
advantages
thermo-responsiveness
property
AuNCs,
exhibited
"switching"
effect
on
performance
realized
controlled
manner.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(7), P. 1574 - 1574
Published: April 1, 2024
Gold
nanoclusters
(Au
NCs)
with
bright
emission
and
unique
chemical
reactivity
characters
have
been
widely
applied
for
optical
sensing
imaging.
With
a
combination
of
surface
modifications,
effective
therapeutic
treatments
tumors
are
realized.
In
this
review,
we
summarize
the
recently
adopted
biosensing
therapy
events
based
on
Au
NCs.
Homogeneous
fluorometric
systems
toward
various
targets,
including
ions,
small
molecules,
reactive
oxygen
species,
biomacromolecules,
cancer
cells,
bacteria,
in
vitro
vivo,
presented
by
turn-off,
turn-on,
ratiometric
tactics.
The
applications
concluded
three
aspects:
photodynamic
therapy,
photothermal
as
drug
carrier.
basic
mechanisms
performances
these
introduced.
Finally,
review
highlights
challenges
future
trend
NC-based
systems.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(8), P. 226 - 226
Published: Aug. 14, 2024
This
review
explores
the
latest
advancements
in
nanoporous
materials
and
their
applications
biomedical
imaging
diagnostics.
Nanoporous
possess
unique
structural
features,
including
high
surface
area,
tunable
pore
size,
versatile
chemistry,
making
them
highly
promising
platforms
for
a
range
of
applications.
begins
by
providing
an
overview
various
types
materials,
mesoporous
silica
nanoparticles,
metal–organic
frameworks,
carbon-based
gold.
The
synthesis
method
each
material,
current
research
trends,
prospects
are
discussed
detail.
Furthermore,
this
delves
into
functionalization
modification
techniques
employed
to
tailor
specific
section
covers
chemical
functionalization,
bioconjugation
strategies,
coating
encapsulation
methods.
Additionally,
examines
diverse
enabled
such
as
fluorescence
imaging,
magnetic
resonance
(MRI),
computed
tomography
(CT)
ultrasound
multimodal
imaging.
mechanisms
underlying
these
techniques,
diagnostic
applications,
efficacy
clinical
settings
thoroughly
explored.
Through
extensive
analysis
recent
findings
emerging
underscores
transformative
potential
advancing
integration
interdisciplinary
approaches,
innovative
strategies
offers
avenues
development
next-generation
agents
tools
with
enhanced
sensitivity,
specificity,
biocompatibility.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
Gold
nanoclusters
emitting
in
the
second
biological
window
(NIR-II-AuNCs)
have
gained
significant
interest
for
their
potential
deep-tissue
bioimaging
and
biosensing
applications
due
to
partial
transparency
reduced
autofluorescence
of
tissues
this
spectral
range.
However,
limited
understanding
how
environment
affects
luminescent
properties
might
hinder
use
biosensing.
In
study,
we
investigated
emission
NIR-II-AuNCs
when
interacting
internalizing
into
live
cells
including
macrophages,
fibroblasts,
cancer
cell
lines,
revealing
substantial
alterations
luminescence.
A
systematic
comparison
between
control
vitro
experiments
concluded
that
disruption
surface
ligands
is
main
factor
responsible
these
alterations.
within
cellular
environments
may
also
be
influenced
by
other
interactions,
aggregation
or
complexation
with
proteins.
Furthermore,
corroborated
spectroscopic
modifications
at
vivo
level,
providing
additional
evidence
environmental
sensitivity
NIR-II-AuNCs.
The
results
obtained
study
contribute
a
deeper
luminescence
mechanisms
living
are
crucial
optimization
as
reliable
tools
imaging
diagnostics.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 89 - 89
Published: March 5, 2025
Background:
Fluorescent
gold
nanoclusters
conjugated
with
α-lipoic
acid
(FANCs)
have
shown
great
promise
for
drug
development.
In
a
previous
study,
FANCs
did
not
show
any
acute
or
subacute
toxicity
under
0.6–20
μM/100
μL/25
g
body
weight
in
male
and
female
ICR
mice.
However,
the
chronic
of
has
been
studied.
Aim
study:
This
study
used
oral
administration
to
determine
long-term
safety
profile
adverse
effects
Methods:
vivo
was
examined
via
The
daily
food
consumption,
weight,
hematological
profile,
serum
biochemical
organ
coefficient,
histopathological
changes,
survival
rate
mice
were
calculated.
Results:
result
mortality
due
both
animal
behavior,
coefficient
showed
no
treatment-related
malignant
changes.
indicates
that
do
cause
liver,
renal,
other
damage.
Conclusions:
These
results
indicate
no-observed-adverse-effect
level
(NOAEL)
is
20
6
months
treatment
