Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156383 - 156383
Published: Oct. 1, 2024
Language: Английский
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The primary objective of neoantigen vaccines is to elicit a robust anti-tumor immune response by generating neoantigen-specific T cells that can eradicate tumor cells. Despite substantial advancements in personalized prediction using next-generation sequencing, machine learning, and mass spectrometry, challenges remain efficiently expanding cell populations vivo. This challenge impedes the widespread clinical application vaccines. Nanovector-based delivery systems have emerged as promising solutions this challenge. These nanovectors offer several advantages, such enhanced stability, targeted intracellular delivery, sustained release, improved antigen-presenting (APC) activation. Notably, they effectively deliver various vaccine formulations (DC cell-based, synthetic long peptide (SLP)-based or DNA/mRNA-based) APCs cells, thereby activating both CD4+ CD8+ ultimately induces specific response. review focuses on recent innovations vectors. We aim identify optimal design parameters for vectors tailored different types, with an emphasis enhancing microenvironment stimulating production cytotoxic By maximizing potential these systems, we accelerate translation nanovaccines advance cancer immunotherapy.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract The efficacy of in situ cancer vaccines (ISCVs) is hindered by the poor immunogenicity tumor cells. Here, PRIZE, a P53‐repair nanosystem based on virus‐mimicking nanostructure to deliver p53 mRNA and Zn (II) into cells, domesticating cells restoring intracellular P53 levels bolster their immunogenicity, designed. PRIZE ensures precise delivery sites, stabilizes with its biomineralized structure, extends half‐life P53. This research highlights that can efficiently repair abnormalities 4T1 (P53‐deficient) MC38 (P53‐mutant) subsequently upregulating expression major histocompatibility complex (MHC) class I molecules surface co‐stimulatory molecule CD80 enhancing antigen presentation transforming reservoirs. co‐delivered photothermal agent (ICG) trigger immunogenic cell death under laser irradiation, effectively releasing tumor‐associated antigens, inducing formation ISCVs. Importantly, abnormal mouse models, induced ISCVs initiate immune cycle (CIC), demonstrating outstanding tumoricidal immunity thwarting metastasis postoperative recurrence, which provides valuable insights for advancing personalized immunotherapy.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125508 - 125508
Published: March 1, 2025
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111232 - 111232
Published: April 1, 2025
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: May 7, 2025
Cancer immunotherapies have transformed oncology by utilizing the immune system to target malignancies; however, limitations in efficacy and potential side effects remain significant challenges. Nanoparticles shown promise enhancing drug delivery improving activation, with for numerous modifications tailor them specific environments or targets. Integrating nanoplatforms offers a promising avenue overcome these hurdles, treatment outcomes reducing adverse effects. By delivery, targeting, modulation, can unlock full of cancer immunotherapy. This review explores role addressing immunotherapy outcomes, examining various types nanoplatforms. Understanding mechanisms immunomodulation through nanoplatform deliveries is crucial. We discuss how interact tumor microenvironment, modulate tumor-associated macrophages regulatory T cells, activate cells directly, enhance antigen presentation, promote immunological memory. Further benefits include combination approaches integrating chemotherapy, radiotherapy, phototherapy. Immunotherapy relatively new approach, but clinical studies already utilize nanoplatform-based results. aims provide insights into pave way more effective personalized strategies.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: 322, P. 123387 - 123387
Published: May 7, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29689 - 29703
Published: Oct. 14, 2024
Cold exposure (CE) therapy can quickly induce tumor starvation by brown adipose tissue (BAT) thermogenesis. Exploring the combined antitumor mechanism of CE and traditional therapies (such as radiotherapy (RT)) is exciting promising. In this study, we investigated effect in combination with nitric oxide (NO) gas on sensitizing tumors to RT promoting radio-immunotherapy. We first constructed a liposome (SL) loaded NO prodrug S-nitroso-N-acetylpenicillamine (SNAP). When SL injected, glutathione (GSH) within region promotes release from SNAP. Subsequently, superoxide anion produced reacts generate peroxynitrite (ONOO–), which has strong oxidative properties induces cell death. Meanwhile, mice were exposed environment 4 °C. CE-mediated BAT thermogenesis induced starvation, led decrease ATP GSH content well an improvement hypoxic microenvironment myeloid-derived suppressor cells. All above have promoted effectiveness activated systemic immunity. bilateral experiment, treatment primary inhibited growth distant infiltration CD8+ T cells into tumor. These findings reveal that synergy CE, therapy, could confer high effective anticancer effects, providing possibilities personalized cancer treatment.
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156383 - 156383
Published: Oct. 1, 2024
Language: Английский
Citations
0