Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma DOI Creative Commons
Amal Babu,

Sathiyamoorthy Padmanaban,

Sahil Chahal

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% liver cancers, poses a significant health burden. effectiveness traditional carcinoma treatments such as surgical resection, radiotherapy, chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) R848 (resiquimod; TLR7/8 agonist) (PIR NPs). Characterization confirmed size loading capacity PIR NPs, controlled release therefrom upon NIR irradiation, thereby establishing potential versatile tool. NPs were readily taken up by Hepa 1-6 cells in vitro targeting asialoglycoprotein receptors present on its cellular surface. In vivo experiments combining photothermal therapy immunotherapy, following local near-infrared accumulated tumor sites induced immunogenic cell death activated tumor-specific T-cell immune response, thus highlighting their potent antitumor efficacy. combined efficacy immunotherapy presents promising avenue addressing shortcomings interventions. This study contributes valuable insights into development more effective targeted approaches treatment.

Language: Английский

Thermal-Sensitive Supramolecular Coordination Complex Formed by Orthogonal Metal Coordination and Host–Guest Interactions for an Electrical Thermometer DOI
Miaomiao Yan,

Yinglong Bao,

Sen Li

et al.

ACS Macro Letters, Journal Year: 2024, Volume and Issue: 13(7), P. 834 - 840

Published: June 24, 2024

Supramolecular coordination complexes (SCCs) are popular for their structural diversity and functional adaptability, which make them suitable a wide range of applications. Photophysical mechanical performance SCCs the most attractive characteristics, yet ionically conductive behavior potential in electrical sensing have been rarely investigated. This study reports well-designed SCC that integrates orthogonal metal host–guest interactions to achieve sensitive thermal sensing. Owing thermodynamic nature interaction, encounters thermally induced disassembly, leading significantly enhanced ion mobility thus allowing precise detection minor temperature variation. The SCC-based thermometer is then fabricated with assistance 3D printing demonstrates good accuracy reliability monitoring human skin real-time changes mouse during whole anesthesia recovery process. Our findings provide an innovative strategy developing thermometers expand current application scope

Language: Английский

Citations

1

Cytotoxic Studies on Hybrid Inorganic Organic Hydrazone Metal (II) Complexes: Synthesis and Characterization of Geminal Multisite Assembly on Cyclotriphosphazene DOI
Dinesh Kumar Chelike, Muhammad Sadiq,

B. Abinash

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 26, 2024

ABSTRACT Herein, a new hybrid inorganic–organic ligand was designed and synthesized to form series of transition metal (II) complexes as potential substrate towards cytotoxicity studies. The inorganic heterocycle, cyclotriphosphazene (N 3 P Cl 6 , CTP) chosen the core unit synthesize geminal hydrazone Schiff bases multisite coordination via substitution six reactive chlorine. CTP substituted by nucleophilic reaction at chlorine atoms that exist on three phosphorus (V) centers with salicylaldehyde hexakis derivative. Further, salicylic hydrazide tethered terminal amine group condensed above derivative ratio 1:6 afforded SBCTP ligand. Indeed, M (M = Co, Ni, Mn, Cu Zn) were obtained from characteristic functional groups manifest cytotoxic activity, in order venture active anticancer agent pharmaceutics. Despite base aromatic rings tend exhibit inherent properties, complementary influence appended two consecutive units found show unique properties. In particular, imine bonds oriented ring reveal essential properties treat cancerous cells. prospective investigated individually for activity normal cells five different concentrations, with/without addition samples into MTT assay. Structural characterization conducted multinuclear NMR, 1 H, 13 C, 31 well ESI, HRMS, FTIR, EDS, TGA data.

Language: Английский

Citations

1

NIR-induced antimicrobial efficacy of TPA-BOIMPY conjugate through photothermal and photodynamic synergy DOI
Worakrit Saiyasombat,

Sineenat Sripattanakul,

Sastiya Kampaengsri

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 116136 - 116136

Published: Nov. 12, 2024

Language: Английский

Citations

1

A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade DOI Creative Commons
Yujun Bao, Guanghao Li,

Siqi Li

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101346 - 101346

Published: Nov. 16, 2024

Language: Английский

Citations

1

Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma DOI Creative Commons
Amal Babu,

Sathiyamoorthy Padmanaban,

Sahil Chahal

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% liver cancers, poses a significant health burden. effectiveness traditional carcinoma treatments such as surgical resection, radiotherapy, chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) R848 (resiquimod; TLR7/8 agonist) (PIR NPs). Characterization confirmed size loading capacity PIR NPs, controlled release therefrom upon NIR irradiation, thereby establishing potential versatile tool. NPs were readily taken up by Hepa 1-6 cells in vitro targeting asialoglycoprotein receptors present on its cellular surface. In vivo experiments combining photothermal therapy immunotherapy, following local near-infrared accumulated tumor sites induced immunogenic cell death activated tumor-specific T-cell immune response, thus highlighting their potent antitumor efficacy. combined efficacy immunotherapy presents promising avenue addressing shortcomings interventions. This study contributes valuable insights into development more effective targeted approaches treatment.

Language: Английский

Citations

1