Two birds with one stone: Natural polyphenols boosted periodontitis treatment of chlorhexidine via reducing toxicity and regulating microenvironments

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Chlorhexidine (CHX) is considered the gold standard for controlling periodontal plaque and has been extensively used as a topical agent in treating periodontitis. Nevertheless, practical clinical application of CHX still constrained by inherent limitations its properties, including toxicity, inadequate biofilm scavenging capacity, single biological effect. In this study, polyphenolic epigallocatechin gallate (EGCG) employed to integrate with form an EGCG-CHX nanoplatform

Language: Английский

Integrating enzyme-nanoparticles bring new prospects for the diagnosis and treatment of immune dysregulation in periodontitis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 1, 2024

Enzymes play a significant role in mediating inflammatory and immune responses periodontitis. Effective diagnosis, timely treatment, continuous management of periodontal enzymes are essential to prevent undesirable consequences; however, this remains challenge. Nanoparticles (NPs) have attracted attention biomedicine because their advantageous nanosized effects. NPs conjugated with specific enzyme substrates at responsive sites that triggered by periodontitis biomarkers, leading functional or characteristic changes. In contrast, enzyme-mimetic activities exhibit catalytic activity, effectively destroying pathogenic biofilms modulating the response The unique properties enzyme-targeting enabled development biosensors fluorescent probes capable identifying biomarkers associated Enzyme-responsive both exert therapeutic applications treatment review, we provide comprehensive overview periodontitis, mechanisms enzyme-responsive NPs, recent advancements use for detecting these enzymes, targeting mimicking functions. We also discuss challenges prospects using diagnosis

Language: Английский

Recent advances in nanoarchitectonics of two-dimensional nanomaterials for dental biosensing and drug delivery

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 337, P. 103388 - 103388

Published: Dec. 28, 2024

Language: Английский