Redefining Metal Organic Frameworks in Biosensors: Where Are We Now? DOI

Melisa Wei Ning Leoi,

Xin Ting Zheng, Yong Yu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13246 - 13278

Published: Feb. 21, 2025

As a broad class of porous nanomaterials, metal organic frameworks (MOFs) exhibit unique properties, such as tunability, high stability, atomically well-defined structure, and ordered uniform porosity. These features facilitate the rational design MOFs an outstanding nanomaterial candidate in biosensing, therapeutics delivery, catalysis applications. Recently, novel modifications MOF nanoarchitecture incorporation synergistic guest materials have been investigated to achieve well-tailored functional design, gradually bridging fundamental gap between structure targeted activity. Specifically, burgeoning studies MOF-based high-performance biosensors aimed sensitivity, selectivity, stability for large variety analytes different sensing matrices. In this review, we elaborate key roles nanomaterials biosensors, including their protective framework biomolecules, intrinsic sensitivity-enhancing functionalities, contribution catalytic activity nanozyme. By examining main structures MOFs, further identify varied structural engineering approaches, precursor tuning molecule incorporation, that elucidate concept structure-activity relationship MOFs. Furthermore, highlight applications electrochemical optical enhanced sensor performances. Finally, challenges future perspectives developing next-generation biosensor are discussed.

Language: Английский

Redefining Metal Organic Frameworks in Biosensors: Where Are We Now? DOI

Melisa Wei Ning Leoi,

Xin Ting Zheng, Yong Yu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13246 - 13278

Published: Feb. 21, 2025

As a broad class of porous nanomaterials, metal organic frameworks (MOFs) exhibit unique properties, such as tunability, high stability, atomically well-defined structure, and ordered uniform porosity. These features facilitate the rational design MOFs an outstanding nanomaterial candidate in biosensing, therapeutics delivery, catalysis applications. Recently, novel modifications MOF nanoarchitecture incorporation synergistic guest materials have been investigated to achieve well-tailored functional design, gradually bridging fundamental gap between structure targeted activity. Specifically, burgeoning studies MOF-based high-performance biosensors aimed sensitivity, selectivity, stability for large variety analytes different sensing matrices. In this review, we elaborate key roles nanomaterials biosensors, including their protective framework biomolecules, intrinsic sensitivity-enhancing functionalities, contribution catalytic activity nanozyme. By examining main structures MOFs, further identify varied structural engineering approaches, precursor tuning molecule incorporation, that elucidate concept structure-activity relationship MOFs. Furthermore, highlight applications electrochemical optical enhanced sensor performances. Finally, challenges future perspectives developing next-generation biosensor are discussed.

Language: Английский

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