Engineered two-dimensional nanomaterials based diagnostics integrated with internet of medical things (IoMT) for COVID-19
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 3774 - 3828
Published: Jan. 1, 2024
Engineered
2D
nanomaterials-based
smartphone-assisted
detection
approaches
integrated
with
IoMT,
focusing
on
reliable,
sensitive,
and
rapid
diagnostics
for
COVID-19.
Language: Английский
Hydroxyapatite-Gold Modified Screen-Printed Carbon Electrode for Selective SARS-CoV-2 Antibody Immunosensor
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(2), P. 950 - 960
Published: Feb. 2, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
or
disease
2019
(COVID-19),
is
still
spreading
worldwide;
therefore,
the
need
for
rapid
and
accurate
detection
methods
remains
relevant
to
maintain
spread
of
this
infectious
disease.
Electrochemical
immunosensors
are
an
alternative
method
SARS-CoV-2
virus.
Herein,
we
report
development
a
screen-printed
carbon
electrode
immunosensor
using
hydroxyapatite-gold
nanocomposite
(SPCE/HA-Au)
directly
spray-coated
with
immobilization
receptor
binding
domain
(RBD)
Spike
increase
conductivity
surface
area.
The
HA-Au
composite
synthesis
was
optimized
Box–Behnken
method,
resulting
characterized
by
UV–vis
spectrophotometry,
TEM-EDX,
XRD
analysis.
specific
interaction
RBD
immunoglobulin
G
(IgG)
antibodies
evaluated
differential
pulse
voltammetry
electrochemical
impedance
spectroscopy
in
[Fe(CN)6]4–/3–
solution
redox
system.
IgG
detected
limit
0.0561
pg
mL–1,
had
selectivity
stability
103–122%
stable
until
week
7
influence
storage
conditions.
Also,
tested
real
samples
from
human
serum,
where
results
were
confirmed
chemiluminescent
microparticle
immunoassay
(CMIA)
showed
satisfactory
results.
Therefore,
developed
can
rapidly
accurately
detect
antibodies.
Language: Английский
Nanoscale Materials in Biomedical Applications of Sensors: Insights from a Comprehensive Landscape Analysis
ACS Applied Nano Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Since
their
inception
in
the
early
1960s,
use
of
nanoscale
materials
has
progressed
leaps
and
bounds,
role
diverse
fields
ranging
from
human
health
to
energy
is
undeniable.
Nanosensors
are
devices
having
dimensions
designed
detect,
record,
transmit
signals
provide
valuable
data
information.
In
this
review,
we
utilize
CAS
Content
Collection,
a
vast
repository
scientific
information
extracted
journals
patent
publications,
identify
emerging
applications
field.
This
involves
understanding
trends,
such
as
growth
certain
topics
over
time,
well
establishing
relationships
between
topics.
Our
analysis
indicates
that
among
various
nanomorphologies
explored
nanosensors,
nanoparticles,
nanotubes,
quantum
dots
tend
lead.
terms
types
chemical
biological
sensors
account
for
nearly
80%
publications.
combination
with
bibliographic
data,
utilized
our
access
Registry
identified
host
across
substance
classes
(polymers,
small
molecules,
elements)
associated
nanosensor
Finally,
major
application
nanosensors
appears
be
biomedical
nature
(cancer
diagnosis/testing
drug
discovery,
example).
findings
highlighted
TrendScape
map
provides
an
overview
research
interest
concepts
We
also
snapshot
commercial
development
briefly
discuss
currently
under
development.
It
hope
review
comprehensive
field
serves
guide
researchers/scientists.
Language: Английский
Impedimetric Biosensor of Silver Molybdate Anchored on rGO Sheet for Detection of Breast Cancer Mucin‐1 Biomarker
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(37)
Published: Sept. 30, 2024
Abstract
This
work
aims
to
detect
the
Mucin‐1
(MUC1)
breast
cancer
biomarker
using
a
label‐free
impedimetric
biosensor
of
silver
molybdate
anchored
on
reduced
graphene
oxide
(Ag
2
MoO
4
‐rGO).
A
hydrothermal
method
has
been
employed
synthesize
Ag
‐rGO
nanocomposite.
Subsequently,
they
have
studied
through
analytical
characterization
techniques
study
electrocatalytic
activity,
electroactive
surface
area,
functionalities,
and
morphologies
determine
suitability
material
for
fabrication.
Results
reveal
that
nanocomposite
possesses
excellent
electroconductivity
properties
significant
characteristics
biosensor's
performance.
fabricated
by
immobilization
anti‐MUC1
antibody
glassy
carbon
electrode.
The
electroanalytical
studies
revealed
sensitivity
detection
performance
having
wide
linearity
100
fg
mL
−1
–5
ng
low
limit
2.70
.
Moreover,
remarkable
selectivity,
reproducibility,
stability,
in
serum
samples
high
biosensor.
Therefore,
presented
could
be
promising
diagnostic
tool
shows
potential
efficiently
MUC1
patient's
samples.
Language: Английский