Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

The creation of fluorescent nanoprobes capable both detecting and neutralizing reactive oxygen species (ROS) has remained an elusive goal in biomedical research. In this study, we present a straightforward one-pot solvothermal approach to synthesize elemental selenium quantum dots (SeQDs), novel class metal-free nanomaterials, directly from bulk using selenium-ethylenediamine precursor. When optimized at 180 °C for 4.5 h, the SeQDs achieve impressive product yield 7.1 ± 0.5% single-photon photoluminescence (PLQY) 21.4 1.3%, along with strong two-photon fluorescence. Notably, these serve as dual-responsive hydroxyl radicals (·OH). They enable selective detection low limit 330 nM linear range 5-100 μM, while simultaneously exhibiting efficient ·OH scavenging capabilities. mechanism underlying fluorescence sensing by is likely attributed chemical reaction between ·OH. Moreover, their cytotoxicity effective cellular uptake make them highly suitable single- imaging well real-time monitoring intracellular This work not only introduces scalable strategy synthesizing but also highlights unique dual functionality combating oxidative stress, presenting promising platform investigating managing damage living systems.

Language: Английский