Neuroscience, Journal Year: 2024, Volume and Issue: 566, P. 9 - 16
Published: Dec. 19, 2024
Language: Английский
Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 1, 2024
Adiponectin, an adipose-derived hormone, plays a pivotal role in glucose regulation and lipid metabolism, with decrease circulating adiponectin levels being linked to insulin resistance prediabetes. This review examines the therapeutic potential of managing prediabetes, elucidating on multiple aspects including its influence sensitivity, anti-inflammatory properties. Moreover, paper highlights latest strategies augment levels, such as gene therapy, pharmacological interventions, dietary modifications, lifestyle changes. It also addresses challenges encountered translating preclinical findings into clinical practice, primarily related drug delivery, safety, efficacy. Lastly, proposes future directions, underlining need for large-scale human trials, novel analogs, personalized treatment harness adiponectin’s full preventing transition from prediabetes diabetes.
Language: Английский
Citations
13
Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1312 - 1312
Published: Oct. 28, 2024
Wine phenolic compounds, often known as polyphenols, are a diverse group of secondary bioactive compounds derived from grapes. They play crucial role in defining the sensory characteristics, functionality, and health benefits wine. This review explores complex chemistry these focusing on key classes such flavonoids, which include flavanones, flavonols, anthocyanins, flavan-3-ols, non-flavonoids, hydroxycinnamic acids, hydroxybenzoic stilbenes. The wine phenolics, particularly their antioxidant anti-inflammatory properties, also discussed relation to preventing reducing risk non-communicable diseases (NCDs) cardiovascular diseases, cancers, neurodegenerative conditions. Furthermore, this summarized most current data human population-based research that investigated bioactivity red phytochemicals with relevant for NCDs. Finally, proposes some perspectives future better understand bioavailability, metabolism, long-term effects compounds.
Language: Английский
Citations
7
Wine Business Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
This study aims to determine the attitudes of primary care physicians in Spain towards consumption wine and its effects on health. To this end, 199 surveys were conducted Spain. The concludes that medical professionals associate moderate drinking with possible cardiovascular benefits, although there are three groups different toward relationship All groups, however, coincide view amount consumed must be limited. paper makes an important contribution research knowledge as it focuses perceptions wine-health among particular.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 699 - 699
Published: Feb. 15, 2025
Background: Our recent findings, of the highest survival rate animals that consumed moderate amounts white wine for four weeks prior to surgically induced myocardial infarction by ligation left anterior descending artery, prompted us investigate inflammatory aspects post-infarction healing process. In order examine whether effects consumption differ from ethanol, experimental were randomized into three groups: wine, 13% v/v ethanol/water or water-only controls. Methods: Hearts immunohistochemical analysis collected survived 96 h after infarction, no less than 8 mL solution per day and had transmural infarcts comparable sizes. After accounting all above criteria, final number was seven group. Tissue slices stained with a pan-macrophage marker CD68 an anti-inflammatory macrophage CD163 polarization is crucial healing. Immunofluorescent imaging performed on zones surrounding infarcted area detritus: subepicardial, subendocardial two peri-infarct zones. Results: The largest CD163/CD68 ratios volumes alcohol observed in group decreased both ethanol as average amount alcoholic beverage increased. Conclusions: results indicate non-alcoholic constituents contribute its superior favorable modulation inflammation processes relative alone.
Language: Английский
Citations
0
Food Bioengineering, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
ABSTRACT Xinhui Chenpi , a China National Geographical Indication Product, faces unexploited pulp resources, resulting in resource waste and potential environmental pollution. This study employed citrus as raw material to produce wine (XCW), focusing on enhancing the aroma of XCW by utilizing multi‐strains fermentation involving Saccharomyces cerevisiae Lachancea thermotolerans . The effect S. Red and/or L. L19 enological parameters, physicochemical characteristics volatile compounds XCWs were evaluated. mixed strains demonstrated significant increase esters content, including 2,3‐butanediol dinitrate, diethyl succinate, ethyl benzoate, lactate, glycolate compared those mono ( p < 0.05), thereby fruity floral aromas XCW. key relative odor activity value (rOAV) > 1, which are specific fermentation, 2‐methylbutyrate, isovalerate, propionate, 1‐penten‐3‐ol, phenylethyl alcohol. These could strengthen fruity, flowery, sweet scents findings align with sensory evaluations, suggesting that might resolve pulp.
Language: Английский
Citations
0
International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(8), P. 1050 - 1050
Published: Aug. 9, 2024
Olive mill wastewater (OMWW), with its high level of phenolic compounds, simultaneously represents a serious environmental challenge and great resource potential nutraceutical activities. To increase the knowledge OMWW's biological effects, an aim to developing food supplement, we performed chemical characterisation extract using Liquid Chromatography-Quadrupole Time-of-flight spectrometry (LC-QTOF) in vitro genotoxicity/antigenotoxicity assessment on HepaRG ™ cells. Chemical analysis revealed that most abundant compound was hydroxytyrosol. Biological tests showed not cytotoxic at lowest tested concentrations (from 0.25 2.5 mg/mL), unlike highest 5 20 mg/mL). Regarding genotoxic activity, when non-cytotoxic concentrations, did display any effect. Additionally, OMWW antigenotoxic activity (J-shaped dose-response effect) against known mutagenic substance, reducing extent DNA damage co-exposure treatment. The effect also obtained post-exposure procedure, although only 0.015625 0.03125 mg/mL. This behaviour confirmed pre-exposure protocol. In conclusion, present study established maximum non-toxic dose for cell model, smoothing path future research.
Language: Английский
Citations
3
Food Research International, Journal Year: 2023, Volume and Issue: 178, P. 113923 - 113923
Published: Dec. 23, 2023
Language: Английский
Citations
7
Polskie Archiwum Medycyny Wewnętrznej, Journal Year: 2024, Volume and Issue: unknown
Published: March 20, 2024
It is estimated that one third of the world's population consumes alcohol.At same time, it well-known excessive alcohol consumption in leading causes premature mortality.The history production alcoholic beverages, especially wine, date as long 8000 years ago.However, humans soon realized adverse effects abuse and tried to limit its consumption.Higher associated with health loss increased risk all-cause mortality.It linearly a higher many types cancers, liver disease, incidence atrial fibrillation, hemorrhagic stroke, heart failure.Although, scientific societies recommend reduction intake specify recommended permissible amount consumed, there no proven safe for general population.There conflicting data on effect low moderate mortality most studies indicating J-shaped curve related mostly coronary artery disease complications, including cardiovascular death.Among different alcohol, red wine may have effects, due abundance antioxidative polyphenols.Wine, together plant foods, olive oil fish an important part Mediterranean diet.There are both observational randomized documenting wide spectrum health-promoting such diet, major events.People who want drink should be advised their minimum consider choosing wine.
Language: Английский
Citations
2
Medicine, Journal Year: 2024, Volume and Issue: 103(23), P. e38229 - e38229
Published: June 7, 2024
Moderate red wine (RW) consumption is associated with a low risk of cardiovascular disease (CVD). However, few studies have evaluated the effects RW and white (WW) on inflammatory markers related to atherosclerosis in healthy individuals high-risk subjects for CVD. This study aimed assess effect CVD compared moderate alcohol consumption.
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3431 - 3431
Published: Oct. 10, 2024
Background: The aging population is associated with a net increase in the incidence and prevalence of chronic-degenerative diseases, particularly neurocognitive disorders. Therefore, identification preventative strategies to restrain burden such chronic conditions key relevance. Red wine its components have accumulated evidence regarding their positive effects terms neurological pathologies symptoms. Methods: Based on this background, present narrative review aims summarize state-of-the-art red disorders both preclinical clinical settings. Results: main findings highlight protective effect polyphenols dementia different models cognitive decline. current translational remains uncertain, especially considering risk-to-benefit ratio alcohol consumption brain health. Conclusions: Given overall health risks consistent prevailing guidelines literature, there insufficient support light-to-moderate as an effective strategy for preventing these diseases. However, largely derived from remain significant interest context.
Language: Английский
Citations
2