Journal of Porous Materials, Journal Year: 2024, Volume and Issue: 31(6), P. 2165 - 2175
Published: July 30, 2024
Language: Английский
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 703, P. 135227 - 135227
Published: Aug. 30, 2024
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139244 - 139244
Published: Jan. 1, 2025
Language: Английский
Citations
1
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 25, 2025
Diabetes is a growing global health issue, with millions of people affected by the condition. While insulin therapy vital for managing both Type 1 and 2 diabetes, traditional methods such as subcutaneous injections have notable drawbacks, including pain, discomfort, difficulty in maintaining stable blood sugar levels. To improve delivery, research increasingly focused on use natural polymers—substances derived from plants, animals, microorganisms. These polymers, materials like alginate, chitosan, hyaluronic acid, promising properties biocompatibility, biodegradability, ability to provide controlled, sustained release. By encapsulating it protected degradation released manner that more closely mirrors body’s production. Furthermore, development non-invasive delivery methods, oral transdermal systems, gaining momentum, offering potential patient-friendly treatment options. This review discusses role polymers examining their mechanisms, types, current efforts. It also addresses challenges remain advancing these technologies into practical clinical use, aiming efficient, comfortable, effective solutions diabetes management.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125552 - 125552
Published: April 1, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1220 - 1220
Published: Sept. 17, 2024
The assessment of ricinoleic acid (RA) incorporated into polymeric nanoparticles is a challenge that has not yet been explored. This bioactive compound, the main component castor oil, attracted attention in pharmaceutical field for its valuable anti-inflammatory, antifungal, and antimicrobial properties. work aims to develop new simple analytical method using high-performance liquid chromatography with diode-array detection (HPLC-DAD) identification quantification acid, potential applicability several other complex systems. was validated through parameters, such as linearity, limit quantification, accuracy, precision, selectivity, robustness. physicochemical properties nanocapsules were characterized by dynamic light scattering (DLS) determine their hydrodynamic mean diameter, polydispersity index (PDI), zeta (ZP), via transmission electron microscopy (TEM) quantifying encapsulation efficiency. proposed utilized mobile phase consisting 65:35 ratio acetonitrile water, acidified 1.5% phosphoric acid. It successfully depicted symmetric peak (retention time 7.5 min) both standard RA present nanoparticles, enabling drug loaded nanocapsules. containing exhibited an approximate size ranging from 309 nm 441 nm, PDI lower than 0.2, ζ values approximately -30 mV, high efficiency (~99%). Overall, developed HPLC-DAD procedure provides adequate confidence PLGA matrices.
Language: Английский
Citations
1
Journal of Porous Materials, Journal Year: 2024, Volume and Issue: 31(6), P. 2165 - 2175
Published: July 30, 2024
Language: Английский
Citations
1