Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 6, 2024
Abstract
A
visible‐light‐induced
radical
tandem
difluoroalkylation/cyclization
to
construct
CF
2
‐containing
isoquinolinonedione
skeletons
with
methacryloyl
benzamides
is
developed.
Broad
substrate
scopes
are
compatible
metal‐,
oxidant‐
and
photocatalyst‐free
conditions
under
room
temperature
in
good‐to‐excellent
yields.
Mechanistic
analysis
revealed
that
the
transformation
initiated
by
photoinduced
electron
donor‐acceptor
(EDA)
complexes
formation.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(4), P. 1072 - 1077
Published: Jan. 18, 2025
A
Cu(I)
photoredox-enabled
reaction
that
selectively
incorporates
a
difluoroalkyl
group
into
N-aryl
glycine
derivatives
has
been
established.
Using
bench-stable
[Ph3PCF2H]+Br-
salt,
the
-CF2H
could
be
installed
either
directly
on
α-carbon
of
backbone
or
in
three-component
fashion
using
an
alkene
as
bridge.
series
have
evaluated,
providing
access
to
diverse
unnatural
amino
esters
and
dipeptides
with
-CHF2
unit.
The
studies
compatibility
other
perfluorinated
alkyl
radical
precursors
showed
selectivity
direct
α-coupling
is
closely
associated
electronic
property
radical,
while
works
well
most
cases.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Herein,
a
N-phenylphenothiazine-based
hyper-cross-linked
polymer
(PTH-HCP)
was
finely
designed
and
constructed,
which
serves
as
metal-free
heterogeneous
photocatalyst
for
organic
transformations.
Characterization
experiments
have
shown
that
this
demonstrates
outstanding
stability,
extensive
surface
area,
exceptional
photoelectric
response
properties.
Moreover,
PTH-HCP
showed
good
catalytic
efficiency
recyclability
in
the
photochemically
driven
difluoromethylation/cyclization
reactions.
This
work
provides
strategy
design
construction
of
photocatalysts
offers
support
their
broad
prospects
synthetic
applications.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(5), P. 1158 - 1164
Published: Jan. 10, 2024
Abstract
A
visible‐light‐promoted
cascade
difluoromethylation/cyclization
reaction
to
access
various
difluoromethylated
pyrrolo[1,2‐
a
]indolediones
was
developed
using
difluoromethyltriphenylphosphonium
bromide
salt
as
the
difluoromethylating
reagent.
possible
radical
mechanism
has
been
investigated
and
proven
single
electron
transfer
(SET)
procedure.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(26), P. 28129 - 28143
Published: June 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(31)
Published: June 5, 2024
Abstract
During
the
past
decade,
radical
difluoromethylation
has
emerged
as
a
powerful
and
versatile
tool
for
incorporation
of
difluoromethyl
into
various
organic
compounds.
These
reactions
feature
mild
reaction
conditions,
very
good
functional
group
compatibilities,
quite
broad
substrate
scopes,
thus
having
drawn
much
attention
got
rapid
developments.
A
diverse
range
precursors
have
been
developed
series
reactions.
This
review
summarizes
discusses
advance
in
reactions,
which
are
organized
according
to
protocols
generating
radical.
Green Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
first
method
for
constructing
pyrido[3,2-
c
]coumarin
derivatives
via
a
radical
cascade
cyclization
process
was
proposed,
which
can
introduce
active
fragments.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
We
have
successfully
developed
a
novel
synthetic
route
for
the
synthesis
of
α,β‐unsaturated‐azo‐substituted‐quinazolin‐2(1
H
)‐one
via
reaction
between
1,3‐diphenylurea
analogues
and
diazonium
salts,
facilitated
by
salt‐induced
intramolecular
cyclization
process.
Notably,
this
exhibits
remarkable
tolerance
toward
wide
range
substituents,
resulting
in
formation
diverse
products
under
mild
conditions.
Additionally,
we
discovered
that
rearrangement
occurs
alkaline
conditions,
leading
to
α,β‐unsaturated‐azo‐substituted‐quinolinone
derivatives.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
This
study
describes
an
efficacious
and
generally
applicable
synthetic
strategy
for
the
incorporation
of
biologically
physiologically
prominent
difluoromethyl
entity
into
synthetically
crucial
hydrazone
scaffolds
with
bench-stable
easily
accessible
difluoromethyltriphenylphosphonium
bromide.
The
broad
substrate
scope,
excellent
functional
group
compatibility,
feasibility
step
atom
economical
one-pot
manipulation,
environmentally
benign
mild
reaction
conditions
rendered
this
methodology
efficient
tool
preparation
pharmaceutically
fluorine-containing
imino
compounds.
