Nano/micro-plastic, an invisible threat getting into the brain

Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142380 - 142380

Published: May 18, 2024

Due to weather and working/operational conditions, plastic degradation produces toxic non-biodegradable nano microplastics (N/M-Ps, ranging from 10 nm 5 mm), over time these N/M-Ps have integrated with the human cycle through ingestion inhalation. These N/M-Ps, as serious emerging pollutants, are causing considerable adverse health issues due up-taken by cells, tissue, organs, including brain. It has been proven that can cross blood-brain barrier (via olfactory blood vessels) affect secretion of neuroinflammatory (cytokine chemokine), transporters, receptor markers. Neurotoxicity, neuroinflammation, brain injury, which may result in such scenarios a concern cause disorders. However, related pathways pathogenesis not well-explored but focus upcoming research. Therefore, this editorial, well-organized multidisciplinary research is required explore associated pathogenesis, leading mapping nano-enabled therapeutics acute chronic N/M-P exposure.

Language: Английский

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Naphthalene peri-Diselenide-Based BODIPY Probe for the Detection of Hydrogen Peroxide, tert-Butylhydroperoxide, Hydroxyl Radical, and Peroxynitrite Ion

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6396 - 6405

Published: Feb. 13, 2025

Dimethoxynaphthalene peri-diselenide-based BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) probe has been synthesized. The demonstrated selectivity and sensitivity for hydrogen peroxide (H2O2) tert-butylhydroperoxide (t-BuOOH), hydroxyl radical (•OH), peroxynitrite ion (ONOO–) detection reversibility upon treatment with glutathione. limits of the were observed to be 0.40 μM H2O2, 0.41 t-BuOOH, 0.95 •OH, 0.46 ONOO–, respectively. A proposed mechanism "turn-on" event suggested corroborated by spectroscopic computational data. It that electron transfer occurred from Se center moiety, followed photoinduced (PET) mechanism.

Language: Английский

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Synthesis and structural studies of 1-naphthyl and mesityl ligand bearing organotellurium(II and IV) derivatives

Polyhedron, Journal Year: 2025, Volume and Issue: unknown, P. 117463 - 117463

Published: Feb. 1, 2025

Language: Английский

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Pyrene‐diaminomaleonitrile‐based fluorescent probe for the turn‐on detection and bioimaging of hypochlorite

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Hypochlorous acid (HClO), a key member of the reactive oxygen species, has an impact on both normal and abnormal functioning wide range organisms. To deeply investigate function HClO in organisms its health status, there is urgent need to develop efficient detection techniques biomedical field. Herein, highly selective sensitive hypochlorite fluorescent probe ( Py‐DA ) was designed synthesized. Photophysical property tests response behavior studies showed high‐performance turn‐on HClO/ClO − , including fast response, high sensitivity, excellent selectivity, strong anti‐interference capabilities. Significantly, emission intensity good linear relationship with concentration 0–30.0 μM, limit as low 37.8 nM. In addition, convenient on‐site rapid (∼1 s) visual identification aqueous also realized via ‐based paper strips. Furthermore, photo‐stability cytotoxicity been successfully applied for imaging human cervical cancer cells (HeLa). The results this study provide new ideas further investigation physiological pathological effects HClO.

Language: Английский

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Oxidation-Controlled, Strain-Promoted Tellurophene-Alkyne Cycloaddition (OSTAC): A Bioorthogonal Tellurophene-Dependent Conjugation Reaction

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Tellurophene-bearing small molecules have emerged as valuable tools for localizing cellular activities

Language: Английский

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Exploring the Te(II)/Te(IV) Redox Couple of a Tellurorosamine Chromophore: Photophysical, Photochemical, and Electrochemical Studies

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(29), P. 13157 - 13165

Published: July 11, 2024

A tellurorosamine dye [

Language: Английский

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Bioinspired Composite Materials with Amplified Clusteroluminescence: Chemodosimetric Interaction Targeting Hypochlorite in Aqueous Medium

ACS Materials Au, Journal Year: 2024, Volume and Issue: 5(2), P. 308 - 319

Published: Dec. 13, 2024

Owing to the advantages of cellulose such as exceptional biocompatibility and biodegradability, we synthesized cellulose-grafted bisindolyl methane (BIM) (1. Cell) composite. This biobased smart material was used an effective colorimetric fluorescent sensor for hypochlorite in aqueous medium with a detection limit 0.02 μM. Interestingly, exhibited inherent clusteroluminescence solution, which further intensified by probe acting dopant. Both boronic acid bisindole groups 1 are essential this enhanced fluorescence, enables boronate ester formation cellulose, while facilitate additional hydrogen bonding interactions. unique dual functionality produces strong, solution-phase clusteroluminescent effect, creating rigid microenvironment that promotes long-range exciton migration amplified fluorescence response. Furthermore, 1. Cell ∼2.8-fold quenching, alone negligible change presence hypochlorite. Mechanistic investigation reveals formed via interaction subsequently cleaved The differences response might be attributed distinct nature their self-assemblies; could form highly ordered aggregates, resulted spontaneous random aggregates. Additionally, employed paper strips explore practicability paper-based sensor. chemically modified strips, grafted molecules, were found stable week effectively detect interfering analytes naked eye color-changing

Language: Английский

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Synthesis and Single Crystal X-Ray Studies of 1-Naphthyl and Mesityl Ligand Bearing Organotellurium (Ii/Iv) Derivatives

Published: Jan. 1, 2024

Language: Английский

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