Ghrelin alleviates inflammation and pyroptosis by inhibiting TNF-α /caspase-8/caspase-3/ GSDME signalling pathways in an in vitro model of high glucose induced liver injury DOI
Jingwen Gao, Xinrui Wang,

Shengying Ye

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102672 - 102672

Published: Dec. 10, 2024

Language: Английский

Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects DOI Creative Commons
Abdul Bari Shah, Aizhamal Baiseitova, Muhammad Zahoor

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 24, 2024

A rising corpus of research has shown the beneficial effects probiotic

Language: Английский

Citations

19
Lactiplantibacillus plantarum A5 alleviates high-fat diet-induced hyperlipidemia via regulating gut microbiota to promote short-chain fatty acids production DOI

Yanchao Lu,

Wenlong Sun,

Zeng Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105848 - 105848

Published: Jan. 1, 2025

Language: Английский

Citations

2
An emerging strategy: probiotics enhance the effectiveness of tumor immunotherapy via mediating the gut microbiome DOI Creative Commons
Shuaiming Jiang,

Wenyao Ma,

Chenchen Ma

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 8, 2024

The occurrence and progression of tumors are often accompanied by disruptions in the gut microbiota. Inversely, impact microbiota on initiation cancer is becoming increasingly evident, influencing tumor microenvironment (TME) for both local distant tumors. Moreover, it even suggested to play a significant role process immunotherapy, contributing high specificity therapeutic outcomes long-term effectiveness across various types. Probiotics, with their generally positive influence microbiota, may serve as effective agents synergizing immunotherapy. They crucial activating immune system inhibit growth. In summary, this comprehensive review aims provide valuable insights into dynamic interactions between probiotics, cancer. Furthermore, we highlight recent advances mechanisms using probiotics improve By understanding these complex relationships, unlock innovative approaches diagnosis treatment while optimizing effects

Language: Английский

Citations

10
Vinegar-processed Schisandra chinensis polysaccharide ameliorates type 2 diabetes via modulation serum metabolic profiles, gut microbiota, and fecal SCFAs DOI

Xingyu Guo,

Yang Su,

Yongqiang Du

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139514 - 139514

Published: Jan. 5, 2025

Language: Английский

Citations

0
Atractyloside-A ameliorates spleen deficiency diarrhea in mice by modulating Lactobacillus johnsonii to enhance butyrate production, activating GPR43, and inhibiting the assembly of NLRP3 DOI Creative Commons

Yangxin Xiao,

Chang Ke,

Dongpeng Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Background Spleen-deficiency diarrhea (SDD) is recognized in Traditional Chinese Medicine (TCM) as a prevalent gastrointestinal ailment, primarily characterized by chronic and persistent diarrhea, akin to classifications Western medicine. The disruption of the intestinal barrier appearance inflammation are direct causes occurrence SDD. Therefore, restoring integrity reducing an important strategy for relieving Atractyloside-A (AA), major bioactive compound derived from post-processing Atractylodes lancea (Thunb.) DC., crucial component that enhances spleen-strengthening effects following processing this herb. Previous studies have indicated AA effective treating SDD through modulation gut microbiota; however, specific molecular mechanisms underlying effect remain unclear. This study aimed elucidate pathways which exerts its therapeutic on Results showed significantly increased abundance Lactobacillus johnsonii, promoted butyrate production, enhanced GPR43 expression, modulated TLR4/NF-κB signaling pathway. inhibited assembly NLRP3 inflammasome, alleviated inflammation, reversed mucin synthesis damage, reduced pathological symptoms associated with Moreover, administration NaB, SCFAs individually resulted significant improvements various SDD-related phenotypes. However, beneficial NaB were abolished AAV-shGPR43. Conclusion production regulating activates GPR43, inhibits inflammasome pathway, thereby ameliorating mice.

Language: Английский

Citations

0
Selenium-Enriched Lactiplantibacillus plantarum ZZU 8–12 Regulates Intestinal Microbiota and Inhibits Acute Liver Injury DOI
Yanping Wang,

Hengyu Ma,

Haolong Li

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

0
Probiotics and Prebiotics: Meeting Dietary Requirements for Optimal Health and Planetary Sustainability DOI
Juan Chen, Yifei Yu,

Siyuan Sun

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Arecoline Alleviates T2DM via Gut Microbiota Modulation and Liver Gene Regulation in Mice DOI Open Access
Meng Xu,

Wanggao Li,

Yuan Xu

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Scope Arecoline, the main alkaloid in areca nut, has shown potential modulating metabolism and gut microbiota. This study aimed to evaluate its therapeutic effects on glucose lipid metabolism, inflammation, liver function, mechanisms a Type 2 diabetes mellitus (T2DM) mouse model. Methods results T2DM was established mice with high‐fat, high‐sugar diet, streptozotocin injections. Arecoline significantly reduced fasting blood glucose, enhanced tolerance, increased insulin sensitivity. Serum profiles showed marked decreases total cholesterol, triglycerides, LDL‐C levels. Systemic as measured by serum levels of IL‐1β, IL‐6, MCP‐1, decreased significantly. Improvements function were observed, indicated reductions ALT AST Liver transcriptomic analysis revealed modulation pathways related glutathione MAPK signaling, cAMP which involved signaling oxidative stress response. Additionally, arecoline mitigated dysbiosis restoring microbial diversity, altering microbiota composition, regulating key NAD biosynthesis fatty acid β‐oxidation, critical for maintaining energy homeostasis. Conclusion improves profiles, while metabolic pathways, showing agent T2DM.

Language: Английский

Citations

0
Probiotics: A potential strategy for improving diabetes mellitus complicated with cognitive impairment DOI
Xin Shen, Feiyan Zhao,

Zhixin Zhao

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 290, P. 127960 - 127960

Published: Nov. 1, 2024

Language: Английский

Citations

3
Gut microbiota and metabolite interface-mediated hepatic inflammation DOI Open Access
Ming Yang,

Katina Massad,

Eric T. Kimchi

et al.

Immunometabolism, Journal Year: 2024, Volume and Issue: 6(1), P. e00037 - e00037

Published: Jan. 1, 2024

Immunologic and metabolic signals regulated by gut microbiota relevant metabolites mediate bidirectional interaction between the liver. Gut dysbiosis, due to diet, lifestyle, bile acids, genetic environmental factors, can advance progression of chronic liver disease. Commensal bacteria have both pro- anti-inflammatory effects depending on their species relative abundance in intestine. Components derived from microbiota–diet regulate hepatic innate adaptive immune cells, as well parenchymal significantly impacting inflammation. In this mini review, recent findings specific bacterial with functions regulating inflammation are first reviewed. addition, socioeconomic hormones, genetics that shape profile microbial components function priming or dampening discussed. Finally, current clinical trials evaluating factors manipulate treat disease Overall, discussion mediators contributing will help direct our future studies

Language: Английский

Citations

2