Advances in Natural Sciences Nanoscience and Nanotechnology,
Journal Year:
2024,
Volume and Issue:
16(1), P. 015009 - 015009
Published: Dec. 31, 2024
Abstract
Luminescent
bacteria,
having
reductase
enzymes,
can
reduce
metal
ions
as
nanoparticles.
In
this
study,
the
synergic
effect
of
biosynthesized
selenium
nanoparticles
(SeNPs),
using
Pseudomonas
putida
KT2440,
carrying
lux
AB
gene
with
biogenic
gold
(AuNPs)
is
assessed.
The
SeNPs
were
first
purified
and
then
characterized
different
techniques,
including
UV-visible
Fourier
Transform
Infrared
(FTIR)
spectroscopy,
Transmission
Electron
Microscopy
(TEM),
Scanning
(SEM),
Energy
Dispersive
x-ray
(EDX)
spectroscopy
analyses.
antibacterial
antibiofilm
activities
also
evaluated
without
AuNPs,
at
12.5,
25,
50,
100
mg
l
−1
concentrations.
SEM
images
showed
that
spherical
attached
to
surface
producing
bacteria.
FTIR
spectroscopic
results
revealed
presence
protein
molecules
on
synthesized
SeNPs.
It
found
have
proper
against
several
potential
human
pathogenic
depending
NPs
was
AuNPs
enhances
activity
Our
adding
improved
Bacillus
subtilis
(71%),
Staphylococcus
aureus
(55%),
epidermidis
(52%),
Escherichia
coli
(47%),
aeruginosa
(26%).
Also,
by
about
26%
37%
E.
faecalis
S.
,
respectively.
conclusion,
mixture
luminescent
bacteria
Se-Au
more
effective
be
applied
an
antimicrobial
agent
multi-antibiotic
resistant
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 203 - 203
Published: Feb. 10, 2025
The
interplay
between
oxidative
stress
and
adipogenesis
is
a
critical
factor
in
the
development
of
obesity
its
associated
metabolic
disorders.
Excessive
reactive
oxygen
species
(ROS)
disrupt
key
transcription
factors
such
as
peroxisome
proliferator-activated
receptor
gamma
(PPARγ)
CCAAT/enhancer-binding
protein
alpha
(C/EBPα),
impairing
lipid
metabolism,
promoting
adipocyte
dysfunction,
exacerbating
inflammation
insulin
resistance.
Antioxidants,
classified
endogenous
(e.g.,
glutathione,
superoxide
dismutase,
catalase)
exogenous
polyphenols,
flavonoids,
vitamins
C
E),
are
pivotal
mitigating
these
effects
by
restoring
redox
balance
preserving
functionality.
Endogenous
antioxidants
neutralize
ROS
safeguard
cellular
structures;
however,
under
heightened
stress,
defenses
often
insufficient,
necessitating
dietary
supplementation.
Exogenous
derived
from
plant-based
sources,
polyphenols
vitamins,
act
through
direct
scavenging,
upregulation
antioxidant
enzymes,
modulation
signaling
pathways
like
nuclear
kappa
B
(NF-κB)
PPARγ,
reducing
peroxidation,
inflammation,
dysfunction.
Furthermore,
they
influence
epigenetic
regulation
transcriptional
networks
to
restore
differentiation
limit
accumulation.
Antioxidant-rich
diets,
including
Mediterranean
diet,
strongly
with
improved
health,
reduced
rates,
enhanced
sensitivity.
Advances
personalized
therapies,
guided
biomarkers
supported
novel
delivery
systems,
present
promising
avenues
for
optimizing
therapeutic
interventions.
This
review,
"Crosstalk
Between
Antioxidants
Adipogenesis:
Mechanistic
Pathways
Their
Role
Metabolic
Health",
highlights
mechanistic
which
regulate
enhance
health.
Zeitschrift für Naturforschung C,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Abstract
Biogenic
selenium
nanoparticles
(SeNPs)
have
emerged
as
promising
area
of
research
due
to
their
unique
properties
and
potential
multifaceted
applications.
The
biosynthesis
SeNPs
through
biological
methods,
such
using
microorganism,
plant
extracts,
etc.,
offers
a
safe,
eco-friendly,
biocompatible
approach,
compared
traditional
chemical
synthesis.
Recent
several
studies
demonstrated
that
application
includes
broad
antibacterial,
anticancer,
antioxidant,
antiviral,
anti-inflammatory,
antidiabetic,
excellent
wound
healing
activity.
On
the
other
hand,
also
shown
in
sensing
inorganic
toxic
metals,
electrochemistry,
agro-industries,
aqua-cultures,
fabrication
solar
panels.
Additionally,
capability
enhance
efficacy
antibiotics
act
effective
agents
against
multidrug-resistant
pathogens
has
addressing
critical
health
challenges.
Although,
exhibit
wide
applicability,
toxicity
Se,
particularly
its
various
oxidative
states,
necessitates
careful
assessment
environmental
impacts
associated
with
use.
Therefore,
understanding
balance
between
beneficial
risks
is
crucial
for
safe
This
review
focuses
exclusively
on
synthesized
via
eco-friendly
process,
excluding
utilizing
synthesis
processes.
Moreover,
this
aims
offer
an
overview
diverse
applications,
risks,
stability
requirement,
cytocompatibility
opportunities
SeNPs.
Ultimately,
bridges
gap
knowledge
by
providing
updated
details
applications
Biomedical & Pharmacology Journal,
Journal Year:
2025,
Volume and Issue:
18(1), P. 909 - 919
Published: March 31, 2025
Studies
on
the
functional
characteristics
of
Se
nanoparticles
(SeNP)
have
become
increasingly
popular
in
recent
decades
because
their
strong
selectivity,
stability,
and
high
biocompatibility.
Numerous
studies
demonstrate
SeNP's
anticarcinogenic
properties.
In
order
to
defeat
bacteria
that
are
resistant
antibiotics,
new
strategies
need
be
developed.
A
subclass
antimicrobial
peptides
known
as
selenium
(NPs)
can
used
either
place
or
addition
well-known
antibiotics.
SeNPs
been
investigated
with
Fourier
transform
infrared
spectroscopy
(FTIR),
X-ray
diffraction
(XRD),
zeta
potential,
transmission
electron
microscopy
(TEM).,
UV-visible
analysis.
The
antibacterial
qualities
were
confirmed
by
generated
showed
increased
activity
at
different
concertation
(1000-64)
µg/ml
good
diffusion
assay,
NPs
efficiently
suppressed
growth
susceptible
zones
inhibition
between
5-19
mm
against
Gram-Negative
while
Gram
Positive
Staphylococcus
epidermidis
aureus
6-17
,
respectively.
Our
study
has
shown
combining
various
antimicrobials
mechanisms
action
led
an
extensive
variety
raised
efficacy,
particularly
germs
several
medications.
best
anti-
human
breast
cancer
cell
line
MCF7
properties
nanocomposite
above
lines
was
case
line.
According
findings,
may
administrated
for
treatment
types
humans.
Ovarian
had
nanoparticle
sensitivity.
At
a
concentration
25
μL/mL,
demonstrated
excellent
cytotoxicity
anticancer
activity,
making
them
suitable
use
agent.The
physicochemical
characteristics,
experimental
setup,
concentrations
exploited
this
must
all
carefully
stated.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 21, 2025
Abstract
White
mustard
(
Sinapis
alba
L.)
seeds
are
the
most
commonly
used
species
in
herbal
medicine
to
treat
a
wide
range
of
inflammatory
disorders.
Due
its
increased
bioavailability
and
lower
toxicity,
green
biosynthesis
metal
nanoparticles
(M-NPs)
utilizing
plant
extract
as
capping
agent
has
been
demonstrated
over
number
years.
Thus,
current
study
sought
examine
vitro
biological
activity
copper
oxide
(CuO-NPs)
selenium
(Se-NPs)
that
were
biosynthesized
using
aqueous,
methanolic,
petroleum
ether
extracts
from
S.
seeds.
Phytochemical
activities
(antioxidant,
scavenging,
anti-diabetic,
anti-acetylcholinesterase,
anti-arthritic,
anti-inflammatory,
cytotoxic
activities)
assayed
all
prepared
before
after
being
for
M-NPs.
It
was
found
total
methanolic
possessed
highest
compared
other
native
extracts.
The
LC-ESI-MS/MS
analysis
secondary
metabolites
showed
contained
7
phenolic
acids
9
flavonoid
aglycones.
This
helped
find
active
ingredients.
We
characterized
8
acid
derivatives,
glycosides,
4
aliphatic
glucosinolates,
3
aromatic
aryl
glucosinolates
aqueous
extract.
Furthermore,
contains
concentrations
polyphenols,
condensed
tannins,
compounds.
Se-NPs
higher
those
CuO-NPs.
median
lethal
dose
(LD
50
)
studied
appeared
safer
findings
this
concluded
is
suitable
bioresource
biosynthesizing
through
nanotechnology,
with
efficiency
relation
metabolite
fingerprint.
Microscopy Research and Technique,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Selenium
nanoparticles
(SeNPs)
have
garnered
significant
interest
as
anticancer
and
antimicrobial
agents.
The
aqueous
extract
of
medicinal
plant
Drimia
indica
leaves
(DI-LAE)
was
used
to
synthesize
SeNPs
(DI-SeNPs)
that
were
extensively
characterized
by
UV-visible
absorbance,
TEM,
EDX,
XRD,
zeta
potential
measurements,
FTIR.
DI-SeNPs
exhibited
dose-dependent
toxicity
against
the
human
lung
adenocarcinoma
cell
line
(A549;
IC
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(11)
Published: June 1, 2024
Chemotherapy
resistance
remains
a
significant
challenge
in
treating
ovarian
cancer
effectively.
This
study
addresses
this
issue
by
utilizing
dual
drug-loaded
nanomicelle
system
comprising
albendazole
(ABZ)
and
paclitaxel
(PTX),
encapsulated
novel
carrier
matrix
of
D-tocopheryl
polyethylene
glycol
1000
succinate
vitamin
E
(TPGS),
soluplus
folic
acid.
Our
objective
was
to
develop
optimize
nanoparticulate
delivery
using
solvent
evaporation
techniques
enhance
the
therapeutic
efficacy
against
cancer.
The
formulation
process
involved
pre-formulation,
formulation,
optimization,
comprehensive
characterization
micelles.
Optimization
conducted
through
32
factorial
design,
focusing
on
effects
polymer
ratios
particle
size,
zeta
potential,
polydispersity
index
(PDI)
entrapment
efficiency
(%EE).
optimal
demonstrated
improved
dilution
stability,
as
indicated
critical
micelle
concentration
(CMC)
0.0015
mg/mL
for
TPGS-folic
acid
conjugate
(TPGS-FOL).
Extensive
included
differential
scanning
calorimetry
(DSC),
nuclear
magnetic
resonance
(NMR),
Fourier-transform
infrared
spectroscopy
(FTIR).
release
profile
exhibited
an
initial
burst
followed
sustained
over
90
h.
cytotoxic
potential
formulated
micelles
superior
that
drugs
alone,
assessed
MTT
assays
SKOV3
cell
lines.
Additionally,
vivo
studies
confirmed
presence
both
plasma
tumour
tissues,
suggesting
effective
targeting
penetration.
In
conclusion,
developed
TPGS-Fol-based
nanomicelles
co-delivering
ABZ
PTX
show
promising
results
overcoming
drug
resistance,
enhancing
solubility,
sustaining
release,
improving
outcomes
treatment.
Materials,
Journal Year:
2024,
Volume and Issue:
17(15), P. 3748 - 3748
Published: July 29, 2024
In
recent
years,
selenium
nanoparticles
(SeNPs)
have
attracted
expanding
consideration,
particularly
in
the
nanotechnology
field.
This
element
participates
important
biological
processes,
such
as
antioxidant
defense,
immune
function,
and
thyroid
hormone
regulation,
protecting
cells
from
oxidative
damage.
Selenium
form
of
nanoscale
particles
has
drawn
attention
for
its
biocompatibility,
bioavailability,
low
toxicity;
thus,
it
found
several
biomedical
applications
diagnosis,
treatment,
monitoring.
Green
methods
SeNP
synthesis
using
plant
extracts
are
considered
to
be
single-step,
inexpensive,
eco-friendly
processes.
Besides
acting
natural
reductants,
compounds
can
also
serve
capping
agents,
stabilizing
size
contributing
enhanced
properties
SeNPs.
brief
overview
presents
developments
this
area,
focusing
on
conditions
characteristics
obtained
