Abstract
A
photocatalytic
methodology
has
been
devised
for
the
stereoselective
construction
of
trisubstituted
alkenes
incorporating
3,3‐difluoro‐γ‐lactams
in
17–93%
yields
via
a
radical
cascade
process
utilizing
MBH
acetates
and
N
‐allylbromodifluoroacetamides
as
starting
materials.
The
reaction
mechanism
involves
single‐electron
transfer,
5
‐
exo
trig
cyclization,
addition,
elimination
fashion.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1683 - 1696
Published: Jan. 17, 2025
In
the
vanguard
of
sustainable
chemistry,
pursuit
efficient
pathways
for
synthesis
alkyl
bicyclo[1.1.1]pentane-heteroaryls
has
captured
attention
scientific
vanguard.
We
herein
report
a
groundbreaking
and
eco-conscious
multicomponent
coupling
reaction
that
paves
way
alkylation
heteroarylation
[1.1.1]propellane,
process
uniquely
enabled
by
photochemical
prowess
an
electron
donor–acceptor
(EDA)
complex.
This
method
is
distinguished
its
minimalist
yet
powerful
approach:
devoid
transition
metals,
additives,
photosensitizers.
Its
universality
further
exemplified
seamless
compatibility
broad
spectrum
halides
heteroarenes
under
standardized
conditions,
heralding
new
era
synthetic
versatility.
The
method's
practicality
underscored
capacity
late-stage
modification
pharmaceuticals,
offering
transformative
tool
enhancement
existing
drug
molecules.
Moreover,
facile
derivatization
synthesized
products
underscores
adaptability
potential
diverse
applications.
Our
mechanistic
studies
have
elucidated
underlying
radical-relay
pathway,
pinpointing
pivotal
role
EDA
complex
in
initiating
transformation.
discovery
not
only
enriches
our
fundamental
understanding
but
also
opens
avenues
strategic
optimization.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Herein,
a
N-phenylphenothiazine-based
hyper-cross-linked
polymer
(PTH-HCP)
was
finely
designed
and
constructed,
which
serves
as
metal-free
heterogeneous
photocatalyst
for
organic
transformations.
Characterization
experiments
have
shown
that
this
demonstrates
outstanding
stability,
extensive
surface
area,
exceptional
photoelectric
response
properties.
Moreover,
PTH-HCP
showed
good
catalytic
efficiency
recyclability
in
the
photochemically
driven
difluoromethylation/cyclization
reactions.
This
work
provides
strategy
design
construction
of
photocatalysts
offers
support
their
broad
prospects
synthetic
applications.
Green Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
first
method
for
constructing
pyrido[3,2-
c
]coumarin
derivatives
via
a
radical
cascade
cyclization
process
was
proposed,
which
can
introduce
active
fragments.
New Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
novel
approach
for
constructing
3,4-difunctionalized
benzo[
h
]coumarins
through
a
metal-free
multicomponent
reactions
with
mild
reaction
conditions.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(46), P. 9973 - 9977
Published: Nov. 14, 2024
Herein,
we
disclose
a
readily
available
phenothiazine
derivative
as
an
organocatalyst,
which
upon
excitation
with
371
nm
light
acquires
strongly
reducing
power
and
serves
to
induce
the
radical
cascade
difluoromethylation/cyclization
reaction
of
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Comprehensive
Summary
Herein,
we
report
a
rare
example
of
three‐component
net‐oxidative
sulfonylation
SO
2
surrogate
with
an
oxidatively
activated
radical
precursor
under
mild
and
metal‐
external‐oxidant‐free
conditions.
The
mildness
sustainability
the
reaction
are
enabled
by
photoelectrocatalysis,
3‐aza‐1,5‐dienes,
organotrifluoroborates
1,4‐diazabicyclo[2.2.2]octane
bis(sulfur
dioxide)
adduct
(DABSO)
undergo
sulfonylative
cyclization
to
afford
sulfono
4‐pyrrolin‐2‐ones
in
atom‐economical
manner
broad
substrate
scope
good
functional‐group
tolerance.
protocol
is
amenable
late‐stage
diversification
complex
molecular
architectures
as
well
gram‐scale
synthesis.
Sunlight
could
be
used
light
source,
conducted
all‐solar
mode
using
commercially
available
photovoltaic
panel
generate
electricity
situ
.
Mechanistic
studies
reveal
that
generated
(DABCO),
which
was
generally
innocent
previous
reactions,
functions
electron
shuttle
between
photocatalytic
cycle
reactants.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
A
method
was
found
to
construct
sulfur-containing
five-
and
six-membered
heterocyclic
alkyl
sulfonyl
compounds
by
using
visible
light
free
radicals
activated
and/or
generated
EDA
complexes/homolytic
cleavage
as
initiators
stimulate
the
relay
reaction
of
alkynes/alkynones.
This
puts
forward
a
new
strategy
initiate
sulfonation
alkynes/alkynones
with
only
catalytic
amount
initiator.
generating
initiator
complex
activation/homolytic
provides
idea
for
following
substances
that
must
be
excited.
