Lipid Nanoparticle-Mediated Delivery of Microrna-124 Reduces Neuroinflammation

Published: Jan. 1, 2025

Language: Английский

Nano-scaffold containing functional motif of stromal cell-derived factor 1 enhances neural stem cell behavior and synaptogenesis in traumatic brain injury

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide, presenting significant challenge due to the lack effective therapies. Neural stem cells (NSCs) have shown promising potential in preclinical studies as therapy for TBI. However, their application limited by challenges related poor survival integration within injured brain. This study investigated effect novel nano-scaffold containing stromal cell-derived factor 1 (SDF-1) on NSC behavior synaptogenesis after Using an innovative design, we successfully fabricated with Young's modulus approximately 3.21 kPa, which aligns closely mechanical properties exhibited neural tissue. achievement marks first time such scaffold has been created implications its use tissue engineering applications. Our findings demonstrate that enhances proliferation, migration, differentiation capacity vitro. Moreover, when transplanted into brain, promotes NSCs, increased functional recovery. These suggest using SDF-1 could provide approach treating TBI improving promoting synaptogenesis.

Language: Английский

Emerging Insights into Brain Inflammation: Stem-Cell-Based Approaches for Regenerative Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3275 - 3275

Published: April 1, 2025

Neuroinflammation is a complex immune response triggered by brain injury or pathological stimuli, and highly exacerbated in neurodegenerative diseases. It plays dual role the central nervous system, promoting repair acute stages while aggravating disease progression contributing to neuronal loss, synaptic dysfunction, glial dysregulation chronic phases. Inflammatory responses are mainly orchestrated microglia infiltrated monocytes, which, when dysregulated, not only harm existing neurons, but also impair survival differentiation of neural stem progenitor cells affected regions. Modulating neuroinflammation crucial for harnessing its protective functions minimizing detrimental effects. Current therapeutic strategies focus on fine-tuning inflammatory through pharmacological agents, bioactive molecules, cell-based therapies. These approaches aim restore homeostasis, support neuroprotection, promote regeneration various neurological disorders. However, animal models sometimes fail reproduce human-specific brain. In this context, stem-cell-derived provide powerful tool study neuroinflammatory mechanisms patient-specific physiologically relevant context. facilitate high-throughput screening, personalized medicine, development targeted therapies addressing limitations traditional models, paving way more effective treatments.

Language: Английский