ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Since
the
1980s,
surface
enhanced
Raman
scattering
(SERS)
has
been
used
for
rapid
and
sensitive
detection
of
biomolecules.
Whether
a
label-free
or
labeled
assay
is
adopted,
SERS
demonstrated
low
limits
in
variety
biological
matrices.
However,
analysis
confined
to
laboratory
due
several
reasons
such
as
reproducibility
scalability,
both
which
have
discussed
at
length
literature.
Another
possible
issue
with
lack
widespread
adoption
that
its
application
point
use
(POU)
testing
only
now
being
fully
explored
advent
portable
spectrometers.
Researchers
are
investigating
how
can
be
output
on
POU
platforms
lateral
flow
assays,
wearable
sensors,
volatile
organic
compound
(VOC)
human
healthcare
monitoring,
favorable
results
rival
gold
standard
approaches.
obstacle
faces
interpretation
wealth
information
obtained
from
platform.
To
combat
this,
machine
learning
shown
provide
quick
accurate
generated
data,
leading
discrimination
many
clinically
relevant
This
review
will
discuss
advancements
combined
strength
bring
produce
powerful
platform
monitoring.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
This
review
comprehensively
presents
the
fifty-year
journey
of
surface-enhanced
Raman
spectroscopy
(SERS),
covering
its
discovery,
pivotal
phases,
innovative
methods,
and
key
inspirations
from
pioneers
trailblazers.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Functional
nucleic
acids
constitute
a
distinct
category
of
that
diverge
from
conventional
acid
amplification
methodologies.
They
are
capable
forming
intricate
hybrid
structures
through
Hoogsteen
and
reverse
hydrogen
bonding
interactions
between
double-stranded
single-stranded
DNA,
thereby
broadening
the
spectrum
DNA
interactions.
In
recent
years,
functional
DNA/RNA-based
surface-enhanced
Raman
spectroscopy
(SERS)
has
emerged
as
potent
platform
ultrasensitive
multiplexed
detection
variety
analytes
interest.
This
review
aims
to
elucidate
operational
principles
several
in
SERS
detection,
including
DNAzymes,
G-quadruplexes,
aptamers,
CRISPR,
origami
etc.,
alongside
design
methodologies
practical
applications
sensing.
Initially,
an
overview
is
summarized
encompassing
structural
attributes
sensing
mechanisms
inherent
diverse
DNA/RNA.
Following
this,
various
innovative
strategies
for
constructing
acid-based
sensors
illustrated
detail,
aimed
at
improving
present
capabilities.
A
comprehensive
summing
up
then
conducted
on
these
crucial
fields,
such
disease
diagnosis,
environmental
monitoring,
food
safety
with
particular
focus
sensitivity,
specificity,
analytical
versatility.
Finally,
conclusive
remarks
offered
along
exploration
existing
challenges
prospective
avenues
future
research
this
developed
field.
Biosensors and Bioelectronics,
Journal Year:
2024,
Volume and Issue:
263, P. 116632 - 116632
Published: Aug. 3, 2024
Microfluidic
devices
are
increasingly
widespread
in
the
literature,
being
applied
to
numerous
exciting
applications,
from
chemical
research
Point-of-Care
devices,
passing
through
drug
development
and
clinical
scenarios.
Setting
up
these
microenvironments,
however,
introduces
necessity
of
locally
controlling
variables
involved
phenomena
under
investigation.
For
this
reason,
literature
has
deeply
explored
possibility
introducing
sensing
elements
investigate
physical
quantities
biochemical
concentration
inside
microfluidic
devices.
Biosensors,
particularly,
well
known
for
their
high
accuracy,
selectivity,
responsiveness.
However,
signals
could
be
challenging
interpret
must
carefully
analysed
carry
out
correct
information.
In
addition,
proper
data
analysis
been
demonstrated
even
increase
biosensors'
mentioned
qualities.
To
regard,
machine
learning
algorithms
undoubtedly
among
most
suitable
approaches
undertake
job,
automatically
highlighting
biosensor
signals'
characteristics
at
best.
Interestingly,
it
was
also
benefit
themselves,
a
new
paradigm
that
is
starting
name
"intelligent
microfluidics",
ideally
closing
benefic
interaction
disciplines.
This
review
aims
demonstrate
advantages
triad
microfluidics-biosensors-machine
learning,
which
still
little
used
but
great
perspective.
After
briefly
describing
single
entities,
different
sections
will
benefits
dual
interactions,
applications
where
reviewed
employed.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
article
provides
a
comprehensive
overview
of
recent
advances
in
the
development
bioorthogonally
activated
probes
for
labelling
and
precise
situ
fluorescence
imaging
both
vitro
vivo
.
