(−)-Epigallocatechin-3-gallate (EGCG) ameliorates ovalbumin-induced asthma by inhibiting inflammation via the TNF-α/TNF-R1/NLRP3 signaling pathway DOI
Beibei Zhang, Mengnan Zeng,

Qimei Tie

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113708 - 113708

Published: Dec. 3, 2024

Language: Английский

Exploring the regulation of metabolic changes mediated by different combined starter cultures on the characteristic flavor compounds and quality of Sichuan-style fermented sausages DOI

Buzhou Xu,

Weiqiang Qiu, Yuwei Liu

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116114 - 116114

Published: March 4, 2025

Language: Английский

Citations

0
1, 8-Cineole Ameliorated Staphylococcus aureus-Induced Pneumonia through Modulation of TRP-KYN and Arginine-NO Reprogramming DOI

Qianwen Cao,

Luyao Liu,

Xiaoge Ma

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

1, 8-Cineole (Cin), a cyclic monoterpenoid derived from tea trees and eucalyptus species, exhibits diverse pharmacological properties. Yet, its therapeutic impact underlying mechanism against Staphylococcus aureus (S. aureus) pneumonia remain to be elucidated. In this study, metabolomics based on UPLC-MS/MS was integrated with network pharmacology, molecular biology, docking investigate the effects of Cin. The findings demonstrated that Cin markedly reduced mortality lung bacterial load, lessened pulmonary damage while suppressing levels proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) infected mice. Additionally, 19 metabolites, primarily involved tryptophan metabolism arginine biosynthesis, were notably modified by via enzymatic activity indoleamine 2, 3-dioxygenase 1 (IDO1) inducible nitric oxide synthase (iNOS), thereby attenuating inflammatory response. Notably, knockdown IDO1 or iNOS significantly diminished anti-inflammation effect conclusion, our study validates potential S. downregulating iNOS. Our results provide theoretical basis natural substances applied treatment.

Language: Английский

Citations

0
Artemisia argyi essential oil alleviates asthma by regulating 5-LOX-CysLTs and IDO-1-KYN pathways: Insights from metabolomics DOI
Ying Rong, Mengqi Tang, Luyao Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118458 - 118458

Published: June 12, 2024

Language: Английский

Citations

2
(−)-Epigallocatechin-3-gallate (EGCG) ameliorates ovalbumin-induced asthma by inhibiting inflammation via the TNF-α/TNF-R1/NLRP3 signaling pathway DOI
Beibei Zhang, Mengnan Zeng,

Qimei Tie

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113708 - 113708

Published: Dec. 3, 2024

Language: Английский

Citations

1