Highly Diastereoselective Synthesis of Multifunctionalized Dihydrofurans by a K3PO4‐Promoted Michael Addition‐Alkylation Reaction DOI

Juhua Feng,

Jinxiang Feng,

Juanhong Li

et al.

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(37)

Published: Oct. 6, 2023

Abstract A simple and beneficial strategy for the construction of 2,3‐dihydrofurans from α‐bromochalcones α‐substituted cyanoketones via Michael addition‐alkylation reaction has been realized. This transformation was well compatible with various cyanoketones, corresponding multifunctionalized were obtained in up to 98 % yield. highly diastereoselective variant also developed. Moreover, could be performed on gram‐scale.

Language: Английский

Catalytic Asymmetric Dearomative Arylation of 2‐Naphthols Enabled by o‐Quinone Diimides DOI

Yuan‐Yang Li,

Fu‐Yuan Yang,

Meng‐Yuan Wu

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(20), P. 4238 - 4243

Published: March 16, 2024

Abstract The catalytic asymmetric dearomative arylation of 2‐naphthols enabled by the unconventional reactivity o ‐quinone diimides, i. e. 1,4‐conjugate addition on quinone sp 2 hybridized carbon, has been established. Under catalysis chiral phosphoric acid, various cyclohexaenones bearing an all‐carbon quaternary stereocenter have prepared with excellent yields and enantioselectivities.

Language: Английский

Citations

5
Nucleophile-Controlled Regiodivergent Domino Reactions of Enetriones with γ-Bromocrotonates: Access to 1,3-Dienic Esters and Tetrasubstituted Pyrans DOI

Dan Xiong,

Sen Zhang, Zhiyue Li

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Herein, we developed an efficient nucleophile-controlled regiodivergent domino reaction between enetriones and γ-bromocrotonates. This method allowed for the rapid synthesis of a range 1,3-dienic esters tetrasubstituted pyrans under metal-free conditions. In presence pyridine, SN2 substitution/Michael addition/elimination sequence formed in satisfactory yields with high E-stereoselectivities. Alternatively, addition/cyclization/cyclopropanation/cyclopropane ring-opening process forged good help Et3N. It is interesting to note that site-selective reactions γ-bromocrotonates at α- or γ-position were readily realized by modulating pyridine Furthermore, simple Et3N act as both nucleophiles substitution Lewis bases deprotonation processes.

Language: Английский

Citations

0
A pH-regulated fluorescence covalent organic framework for quantitative water content detection in methanol DOI
Yuxin Ma,

Zheng-Fen Pu,

Jin-Zhou Liu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 313, P. 124140 - 124140

Published: March 8, 2024

Language: Английский

Citations

2
Diastereodivergent and Regioselective Synthesis of Tetrahydrofuro[2,3-b]furans with Four Consecutive Stereocenters DOI
Jing Zhang,

Wen‐Na Sun,

Zhiwei Jiang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 4134 - 4144

Published: Feb. 23, 2024

Base-catalyzed diastereodivergent and regioselective domino processes of triketone enones with arylacetaldehydes for the synthesis tetrahydrofuro[2,3-

Language: Английский

Citations

1
Rare demethylation of 4-benzylidene-2-phenyloxazolone DOI

Maokai Jiang,

Yuankun Wang,

Yumeng Zhuang

et al.

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(11), P. 909 - 917

Published: May 10, 2024

This study presents a novel and rare demethylation of 4-benzylidene-2-phenyloxazolones under NaOH/EtOH/H2O conditions. The potential mechanism underlying the phenomenon was evaluated through control reactions.

Language: Английский

Citations

0
Organocatalytic asymmetric cyclization of aminochalcones and azlactones: synthesis of 3,4-dihydroquinolinones DOI Creative Commons
Xuerui Wang, Weiwu Ren

Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
A Ph-Regulated Fluorescent Covalent Organic Framework for Quantitative Water Content Detection in Methanol DOI
Yuxin Ma,

Zheng-Fen Pu,

Jin-Zhou Liu

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Highly Diastereoselective Synthesis of Multifunctionalized Dihydrofurans by a K3PO4‐Promoted Michael Addition‐Alkylation Reaction DOI

Juhua Feng,

Jinxiang Feng,

Juanhong Li

et al.

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(37)

Published: Oct. 6, 2023

Abstract A simple and beneficial strategy for the construction of 2,3‐dihydrofurans from α‐bromochalcones α‐substituted cyanoketones via Michael addition‐alkylation reaction has been realized. This transformation was well compatible with various cyanoketones, corresponding multifunctionalized were obtained in up to 98 % yield. highly diastereoselective variant also developed. Moreover, could be performed on gram‐scale.

Language: Английский

Citations

0