The use of microphysiological systems to model metastatic cancer DOI Creative Commons
Caitlin E. Jackson, Nicola Green, William English

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(3), P. 032002 - 032002

Published: April 5, 2024

Abstract Cancer is one of the leading causes death in 21st century, with metastasis cancer attributing to 90% cancer-related deaths. Therefore, improve patient outcomes there a need for better preclinical models increase success translating oncological therapies into clinic. Current traditional static vitro lack perfusable network which critical overcome diffusional mass transfer limit provide mechanism exchange essential nutrients and waste removal, their physiological relevance. Furthermore, these typically cellular heterogeneity key components immune system tumour microenvironment. This review explores rapidly developing strategies utilising microphysiological systems (MPS) investigating cell metastasis. In this we initially outline mechanisms metastasis, highlighting steps identifying current gaps our understanding metastatic cascade, exploring MPS focused on individual cascade before detailing latest can investigate multiple cascade. then focuses factors affect performance an designed applications final discussion summarising challenges future directions use models.

Language: Английский

Regulation of metastatic organotropism DOI
Karen J. Dunbar, Gizem Efe, Katherine Cunningham

et al.

Trends in cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

4
Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment DOI Creative Commons

Guixiu Xiao,

Xinmin Wang,

Zihan Xu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 16, 2025

Language: Английский

Citations

0
An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models DOI

Pratibha Parihar,

Naina Sunildutt,

Chethikkattuveli Salih Abdul Rahim

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(6)

Published: Feb. 22, 2024

Abstract Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer faithful representation of cancer vitro, exploration biology, evaluation drug efficacy, and anticipation patient responses therapies. Compared conventional ones, VToC systems hold advantages by creating milieu where physiological conditions for investigating tumor–host interactions pivotal advancement/therapy resilience. Nevertheless, models confront limitations encompassing vascular network replication, biological fidelity, mechanical/chemical integrity, intricacies architectural design. Thus, drawbacks inherent prevailing models’ intricacies, attributes, establishment imperative. This systematic review focuses the recent advancements, technologies explored incorporating models, vascularization approaches investigation, factors/parameters affecting complex microenvironments along with futuristic approach design strategies, fabrication techniques, understanding network, also spheroid. A comprehensive analysis based their practical highlights promising strategies possible applications. will be essential regarding complete overview future direction toward developing efficient compared state‐of‐the‐art VToC.

Language: Английский

Citations

3
The use of microphysiological systems to model metastatic cancer DOI Creative Commons
Caitlin E. Jackson, Nicola Green, William English

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(3), P. 032002 - 032002

Published: April 5, 2024

Abstract Cancer is one of the leading causes death in 21st century, with metastasis cancer attributing to 90% cancer-related deaths. Therefore, improve patient outcomes there a need for better preclinical models increase success translating oncological therapies into clinic. Current traditional static vitro lack perfusable network which critical overcome diffusional mass transfer limit provide mechanism exchange essential nutrients and waste removal, their physiological relevance. Furthermore, these typically cellular heterogeneity key components immune system tumour microenvironment. This review explores rapidly developing strategies utilising microphysiological systems (MPS) investigating cell metastasis. In this we initially outline mechanisms metastasis, highlighting steps identifying current gaps our understanding metastatic cascade, exploring MPS focused on individual cascade before detailing latest can investigate multiple cascade. then focuses factors affect performance an designed applications final discussion summarising challenges future directions use models.

Language: Английский

Citations

1