Recent advancements in the applications of separation and enrichment strategies towards SERS detection

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 184, P. 118136 - 118136

Published: Jan. 7, 2025

Language: Английский

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Advances in Functional Nucleic Acid SERS Sensing Strategies

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Functional nucleic acids constitute a distinct category of that diverge from conventional acid amplification methodologies. They are capable forming intricate hybrid structures through Hoogsteen and reverse hydrogen bonding interactions between double-stranded single-stranded DNA, thereby broadening the spectrum DNA interactions. In recent years, functional DNA/RNA-based surface-enhanced Raman spectroscopy (SERS) has emerged as potent platform ultrasensitive multiplexed detection variety analytes interest. This review aims to elucidate operational principles several in SERS detection, including DNAzymes, G-quadruplexes, aptamers, CRISPR, origami etc., alongside design methodologies practical applications sensing. Initially, an overview is summarized encompassing structural attributes sensing mechanisms inherent diverse DNA/RNA. Following this, various innovative strategies for constructing acid-based sensors illustrated detail, aimed at improving present capabilities. A comprehensive summing up then conducted on these crucial fields, such disease diagnosis, environmental monitoring, food safety with particular focus sensitivity, specificity, analytical versatility. Finally, conclusive remarks offered along exploration existing challenges prospective avenues future research this developed field.

Language: Английский

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Surface-enhanced Raman spectroscopy: a half-century historical perspective

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review comprehensively presents the fifty-year journey of surface-enhanced Raman spectroscopy (SERS), covering its discovery, pivotal phases, innovative methods, and key inspirations from pioneers trailblazers.

Language: Английский

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Integrating machine learning and biosensors in microfluidic devices: A review

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 263, P. 116632 - 116632

Published: Aug. 3, 2024

Microfluidic devices are increasingly widespread in the literature, being applied to numerous exciting applications, from chemical research Point-of-Care devices, passing through drug development and clinical scenarios. Setting up these microenvironments, however, introduces necessity of locally controlling variables involved phenomena under investigation. For this reason, literature has deeply explored possibility introducing sensing elements investigate physical quantities biochemical concentration inside microfluidic devices. Biosensors, particularly, well known for their high accuracy, selectivity, responsiveness. However, signals could be challenging interpret must carefully analysed carry out correct information. In addition, proper data analysis been demonstrated even increase biosensors' mentioned qualities. To regard, machine learning algorithms undoubtedly among most suitable approaches undertake job, automatically highlighting biosensor signals' characteristics at best. Interestingly, it was also benefit themselves, a new paradigm that is starting name "intelligent microfluidics", ideally closing benefic interaction disciplines. This review aims demonstrate advantages triad microfluidics-biosensors-machine learning, which still little used but great perspective. After briefly describing single entities, different sections will benefits dual interactions, applications where reviewed employed.

Language: Английский

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Surface-Enhanced Raman Scattering Nanosensing and Imaging in Neuroscience

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 22620 - 22647

Published: Aug. 1, 2024

Monitoring neurochemicals and imaging the molecular content of brain tissues

Language: Английский

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Advances in SERS detection method combined with microfluidic technology for bio-analytical applications

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 125797 - 125797

Published: Jan. 1, 2025

Language: Английский

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Colorimetric/SERS dual-mode detection for chloramphenicol through MIL-101/Au ETHH NR based catalysis and structural degradation

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106032 - 106032

Published: Jan. 1, 2025

Language: Английский

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Rapid and Sensitive Escherichia coli Detection: Integration of SERS and Acoustofluidics in a Lysis-Free Microfluidic Platform

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Bacterial infections, such as sepsis, require prompt and precise identification of the causative bacteria for appropriate antibiotics treatment. Traditional methods culturing take 2-5 days, while newer techniques reverse transcription-polymerase chain reaction mass spectrometry are hindered by blood impurities. Consequently, this study developed a surface-enhanced Raman scattering (SERS)-based acoustofluidic technique rapid bacterial detection without or lysing. Target first tagged with SERS nanotags in microtube. The solution unbound is passed through silicon microfluidic channel. A piezoelectric transducer generates acoustic waves within channel, concentrating larger center pushing smaller toward channel walls. laser beam focused at signals passing focal volume measured quantitative analysis. As proof concept, detected various concentrations Escherichia coli limit 1.75 × 105 CFU/mL 1 h. This method offers significant clinical potential, enabling accurate genetic material extraction, cultivation, lysis.

Language: Английский

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Advancing SERS Applications of 2D Materials through the Interplay of Rational Design and Structure‐Property Relationships

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical tool for molecular investigations, particularly in biological systems. While metal nanoparticles (NPs) have been widely explored SERS, their performance depends on size, shape, and crystal structure. However, scattering efficiency low, limiting applications. To overcome these challenges, 2D materials emerged as promising SERS substrates due to high surface area, charge transfer capabilities, stability, tunable optical properties. Their biocompatibility makes them ideal chemical biomedical applications, including microfluidic systems, drug delivery, vivo diagnostics. This review comprehensively examines the development, structural characteristics, plasmonic integration of SERS. It highlights design considerations, optimization using machine learning (ML), material performance. ML-driven approaches enable precise tuning materials' optical, electrical, properties, enhancing biosensing capabilities. Computational algorithms facilitate detection ultra-low concentrations biomolecules such deoxyribonucleic acid (DNA), proteins, metabolites. ML also offers powerful tools data analysis, optimization, automated sensing, significantly advancing The synergy between opens new avenues high-performance technologies.

Language: Английский

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Bioorthogonally activated probes for precise fluorescence imaging

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This article provides a comprehensive overview of recent advances in the development bioorthogonally activated probes for labelling and precise situ fluorescence imaging both vitro vivo .

Language: Английский

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