International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137427 - 137427
Published: Nov. 12, 2024
Language: Английский
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Jan. 26, 2025
Abstract The incidence of obesity is increasing annually worldwide. A high-fat diet (HFD) causes intestinal barrier damage, but effective interventions are currently unavailable. Our previous work demonstrated the therapeutic effect nobiletin on obese mice; thus, we hypothesized that could reverse HFD-induced damage to barrier. Male C57BL/6 J mice were orally administered for 14 d. After identification, equally divided into three groups: HFD group, low-dose (NOL, 100 mg/kg/d) group and high-dose (NOH, 200 group. normal control (CON) was also included. Hematoxylin eosin (HE) staining immunofluorescence used observe RT-qPCR determine transcriptomic levels genes involved in integrity lipid metabolism. results revealed tight proteins, including ZO-1 Occludin, significantly reduced HFD-fed markedly restored after intervention, particularly NOH mice. Improvements metabolism associated with major histocompatibility complex class II (MHC-II) relevant elements intervention. Enrichment analysis MHC-II plays an important role restoration Taken together, by regulating expression.
Language: Английский
Citations
0
Current Research in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101049 - 101049
Published: April 1, 2025
Dysregulation of gut microbiota homeostasis can lead to various health issues. In this study, we investigated the effects tangeretin (TAN) on in a mouse model (C57BL/6J) disease, specifically focusing dextran sulfate sodium (DSS)-induced colitis and antibiotic-associated diarrhea through vitro fermentation intestinal bacteria. Our results demonstrated that TAN effectively improved diversity structure disordered microbiota, increasing levels beneficial bacteria such as Lachnospiraceae Bacteroidaceae, while decreasing harmful Enterococcaceae Pseudomonadaceae. Additionally, enhanced production short-chain fatty acids (SCFAs) microbial communities. Moreover, metabolism by microorganisms yielded two new metabolites, which exhibited an inverse-conjugate (deconjugate) role, leading more functional substances with high bioactivity. These findings provide scientific basis for potential use prebiotic regulate microbiota.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143383 - 143383
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118544 - 118544
Published: July 14, 2024
Language: Английский
Citations
3
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 138 - 138
Published: Feb. 1, 2025
Background/Objectives: Drug-induced dysbiosis, particularly from antibiotics, has emerged as a significant contributor to chronic diseases by disrupting gut microbiota composition and function. Plant-derived secondary metabolites, such polysaccharides, polyphenols, alkaloids, saponins, show potential in mitigating antibiotic-induced dysbiosis. This review aims consolidate evidence preclinical studies on the therapeutic effects of metabolites restoring microbial balance, emphasizing their mechanisms efficacy. Methods: A narrative was conducted using PubMed, Scopus, Web Science. Studies were selected based specific inclusion criteria, focusing animal models treated with for The search terms included “gut microbiota”, “antibiotics”, “secondary metabolites”. Data extraction focused alterations, metabolite-specific effects, action. Relevant findings systematically analyzed summarized. Results: Secondary demonstrated diverse impact dysbiosis modulating composition, reducing inflammation, supporting host biological markers. Polysaccharides polyphenols restored Firmicutes/Bacteroidetes ratio, increased beneficial taxa Lactobacillus Bifidobacterium, suppressed pathogenic bacteria like Escherichia-Shigella. Metabolites triterpenoid saponins enhanced barrier integrity upregulating tight junction proteins, while alkaloids reduced inflammation proinflammatory cytokines (e.g., TNF-α, IL-1β). These also improved short-chain fatty acid production, which is crucial systemic health. While primary focus, other drug classes PPIs, metformin) require further investigation. Conclusions: promise managing improving Future research should explore applicability types drug-induced validate human enhance clinical relevance.
Language: Английский
Citations
0
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24
Published: March 27, 2025
The gut barrier, composed of physical, secretory, immunological, and biological components, serves as the first line defense against external threats. commensal microbiota not only functions a barrier to maintain intestinal homeostasis but also produces metabolites that regulate integrity. Increasing evidence suggests dysfunction is linked gastrointestinal diseases, autoimmune disorders, neurological conditions. Plant food-derived bioactive components exhibit diverse bioactivities, including ability modulate improve function, potentially preventing chronic diseases. This review explores mechanisms underlying disruption caused by drugs, diet, pathogenic infections, alcohol. Additionally, it provides comprehensive summary beneficial effects specific plant on function homeostasis, along with their mechanisms. By elucidating these interactions, this offers valuable insights for developing safer, more effective, affordable plant-based strategies prevent or mitigate dysfunction. Understanding role compounds in health may contribute novel dietary interventions aimed at strengthening defenses reducing risk diseases associated impairment.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 4, 2025
Objective Moxifloxacin (MFLX) frequently induces dysglycemia when used in the treatment of infectious diseases, particularly patients with diabetes. However, mechanism through which MFLX affects host glucose metabolism remains unclear. This study aimed to investigate possible underlying MFLX-induced hyperglycemia. Methods In this study, we investigated short-term (3 days) and long-term (14 effects on normal type 2 diabetic GK rats. After oral administration 40 mg/kg MFLX, blood glucose, insulin, GLP-1, fibroblast growth factor 15 (FGF15) levels rats, as well bile acids both feces, gut microbiota, were examined. Liver ileum tissues promptly harvested for detecting expression hepatic 7α-hydroxylase (CYP7A1) intestinal Takeda G-protein-coupled receptor 5 (TGR5) farnesoid X (FXR). addition, explored effect secondary (SBAs) GLP-1 secretion NCI-H716 cells, observed direct CYP7A1 HepG2 cells TGR5, FXR cells. Results It was demonstrated that induced hyperglycemia a more pronounced reduction serum FGF15 than Gut microbiota associated SBAs significantly reduced, leading decreased deoxycholic acid (DCA) lithocholic (LCA). vitro studies revealed DCA LCA (25 μM, 50 100 μM) promoted concentration-dependent manner Meanwhile, TGR5 downregulated, whereas liver increased rats after treatment. itself (0.1 1 10 did not directly altered or expressions nor it alter indicated impact primarily by changes resulting from alterations microbiota. Conclusion Our showed likely cause states highlighted critical role microbiota-SBAs-TGR5/FXR pathway
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116354 - 116354
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137427 - 137427
Published: Nov. 12, 2024
Language: Английский
Citations
1