Biomicrofluidics,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Jan. 1, 2025
Atmospheric
ice-nucleating
particles
(INPs)
make
up
a
vanishingly
small
proportion
of
atmospheric
aerosol
but
are
key
to
triggering
the
freezing
supercooled
liquid
water
droplets,
altering
lifetime
and
radiative
properties
clouds
having
substantial
impact
on
weather
climate.
However,
INPs
notoriously
difficult
model
due
lack
information
their
global
sources,
sinks,
concentrations,
activity,
necessitating
development
new
instrumentation
for
quantifying
characterizing
in
rapid
automated
manner.
Microfluidic
technology
has
been
increasingly
adopted
by
ice
nucleation
research
groups
recent
years
as
means
performing
droplet
analysis
INPs,
enabling
measurement
hundreds
or
thousands
droplets
per
experiment
at
temperatures
down
homogeneous
water.
The
potential
microfluidics
extends
far
beyond
this,
with
an
entire
toolbox
bioanalytical
separation
detection
techniques
developed
over
30
medical
applications.
Such
methods
could
easily
be
adapted
biological
biogenic
INP
revolutionize
field,
example,
identification
quantification
bacteria
fungi.
Combined
miniaturized
sampling
techniques,
we
can
envisage
deployment
microfluidic
sample-to-answer
platforms
automated,
user-friendly
field
that
would
enable
greater
understanding
seasonal
activity.
Here,
review
various
components
such
platform
incorporate
highlight
feasibility,
challenges,
endeavor,
from
assays
separations
bioanalysis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 21, 2024
Miniaturized
droplets,
characterized
by
well-controlled
microenvironments
and
capability
for
parallel
processing,
have
significantly
advanced
the
studies
on
enzymatic
evolution,
molecular
diagnostics,
single-cell
analysis.
However,
manipulation
of
small-sized
including
moving,
merging,
trapping
targeted
droplets
complex
biochemical
assays
subsequent
analysis,
is
not
trivial
remains
technically
demanding.
Among
various
techniques,
light-driven
methods
stand
out
as
a
promising
candidate
droplet
in
facile
flexible
manner,
given
features
contactless
interaction,
high
spatiotemporal
resolution,
biocompatibility.
This
review
therefore
compiles
an
in-depth
discussion
governing
mechanisms
underpinning
manipulation.
Besides,
light-responsive
materials,
representing
core
light-matter
interaction
key
character
converting
light
into
different
forms
energy,
are
particularly
assessed
this
review.
Recent
advancements
materials
most
notable
applications
comprehensively
archived
evaluated.
Continuous
innovations
rational
engineering
expected
to
propel
development
manipulation,
equip
with
enhanced
functionality,
broaden
routine
investigations.
Applied Physics Reviews,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Jan. 21, 2025
Droplet
microfluidics
has
emerged
as
highly
relevant
technology
in
diverse
fields
such
nanomaterials
synthesis,
photonics,
drug
delivery,
regenerative
medicine,
food
science,
cosmetics,
and
agriculture.
While
significant
progress
been
made
understanding
the
fundamental
mechanisms
underlying
droplet
generation
microchannels
fabricating
devices
to
produce
droplets
with
varied
functionality
high
throughput,
challenges
persist
along
two
important
directions.
On
one
side,
generalization
of
numerical
results
obtained
by
computational
fluid
dynamics
would
be
deepen
comprehension
complex
physical
phenomena
microfluidics,
well
capability
predicting
device
behavior.
Conversely,
truly
three-dimensional
architectures
enhance
microfluidic
platforms
terms
tailoring
enhancing
flow
properties.
Recent
advancements
artificial
intelligence
(AI)
additive
manufacturing
(AM)
promise
unequaled
opportunities
for
simulating
behavior,
precisely
tracking
individual
droplets,
exploring
innovative
designs.
This
review
provides
a
comprehensive
overview
recent
applying
AI
AM
microfluidics.
The
basic
properties
multiphase
flows
production
are
discussed,
current
fabrication
methods
related
introduced,
together
their
applications.
Delving
into
use
technologies
topics
covered
include
AI-assisted
simulations
real-time
within
systems,
AM-fabrication
systems.
synergistic
combination
is
expected
active
matter
expediting
transition
toward
fully
digital
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Centrifugal
microfluidics,
with
its
advantages
of
rapid
and
precise
fluid
control
without
the
need
for
external
pressure,
is
widely
applied
in
point-of-care
testing.
Biosensors and Bioelectronics,
Journal Year:
2024,
Volume and Issue:
263, P. 116632 - 116632
Published: Aug. 3, 2024
Microfluidic
devices
are
increasingly
widespread
in
the
literature,
being
applied
to
numerous
exciting
applications,
from
chemical
research
Point-of-Care
devices,
passing
through
drug
development
and
clinical
scenarios.
Setting
up
these
microenvironments,
however,
introduces
necessity
of
locally
controlling
variables
involved
phenomena
under
investigation.
For
this
reason,
literature
has
deeply
explored
possibility
introducing
sensing
elements
investigate
physical
quantities
biochemical
concentration
inside
microfluidic
devices.
Biosensors,
particularly,
well
known
for
their
high
accuracy,
selectivity,
responsiveness.
However,
signals
could
be
challenging
interpret
must
carefully
analysed
carry
out
correct
information.
In
addition,
proper
data
analysis
been
demonstrated
even
increase
biosensors'
mentioned
qualities.
To
regard,
machine
learning
algorithms
undoubtedly
among
most
suitable
approaches
undertake
job,
automatically
highlighting
biosensor
signals'
characteristics
at
best.
Interestingly,
it
was
also
benefit
themselves,
a
new
paradigm
that
is
starting
name
"intelligent
microfluidics",
ideally
closing
benefic
interaction
disciplines.
This
review
aims
demonstrate
advantages
triad
microfluidics-biosensors-machine
learning,
which
still
little
used
but
great
perspective.
After
briefly
describing
single
entities,
different
sections
will
benefits
dual
interactions,
applications
where
reviewed
employed.
ChemElectroChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Abstract
Microfluidic
technology
has
exhibited
remarkable
potential
and
significance
in
the
precise
preparation
of
multifunctional
nanomaterials.
Thanks
to
its
small
reaction
volume
superior
hydrodynamic
control,
this
emerged
as
an
essential
tool
for
synthesizing
nanomaterials
with
precisely
tunable
microstructures
morphologies.
This
paper
reviews
latest
advancements
controllable
synthesis
metal
nano‐electrocatalysts
utilizing
microfluidic
technology.
Firstly,
it
systematically
elucidates
fundamental
principles
distinctive
parameter
control
strategies.
Subsequently,
delves
deeply
into
mechanism
enhancement
process
nanoparticles
environment.
Through
analysis
specific
cases,
extensive
application
prospects
advantages
system
have
been
further
elucidated.
Finally,
summarizes
looks
forward
challenges
future
development
directions
that
faces
nano‐electrocatalysts.
review
aims
provide
valuable
insights
morphology
design
technological
innovation
electrocatalysts.
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
focuses
on
droplets
in
open
microfluidics,
covering
their
generation,
manipulation
and
application
cell
analysis.
It
could
serve
as
a
comprehensive
guide
for
readers
to
understand
explore
droplet
systems.
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
human
microbiome
is
vital
for
health.
Droplet
microfluidics
offers
a
versatile
toolbox
research,
enabling
single-cell
sequencing,
cultivation,
and
functional
analyses
to
deepen
our
understanding
drive
innovations.
Micromachines,
Journal Year:
2025,
Volume and Issue:
16(2), P. 132 - 132
Published: Jan. 24, 2025
Step
emulsification
(SE)
is
renowned
for
its
robustness
in
generating
monodisperse
emulsion
droplets
at
arrayed
nozzles.
However,
few
studies
have
explored
poly(dimethylsiloxane)
(PDMS)-based
SE
devices
producing
oil-in-water
(O/W)
and
polymeric
microspheres
with
diameters
below
20
µm-materials
broad
applicability.
In
this
study,
we
present
a
PDMS-based
microfluidic
device
designed
to
achieve
goal.
Two
264
nozzles
each
were
fabricated,
featuring
straight
triangular
nozzle
configurations,
both
height
of
4
µm
minimum
width
10
µm.
The
rendered
hydrophilic
via
oxygen
plasma
treatment.
A
photocurable
acrylate
monomer
served
as
the
dispersed
phase,
while
an
aqueous
polyvinyl
alcohol
solution
acted
continuous
phase.
produced
polydisperse
exceeding
30
coefficient-of-variation
(CV)
values
above
10%.
contrast,
nozzles,
opening
38
µm,
consistently
generated
CVs
4%,
maximum
throughput
0.5
mL
h-1.
Off-chip
photopolymerization
these
yielded
acrylic
microspheres.
low-cost,
disposable,
scalable
offers
significant
potential
applications
spanning
from
laboratory-scale
research
industrial-scale
particle
manufacturing.