GreenMedChem-Inspired Light-Air Mediated C(sp3)-H Bond Oxidation: A New tool for Isoquinolone Synthesis DOI
Qi Zhang, Wenbing Dai, Da‐Le Guo

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117414 - 117414

Published: Feb. 19, 2025

Language: Английский

Catalytic Fluorination of α-Branched Ketones with Nucleophilic Fluorine DOI

Shengyu Zhong,

Zhiyou Yu,

Yueying Zhu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

We herein disclose the first example of metal-free, redox-umpolung-enabled catalytic fluorination α-branched ketones with nucleophilic fluorine by judicious choice an oxidant. The strategic use cyclopropyl malonoyl peroxide in hypervalent iodine(III) catalysis expands modularity and generality construction α-fluorinated ideally orthogonal reactivity space, avoiding competing oxidation processes. Characteristic for this transformation is its operational simplicity, mild reaction conditions, gram-scale synthetic ability.

Language: Английский

Citations

0
GreenMedChem-Inspired Light-Air Mediated C(sp3)-H Bond Oxidation: A New tool for Isoquinolone Synthesis DOI
Qi Zhang, Wenbing Dai, Da‐Le Guo

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117414 - 117414

Published: Feb. 19, 2025

Language: Английский

Citations

0