Development of a PMMA-based Droplet microfluidic device for High-throughput Screening in Health care Applications DOI

K.K. Purushothaman,

Ashwin Kumar Narasimhan,

S Gnanavel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract The research focuses on the development of a novel, cost-effective, three-layer droplet microfluidic device fabricated using Polymethyl methacrylate (PMMA) engineered for high-throughput screening in healthcare applications. PMMA offered improved optical transparency, chemical resistance, low absorption, and high scalability. Here, we evolved T-junction integrated microchannel with squeezer mechanism consistent monodisperse generation. Device fabrication was achieved via laser ablation technique followed by an ethanol-enhanced UV-irradiation method strong leak-free bonding between layers. surface properties layer revealed increased energy uniform wettability. tensile strength devices demonstrated superior structural integrity compared to existing methods. reliably generated droplets up 100 ml/hr flow rate, confirming its robustness suitability screening. Overall, this PMMA-based Microfluidics platform offers scalable reliable solution generation suitable applications such as drug delivery, single-cell analysis, diagnostic assays.

Language: Английский

Droplet generation in a flow-focusing microchannel with continuous phase perturbations DOI

Keqing Lu,

Bo Huang, Zhanfeng Chen

et al.

European Journal of Mechanics - B/Fluids, Journal Year: 2025, Volume and Issue: unknown, P. 204278 - 204278

Published: April 1, 2025

Language: Английский

Citations

0
Controlled preparation of hollow n-Al/Fe2O3 MICs microspheres by two-droplet microfluidic technique and performance study DOI
Tong Wang, Jiawei Li,

Jiafei Li

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Impact of Carreau-Yasuda fluid properties on droplet dynamics in bifurcation microchannels DOI

Chen Hua,

Belgacem Bouallègue

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(4)

Published: April 1, 2025

This study investigates the three-dimensional dynamics of droplet splitting in bifurcation microchannels using a two-phase flow simulation with Level Set method implemented COMSOL Multiphysics, capturing behavior Carreau-Yasuda non-Newtonian fluid. The influence fluid properties, size, velocity, and channel geometry on process are systematically analyzed. results reveal three distinct regimes: cutting gap, without no-cutting, determined by length conditions. Higher sodium carboxymethyl cellulose concentrations (0.80%) increase viscosity, promoting even at shorter lengths (ε ≈ 1.0), while lower require longer droplets 2.0) for efficient splitting. Increased velocity enhances inducing pronounced viscosity variations, velocities hinder complete separation. Channel also plays significant role, 60° angle generating higher shear stresses more than 120° angle. These findings provide valuable insights optimizing microfluidic systems, offering practical strategies applications requiring precise control, such as drug delivery biochemical analysis. work contributes to advancing next-generation device design fine-tuning achieve manipulation.

Language: Английский

Citations

0
Elevating single-particle encapsulation in droplets microfluidics by utilizing surface acoustic wave and flow control DOI
Chunhua He, Huasheng Zhuo,

Canfeng Yang

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A microfluidic system integrating SAW technology and sheath flow control was developed for efficient particle encapsulation, featuring hydrodynamic pre-focusing, acoustic focusing, spatial adjustment, droplet generation functions.

Language: Английский

Citations

0
Development of a PMMA-based Droplet microfluidic device for High-throughput Screening in Health care Applications DOI

K.K. Purushothaman,

Ashwin Kumar Narasimhan,

S Gnanavel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract The research focuses on the development of a novel, cost-effective, three-layer droplet microfluidic device fabricated using Polymethyl methacrylate (PMMA) engineered for high-throughput screening in healthcare applications. PMMA offered improved optical transparency, chemical resistance, low absorption, and high scalability. Here, we evolved T-junction integrated microchannel with squeezer mechanism consistent monodisperse generation. Device fabrication was achieved via laser ablation technique followed by an ethanol-enhanced UV-irradiation method strong leak-free bonding between layers. surface properties layer revealed increased energy uniform wettability. tensile strength devices demonstrated superior structural integrity compared to existing methods. reliably generated droplets up 100 ml/hr flow rate, confirming its robustness suitability screening. Overall, this PMMA-based Microfluidics platform offers scalable reliable solution generation suitable applications such as drug delivery, single-cell analysis, diagnostic assays.

Language: Английский

Citations

0