Transition-metal-, oxidant- and additive-free multi-component synthesis of alkyl heteroaryl BCPs enabled by visible-light-induced phosphine-catalyzed halogen-atom transfer

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This study describes a pioneering visible-light-induced phosphine-catalyzed halogen-atom transfer (XAT) strategy that heralds new era in the difunctionalization of [1.1.1]propellane.

Language: Английский

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Visible-Light-Induced C–H Cyanoalkylation of Azauracils with Cycloketone Oxime Esters via Catalytic EDA Complex

Organic Letters, Journal Year: 2024, Volume and Issue: 26(18), P. 3727 - 3732

Published: April 28, 2024

Photoexcitation electron donor-acceptor (EDA) complexes provide an effective approach to produce radicals under mild conditions, while the catalytic version of EDA complex photoactivation remains scarce. Herein, we report a visible-light-induced organophotocatalytic pathway for cyanoalkylation azauracils using inexpensive and readily available 1,4-diazabicyclo[2.2.2]octane (DABCO) as donor. This synthetic method exhibits exceptional compatibility with various functional groups presents 34 examples in high yields. The efficient offers environmentally friendly sustainable route toward enhancing structural diversity azauracils.

Language: Английский

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Multi-objective optimization of Fe-based SCR catalyst on the NOx conversion efficiency for a diesel engine based on FGRA-ANN/RF

Energy, Journal Year: 2024, Volume and Issue: 294, P. 130899 - 130899

Published: March 13, 2024

Language: Английский

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Overview of the impact of oxygenated biofuel additives on soot emissions in laboratory scale

Fuel Processing Technology, Journal Year: 2024, Volume and Issue: 254, P. 108046 - 108046

Published: Jan. 30, 2024

Soot has harmful effects on the environment and human health. The formation process of soot includes six steps: fuel pyrolysis, nucleation, coalescence, surface growth, aggregation, oxidation. However, is very complex influenced by factors such as type, combustion conditions, environmental temperature. Oxygenated fuels additives have a positive effect reducing emissions, but recent studies shown that oxygenated can lead to an increase in number small particles soot. In this paper, alcohol, ether, esters emissions discussed terms mechanism formation. Subsequently, role after-treatment systems summarized. This work update our understanding impact emissions.

Language: Английский

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Electrochemical C–H Alkylation of Azauracils Using N-(Acyloxy)phthalimides

Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7227 - 7232

Published: Aug. 20, 2024

We present an electrochemical alkylation of azauracils using N-(acyloxy)phthalimides (NHPI esters) as readily available alkyl radical progenitors under metal- and additive-free conditions. Several are shown to undergo with array NHPI esters (1°, 2°, 3°, sterically congested), providing the desired products in good excellent yields. This operationally simple method is robust, scalable, suitable for both batch flow setups.

Language: Английский

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Adamantane-Quinoxalone Hybrids: Precision Chemotypes and Their Molecular Mechanisms in Acute Myeloid Leukemia

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis, especially when diagnosed late. Around 10–15% of cases involve the specific chromosomal abnormality t(8;21), which drives uncontrolled cell proliferation and contributes to disease onset. Despite advances in AML research treatment protocols, outcomes for t(8;21) remain stagnant, as patients receive standard, nonspecific chemotherapies. This one-size-fits-all approach targets both cancerous healthy cells, leading unwanted toxicity highlighting urgent need targeted therapies. In this study, we present precision chemotype based on quinoxalone-tethered adamantane framework developed via metal- light-free protocol. The compound selectively inhibits induces death by disrupting growth metabolic pathways, demonstrated through bioassays, RNA sequencing, proteomic analysis. Notably, it spares other leukemic solid underscoring its specificity potential therapy AML.

Language: Английский

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Improvement of the light-load combustion control strategy for a heavy-duty diesel engine fueled with diesel/methonal by RSM-NSGA III

Energy, Journal Year: 2024, Volume and Issue: 297, P. 131190 - 131190

Published: April 5, 2024

Language: Английский

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Recyclable V₂O₅/g-C₃N₄ Heterojunction-Catalyzed Visible-Light-Promoted C3–H Trifluoromethylation of Quinoxalin-2-(1H)-ones

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(13), P. 9543 - 9550

Published: June 14, 2024

A visible-light-initiated C-H trifluoromethylation of quinoxalin-2(1

Language: Английский

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Overview of mechanisms of Fe-based catalysts for the selective catalytic reduction of NOx with NH3 at low temperature

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(10), P. 14424 - 14465

Published: Jan. 31, 2024

Language: Английский

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Minisci‐Type Carbamoylation of Azauracils with Oxamic Acids

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(7)

Published: Jan. 19, 2024

Abstract A Minisci‐type carbamoylation of azauracils was developed to afford 6‐carbamoyl in yields up 94 %. In this transformation, oxamic acids were employed as the carbamoyl radical sources under metal‐free conditions. It features high atom economy, good functional group compatibility and convenient operation.

Language: Английский

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