Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 19, 2024
The
substantial
mortality
and
morbidity
of
hepatocellular
carcinoma,
representing
90%
liver
cancers,
poses
a
significant
health
burden.
effectiveness
traditional
carcinoma
treatments
such
as
surgical
resection,
radiotherapy,
chemotherapy
is
limited,
underscoring
the
need
for
innovative
therapeutic
strategies.
To
this
end,
we
synthesized
phthalyl-pullulan
nanoparticles
encapsulating
IR780
(an
NIR-responsive
heptamethine
cyanine
dye)
R848
(resiquimod;
TLR7/8
agonist)
(PIR
NPs).
Characterization
confirmed
size
loading
capacity
PIR
NPs,
controlled
release
therefrom
upon
NIR
irradiation,
thereby
establishing
potential
versatile
tool.
NPs
were
readily
taken
up
by
Hepa
1-6
cells
in
vitro
targeting
asialoglycoprotein
receptors
present
on
its
cellular
surface.
In
vivo
experiments
combining
photothermal
therapy
immunotherapy,
following
local
near-infrared
accumulated
tumor
sites
induced
immunogenic
cell
death
activated
tumor-specific
T-cell
immune
response,
thus
highlighting
their
potent
antitumor
efficacy.
combined
efficacy
immunotherapy
presents
promising
avenue
addressing
shortcomings
interventions.
This
study
contributes
valuable
insights
into
development
more
effective
targeted
approaches
treatment.
ACS Macro Letters,
Journal Year:
2024,
Volume and Issue:
13(7), P. 834 - 840
Published: June 24, 2024
Supramolecular
coordination
complexes
(SCCs)
are
popular
for
their
structural
diversity
and
functional
adaptability,
which
make
them
suitable
a
wide
range
of
applications.
Photophysical
mechanical
performance
SCCs
the
most
attractive
characteristics,
yet
ionically
conductive
behavior
potential
in
electrical
sensing
have
been
rarely
investigated.
This
study
reports
well-designed
SCC
that
integrates
orthogonal
metal
host–guest
interactions
to
achieve
sensitive
thermal
sensing.
Owing
thermodynamic
nature
interaction,
encounters
thermally
induced
disassembly,
leading
significantly
enhanced
ion
mobility
thus
allowing
precise
detection
minor
temperature
variation.
The
SCC-based
thermometer
is
then
fabricated
with
assistance
3D
printing
demonstrates
good
accuracy
reliability
monitoring
human
skin
real-time
changes
mouse
during
whole
anesthesia
recovery
process.
Our
findings
provide
an
innovative
strategy
developing
thermometers
expand
current
application
scope
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
39(1)
Published: Sept. 26, 2024
ABSTRACT
Herein,
a
new
hybrid
inorganic–organic
ligand
was
designed
and
synthesized
to
form
series
of
transition
metal
(II)
complexes
as
potential
substrate
towards
cytotoxicity
studies.
The
inorganic
heterocycle,
cyclotriphosphazene
(N
3
P
Cl
6
,
CTP)
chosen
the
core
unit
synthesize
geminal
hydrazone
Schiff
bases
multisite
coordination
via
substitution
six
reactive
chlorine.
CTP
substituted
by
nucleophilic
reaction
at
chlorine
atoms
that
exist
on
three
phosphorus
(V)
centers
with
salicylaldehyde
hexakis
derivative.
Further,
salicylic
hydrazide
tethered
terminal
amine
group
condensed
above
derivative
ratio
1:6
afforded
SBCTP
ligand.
Indeed,
M
(M
=
Co,
Ni,
Mn,
Cu
Zn)
were
obtained
from
characteristic
functional
groups
manifest
cytotoxic
activity,
in
order
venture
active
anticancer
agent
pharmaceutics.
Despite
base
aromatic
rings
tend
exhibit
inherent
properties,
complementary
influence
appended
two
consecutive
units
found
show
unique
properties.
In
particular,
imine
bonds
oriented
ring
reveal
essential
properties
treat
cancerous
cells.
prospective
investigated
individually
for
activity
normal
cells
five
different
concentrations,
with/without
addition
samples
into
MTT
assay.
Structural
characterization
conducted
multinuclear
NMR,
1
H,
13
C,
31
well
ESI,
HRMS,
FTIR,
EDS,
TGA
data.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 19, 2024
The
substantial
mortality
and
morbidity
of
hepatocellular
carcinoma,
representing
90%
liver
cancers,
poses
a
significant
health
burden.
effectiveness
traditional
carcinoma
treatments
such
as
surgical
resection,
radiotherapy,
chemotherapy
is
limited,
underscoring
the
need
for
innovative
therapeutic
strategies.
To
this
end,
we
synthesized
phthalyl-pullulan
nanoparticles
encapsulating
IR780
(an
NIR-responsive
heptamethine
cyanine
dye)
R848
(resiquimod;
TLR7/8
agonist)
(PIR
NPs).
Characterization
confirmed
size
loading
capacity
PIR
NPs,
controlled
release
therefrom
upon
NIR
irradiation,
thereby
establishing
potential
versatile
tool.
NPs
were
readily
taken
up
by
Hepa
1-6
cells
in
vitro
targeting
asialoglycoprotein
receptors
present
on
its
cellular
surface.
In
vivo
experiments
combining
photothermal
therapy
immunotherapy,
following
local
near-infrared
accumulated
tumor
sites
induced
immunogenic
cell
death
activated
tumor-specific
T-cell
immune
response,
thus
highlighting
their
potent
antitumor
efficacy.
combined
efficacy
immunotherapy
presents
promising
avenue
addressing
shortcomings
interventions.
This
study
contributes
valuable
insights
into
development
more
effective
targeted
approaches
treatment.
