Foods, Journal Year: 2023, Volume and Issue: 12(24), P. 4401 - 4401
Published: Dec. 7, 2023
In recent years, more plant-based sources of functional foods have been shown to be effective in preventing, reducing, and treating chronic inflammatory metabolic diseases, promoting health [...].
Language: Английский
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 11, 2024
High sugar, high-fat diets and unhealthy lifestyles have led to an epidemic of obesity obesity-related metabolic diseases, seriously placing a huge burden on socio-economic development. A deeper understanding elucidation the specific molecular biological mechanisms underlying onset development has become key treatment diseases. Recent studies shown that changes bile acid composition are closely linked Bile acids can not only emulsify lipids in intestine promote lipid absorption, but also act as signaling molecules play indispensable role regulating homeostasis, energy expenditure, glucose metabolism, immunity. Disorders metabolism therefore important risk factors for The farnesol X receptor, member nuclear receptor family, is abundantly expressed liver intestinal tissues. endogenous ligands erroneous FXR triggered by dysregulation contributes including obesity, non-alcoholic fatty disease diabetes. Activation reduce lipogenesis inhibit gluconeogenesis alleviate It been found regulate hepatic organ-wide manner. crosstalk between provides new idea This review focuses relationship diseases current research progress provide theoretical basis further clinical applications.
Language: Английский
Citations
8
Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5760 - 5760
Published: Dec. 5, 2024
Currently, natural bioactive ingredients and/or raw materials are of significant interest to scientists around the world. Flavonoids and other polyphenols a major group phytochemicals that have been researched noted as molecules. They offer several pharmacological medical benefits. This current review aims (1) illustrate their benefits for human health, such antioxidant, anti-aging, anti-cancer, anti-inflammatory, anti-microbial, cardioprotective, neuroprotective, UV-protective effects, also (2) perform quality evaluation traditional medicines future application. Consequently, keywords were searched on Scopus, Google Scholar, PubMed so search related publications. Then, those publications carefully checked in order find non-redundant studies matched objective this review. According review, researchers worldwide very interested discovering potential flavonoids polyphenols, used taken from medicinal plants, relation pharmaceutical applications. Many focus health tested using silico, vitro, vivo models. However, few carried out clinical trials trustworthy subject sizes accordance with practice guidelines. Additionally, interesting research directions perspectives highlighted work.
Language: Английский
Citations
5
Food Research International, Journal Year: 2024, Volume and Issue: 196, P. 115094 - 115094
Published: Sept. 20, 2024
Language: Английский
Citations
4
Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4283 - 4283
Published: April 13, 2025
The production of functional bread has been great interest lately to the Food Industry. Regarding this, enrichment with natural raw materials rich in phenolic antioxidants, such as fruits, become a new trend. Likewise, aim current study was evaluate novel supplements based on freeze-dried Cornelian cherry juice, both unfermented and fermented by probiotic L. plantarum ATCC 14917, sourdough production. outcome showed that supplement led elevated nutritional features terms its total content (99.5 mg GAE/100 g) antioxidant activity (213 TE/100 g for ABTS 4.7 μmol TE/g DPPH), well reduction phytic acid (93.3%) compared all other samples. In addition, same sample contained higher amounts lactic (2.91 g/Kg bread) acetic (1.23 g/Kg), formic (0.11 n-valeric (0.12 g/Kg) caproic (0.05 acids samples, leading preservation time (13 days) regarding rope mold spoilage. All breads exhibited sensorial characteristics, proving did not affect quality. This is very interesting since powdered have recently endorsed industry enabling technological improvements.
Language: Английский
Citations
0
Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112574 - 112574
Published: May 1, 2025
Language: Английский
Citations
0
Biology, Journal Year: 2024, Volume and Issue: 13(1), P. 63 - 63
Published: Jan. 22, 2024
Innate immune receptor TLR4 plays an important role in glycolipid metabolism. The objective of this study is to investigate the inhibitory effects blocking on hyperglycemia and hyperlipidemia by comparing WT TLR4−/− mice obesity diabetes modeling. knockout gene could prevent weight gain induced a high-fat diet (HFD)/high-sugar (HSHFD), differences responses existed between sexes. It extends time required reach criteria. However, when were injected with intraperitoneal streptozotocin (STZ) after being fed HSHFD for two months, exhibited less loss than WT. Blocking alleviated changes body blood glucose, consequently reducing efficiency modeling, especially male mice. Additionally, obese exhibit lower total cholesterol (TC) low-density lipoprotein (LDL) levels serum formation fat droplets liver compared On other hand, significantly increased high-density (HDL) This should provide new insights into TLR4, as well opportunities target novel approaches prevention treatment metabolic diseases like diabetes.
Language: Английский
Citations
3
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: March 21, 2024
Metabolic syndrome (MetS) is a clinical condition associated with multiple metabolic risk factors leading to type 2 diabetes mellitus and other diseases. Recent evidence suggests that modulating adipose tissue adaptive thermogenesis may offer therapeutic potential for MetS. Xiasangju (XSJ) marketed drug dietary supplement used the treatment of disease anti-inflammatory activity. This study investigated effects XSJ underlying mechanisms affecting activation brown (BAT) in The results revealed ameliorated MetS by enhancing glucose lipid metabolism, reduced body weight abdominal circumference, decreased liver index, improved blood tolerance. administration stimulated catecholamine biosynthesis, increasing noradrenaline (NA) levels activating NA-mediated proteins BAT. Thus, BAT enhanced oxidative phosphorylation (OXPHOS). Moreover, induced changes gut microbiota composition, an increase Oscillibacter abundance decrease Bilophila, Candidatus Stoquefichus, Holdemania, Parasutterella Rothia. upregulated intestinal tight junctions corresponding lower serum lipopolysaccharide (LPS), tumor necrosis factor α (TNF-α) monocyte chemoattractant protein-1 (MCP-1) interleukin-6 (IL-6) maintain NA signaling transport. In summary, alleviate promoting ultimately boost energy metabolism through strengthening barrier integrity reducing low-grade inflammation. These findings suggest has as natural agent
Language: Английский
Citations
3
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8071 - 8087
Published: July 26, 2024
, known as black chokeberry, is rich in polyphenols, comprising flavonoids, such anthocyanins, flavanols, and flavonols, phenolic acids, chlorogenic acid. These polyphenols endow
Language: Английский
Citations
3
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106783 - 106783
Published: May 1, 2025
Language: Английский
Citations
0
Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(12), P. 7182 - 7193
Published: April 16, 2024
Grape peels, the main by-products of wine processing, are rich in bioactive ingredients phenolics, including proanthocyanidins, flavonoids and anthocyanins. Phenolics have function regulating intestinal microbiota promoting health. From perspective dietary nutrition grape peel phenolics (GPP), present study aimed to investigate influence GPP on composition metabolism human gut during vitro fermentation.
Language: Английский
Citations
1