Preparation and Characterization of Injectable Augmentation Gels Containing Polycaprolactone and Hyaluronic Acid DOI Creative Commons

Meryem Erken Turkmen,

Mohammadreza Ghaffarlou, Busra Kilic

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

ABSTRACT Background Injectable augmentation gels are widely used in the treatment of soft tissue. The composition these has to be continuously improved due limitations currently available formulations. Aims This study focuses on development an innovative injectable gel designed address current trends and specific needs within field. Methods utilized a safer hyaluronic acid (HA) carrier, created with less toxic cross‐linker, combination polycaprolactone (PCL) microspheres at various concentrations. PCL were prepared using emulsification‐solvent evaporation technique. Six different formulations developed biphasic HA structures. Results produced had non‐agglomerated, smooth surfaces average particle size approximately 45 ± 0.14 μm. rheological results PCL‐HA6 such as storage modulus ( G ', Pa), loss ", complex viscosity η *), phase angle (°) 1 Hz frequency measured 553.97 32.48, 368.4 12.24, 105.9 5.27, 33.65 0.92, respectively, injection force was 9.64 1.46. In vitro tests revealed that group showed highest cell viability compared other groups provided relative increase collagen production over time, demonstrated by relevant gene expression. Conclusions PCL/HA exhibited biocompatibility non‐toxicity, making it safe option for tissue augmentation. It potential medical applications favorable characteristics injectability.

Language: Английский

Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles DOI Creative Commons

Hanjing Li,

Yining Liu, Yuqing Lin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 3, 2025

Language: Английский

Citations

5
Konjac glucomannan-based composite materials: Construction, biomedical applications, and prospects DOI

K. Zhuang,

Xin Shu,

Wenjing Xie

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 344, P. 122503 - 122503

Published: July 19, 2024

Language: Английский

Citations

10
Breaking barriers in cancer management: The promising role of microsphere conjugates in cancer diagnosis and therapy DOI Creative Commons
Ashutosh Gupta, Sanjay Kulkarni, Soji Soman

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 665, P. 124687 - 124687

Published: Sept. 10, 2024

Language: Английский

Citations

10
Alginate Beads with Encapsulated Date Palm Pollen Extract: Development, Characterization and Their Potential Role in Hepato-Protection and Fertility-Stimulating Hormones Improvement in Bisphenol A-Treated Rats DOI Open Access
Karem Fouda, Rasha S. Mohamed

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 912 - 912

Published: March 28, 2025

The goal of this study was to design polymeric beads with a core date palm pollen (DPP, Phoenix dactylifera L.) extract using the ionic gelation method and then assess effects in combination alginate polymer (alginate/DPP beads) on profile phenolic compounds, their vitro controlled release, as well antioxidant characteristics, potential role hepato-protection fertility-stimulating hormones improvement bisphenol A (BPA)-treated rats. encapsulation efficiency (EE) 94.27 ± 1.47%. found that release highest (89.81%) at pH 7.4 (simulated intestinal fluid) lowest (59.43%) 2 stomach after 3 h. This particular type bead also exhibited significant activity, component content, flavonoid content. estimated content 66.48 mg GAE/g, methyl gallate, gallic acid, naringenin main components. In vivo evaluation findings revealed both doses alginate/DPP (delivering 250 350 mg/kg per day) significantly protected liver (as demonstrated by downregulated function parameters), improved levels male hormones, reduced oxidative stress parameters inflammatory cytokines, testicular tissues from BPA-induced changes. Thus, actions make them promising choice for antioxidant, liver-protecting, hormone-enhancing hydrogels.

Language: Английский

Citations

1
Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration DOI Creative Commons
Nimeet Desai, Shreya Pande, Lalitkumar K. Vora

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4270 - 4292

Published: July 1, 2024

Bone, a fundamental constituent of the human body, is vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present promising platform regeneration by mimicking native extracellular matrix architecture. Through optimized fabrication techniques incorporation active biomolecular components, NFMS precisely replicate nanostructure biochemical cues essential osteogenesis promotion. Furthermore, exhibit versatile properties, including tunable morphology, mechanical strength, controlled release kinetics, augmenting their suitability tailored engineering applications. enhance cell recruitment, attachment, proliferation, while promoting osteogenic differentiation mineralization, thereby accelerating healing. This review highlights engineering, elucidating design principles key attributes. By examining recent preclinical applications, we assess current clinical status discuss critical considerations potential translation. offers crucial insights researchers at intersection biomaterials highlighting developments this expanding field.

Language: Английский

Citations

5
Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering DOI Creative Commons
Yifan Wang, Chuyue Zhang,

Junyao Cheng

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 979 - 979

Published: July 24, 2024

Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, former falls short in halting IVDD progression, while latter carries inherent risks. Hence, quest for an efficacious method reverse onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, microneedles, renowned their exceptional biocompatibility, biodegradability, biological efficacy, mechanical attributes, have found widespread application bone, cartilage, various tissue engineering endeavors. Consequently, IVD has emerged burgeoning field of interest. This paper succinctly introduces intervertebral (IVD) structure pathophysiology IVDD, meticulously classifies biomaterials repair, reviews recent advances field. Particularly, strengths weaknesses are emphasized, potential avenues future research suggested.

Language: Английский

Citations

4
“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems” DOI
Sudharshan Reddy Dachani, Ankur Vashi, Anand B. Mundada

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.

Language: Английский

Citations

4
One-step and one-pot synthesis of wrinkled polymer microspheres based on monomer reactivity ratio difference DOI
Tian Liu,

Yungui Ma,

Deng‐Guang Yu

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113707 - 113707

Published: Jan. 1, 2025

Language: Английский

Citations

0
Xanthium‐Inspired Microsphere Morphology Depends on the Dual Self‐Assembly Behavior of Macromolecules DOI Open Access

Luyao Xing,

Jiaqiang Ding,

Jiaqi Gao

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The self-assembly of macromolecular segments promotes the fabrication polymer microspheres with multiple morphologies. Inspired by xanthium shells, A dual-driven method have defined that enables construction multi-dimensional morphologies on microsphere surface at emulsion-confined interfaces. two driving forces are derived from phase separation caused immiscibility and different interactions between chain hydrophilicity water molecules. synergistic effects these forces, shell structure is constructed surface, enabling development increasingly complex superstructure. This scalable approach provides extensive potential for technology block copolymers opposite properties.

Language: Английский

Citations

0
Preparation of Colored Polymer Microspheres DOI Creative Commons
Lei Wang, Weiting Ma,

Shuheng Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 375 - 375

Published: Jan. 17, 2025

Colored polymer microspheres have attracted significant attention in both academia and industry due to their unique optical properties extensive application potential. However, achieving a uniform distribution of dyes within these remains challenge, particularly when heavy concentrations dye are used, as this can lead aggregation or delamination, adversely affecting application. Additionally, many prone degradation fading exposed light, heat, chemicals, which compromises the long-term color stability microspheres. Consequently, preparation colored with high continues be challenge. This review offers comprehensive overview techniques for dyeing mechanisms, introducing fundamental concepts applications various fields, such biomedicine, devices, electronic display technologies. It further presents detailed discussion different methods, including physical adsorption, chemical bonding, copolymerization. The advantages, limitations, potential improvements each method explored, along an analysis interactions between matrix, how influence microspheres, uniformity, stability, durability. Finally, discusses future perspectives on development highlighting advancement novel materials, innovations technology, exploration new areas.

Language: Английский

Citations

0