Controlling Glycan Folding with Ionic Functional Groups DOI Creative Commons

Nishu Yadav,

Ana Poveda,

Yadiel Vázquez Mena

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Glycans are intrinsically flexible molecules that can adopt many conformations. These often carry ionic functional groups influence glycan's conformational preferences, dynamics, and aggregation tendencies. Inspired by these mechanisms, we have engineered a glycan sequence whose secondary structure be precisely manipulated using groups. We strategically incorporated substituents into adopting hairpin conformation. Complementary stabilized the closed conformers, while repulsions shifted populations toward open forms. External stimuli, such as pH variations or enzyme addition, enabled us to dynamically control hairpin's opening closing. Additionally, changes in protonation states led aggregation, suggesting opportunities for creation of responsive glycan-based materials.

Language: Английский

Smart polymers advance analytical chemistry DOI
Yahui Zhang, Xinjia Zhao, Guangyan Qing

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118198 - 118198

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanomechanical investigation of deformation behavior of π–π stacked helical polymers DOI

Yuri Jeon,

Byeonghwa Goh, Joonmyung Choi

et al.

International Journal of Mechanical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 110100 - 110100

Published: Feb. 1, 2025

Language: Английский

Citations

0
Continuous Porous Aromatic Framework Membrane with Acid/Base-induced Reversible Isomerization for Switchable Ion Conductivity DOI Creative Commons
Jian Song,

Hengtao Lei,

Lin Lin

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Continuous porous aromatic framework membranes were designed and constructed to achieve the first example of ion conductive frameworks continuous that dynamically respond chemical acid/base stimulus.

Language: Английский

Citations

0
Helical Sense Control of Metal–Peptide Torus Frameworks Leading to the Folding and Assembly of a Ag21L14 Braided Peptide Nanotube DOI Creative Commons

Sota Oguma,

Yuuki Inomata,

Akihiro Hayakawa

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

The chirality of helical polypeptides is correlated to that their constituent amino acid residues. For with non-natural backbones, however, such correlations are less clear. Here, circular double helices torus knot/link topologies were assembled from metal-peptide chains composed Ag(I) ions and ditopic tripeptides Gly-Gly-Ala Gly-Ala-Gly sequences. We found the structures determined by l-Ala's dihedral angles. A tubular dimeric structure an M21L14 composition was further achieved via additional metal cross-linking, showing rational design potential for artificial peptide helices.

Language: Английский

Citations

0
Controlling Glycan Folding with Ionic Functional Groups DOI Creative Commons

Nishu Yadav,

Ana Poveda,

Yadiel Vázquez Mena

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Glycans are intrinsically flexible molecules that can adopt many conformations. These often carry ionic functional groups influence glycan's conformational preferences, dynamics, and aggregation tendencies. Inspired by these mechanisms, we have engineered a glycan sequence whose secondary structure be precisely manipulated using groups. We strategically incorporated substituents into adopting hairpin conformation. Complementary stabilized the closed conformers, while repulsions shifted populations toward open forms. External stimuli, such as pH variations or enzyme addition, enabled us to dynamically control hairpin's opening closing. Additionally, changes in protonation states led aggregation, suggesting opportunities for creation of responsive glycan-based materials.

Language: Английский

Citations

0