Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101400 - 101400
Published: Dec. 12, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 2, 2025
Metal-phenolic networks (MPNs), which comprise supramolecular amorphous formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis cumulative research advancements and utilizations MPNs in nanomedicine remains absent. Thus, this review endeavors to firstly delineate characteristic polyphenols, their intricate interaction modalities MPNs. Subsequently, it elucidates merits demerits diverse methodologies employed for MPNs, alongside exploring potential functional attributes. Furthermore, consolidates applications across various nanomedical domains encompassing tumor therapy, antimicrobial interventions, medical imaging, among others. Moreover, meticulous exposition journey from ingress into human body eventual excretion is provided. Lastly, persistent challenges promising avenues pertaining are delineated. Hence, offering on current nanomedicine, consequently indirect insights clinical implementation.
Language: Английский
Citations
3
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553
Published: Feb. 5, 2025
Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Abstract Diabetic oral ulcers pose a significant challenge in healing due to persistent inflammation. Despite local therapeutic interventions remaining the primary mode of treatment, dynamic nature cavity, characterized by continuous muscular activity and salivary secretion, poses barriers sustained drug retention thereby limits efficacy. To address this issue, an approach has been devised that aims facilitate transdermal delivery bioactive components promote diabetic ulcers. A multifunctional soluble microneedle (MN) patch is prepared using γ‐polyglutamic acid (γ‐PGA), which loaded with quercetin (Qu)‐modified Mg−Zn layered hydroxide salt (LHS) nanosheets (LHSQ) anti‐inflammatory, antimicrobial pro‐angiogenic bioactivities combat These findings demonstrate LHSQ‐loaded MN (LHSQ‐MN) patches are capable effectively penetrating mucosa. In rat model ulcers, application LHSQ‐MN found establishment regeneration sites, regulate inflammatory microenvironment damaged tissues, exhibit potent antibacterial effects, expedite reconstitution mucosal epithelium, accelerate ulcer through promotion angiogenesis. outcomes highlight potential as promising strategy for management patients.
Language: Английский
Citations
2
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136321 - 136321
Published: Feb. 1, 2025
Language: Английский
Citations
1
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Metal‐phenolic networks (MPNs) integrated with functionalized cellulose nanofibers present a promising platform for stabilizing oxidation‐sensitive compounds. Here, novel antioxidant pickering emulsion system utilizing MPN‐decorated carboxyl‐functionalized pulp (MPN‐PCNF) is demonstrated. The exhibits exceptional interfacial stability through synergistic effects of MPN coating and alkyl functionalization, validated by DLVO theoretical modeling rheological characterization. MPN‐PCNF demonstrates remarkable efficacy, achieving 94% α‐tocopherol retention over 50 days 80% reduction in cellular reactive oxygen species. In reconstructed human skin models, the significantly attenuates UV‐induced oxidative stress, evidenced preserved stratum corneum integrity suppressed matrix metalloproteinase‐1 expression. This biocompatible represents versatile solution protecting compounds across pharmaceutical, cosmetic, food applications, offering sustainable alternative to conventional synthetic systems.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101642 - 101642
Published: March 7, 2025
The integration of living microbes, specifically bacteria and fungi, with metal-organic nanocoatings has led to the recent development cyborg microbe biohybrids, which show excellent adaptability functionality for a wide range potential applications in biotechnology medicine. This review discusses strategies, functionalisation, these are categorised into two types coatings: frameworks (MOFs) metal-phenolic networks (MPNs). Key advances their synthetic approaches via in-situ pre-synthesised coatings crucially addressed, yet methodology details specific advantages highlighted. Despite notable advancements, there various limitations challenges, such as determination long-term viability stability insufficient work on theranostic essentially scaling-up difficulties industrial clinical translation. latest advancements biohybrids related technology have established critical foundation enhancing innovative studies through strong interdisciplinary teamwork.
Language: Английский
Citations
1
Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1218 - 1218
Published: March 8, 2025
Metal phenolic networks (MPNs) have attracted significant attention due to their environmentally benign nature, broad compatibility, and universal adhesive properties, making them highly effective for modifying adsorbent surfaces. These supramolecular complexes are formed through the coordination of metal ions with natural ligands, resulting in stable structures while retaining active adsorption sites thereby enhancing performance unmodified substrates. Among various MPNs, ion gallic acid (GA) particularly well-known exceptional stability, biological activity, superior ability. This review offers a comprehensive examination GA-based MPN adsorbents, focusing on formation chemistry, characterization techniques, applications. The chemistry underlying stability GA–metal is analyzed equilibrium studies, which critical understanding robustness MPNs. main analytical methods assessing ligand interactions discussed, along additional techniques evaluating properties. also explores synthesis enhancement strategies including stand-alone MPN-mediated mesoporous materials, MPN-MOF composites, MPN-coated By consolidating current advancements MPN-based adsorbents offering fundamental insights into characterization, this serves as valuable resource researchers seeking develop stable, functional metal-organic materials. It aims drive innovation sustainable efficient technologies diverse environmental industrial
Language: Английский
Citations
1
Science Advances, Journal Year: 2024, Volume and Issue: 10(50)
Published: Dec. 13, 2024
Metal-organic networks have attracted widespread interest owing to their hybrid physicochemical properties. Natural biomolecules represent attractive building blocks for these materials because of inherent biological function and high biocompatibility; however, assembling them into coordination network materials, especially nanoparticles (NPs), is challenging. Herein, we exploit the between metal ions phosphonate groups, which are present in many biomolecules, form metal-biomolecule (MBN) NPs aqueous solution at room temperature. Various phosphonate-containing including plant phytate, DNA, proteins, were used assemble MBN with tunable properties (e.g., size). In addition excellent biocompatibility cargo-loading efficiency (>95%), two-component various functionalities, endosomal escape, immune regulation, molecular recognition, thus offering advantages over nonbiomolecular-based materials. This work expands our understanding metal-organic chemistry emerging class systems provides a pathway incorporating biofunctionalities advanced diverse fields.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160296 - 160296
Published: Feb. 1, 2025
Language: Английский
Citations
0