The anti‐Acinetobacter baumannii therapeutic potential of azole hybrids: A mini‐review

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Acinetobacter baumannii is one of the major causes severe hospital- and community-acquired infections, posing a significant threat to human lives. A. has already generated resistance almost all currently available antibiotics, but no new class antibacterials have been launched for treatment infections caused by in last half century, creating an urgent need develop novel antibacterials. Azoles as broad five-membered nitrogen-containing aromatic heterocycles are privileged pharmacophores widely found pharmaceuticals. could target on diverse enzymes, proteins, receptors via various noncovalent interactions. Particularly, azole hybrids potential advantages increasing therapeutic efficacy circumventing drug resistance, representing useful scaffolds discovery anti-A. agents. This review outlines current scenario antibacterial against baumannii, developed from 2020 onwards, aiming provide candidates further preclinical/clinical evaluations facilitate rational design more effective candidates.

Language: Английский

Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families.

Antiviral Research, Journal Year: 2024, Volume and Issue: 231, P. 106003 - 106003

Published: Sept. 10, 2024

Language: Английский