The RAGE Inhibitor TTP488 (Azeliragon) Demonstrates Anti-Tumor Activity and Enhances the Efficacy of Radiation Therapy in Pancreatic Cancer Cell Lines DOI Open Access
Kumari Alka, Jacob F. Oyeniyi, Ghulam Mohammad

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 17 - 17

Published: Dec. 24, 2024

Pancreatic cancer is the third leading cause of cancer-related mortality in United States, with rising incidence and mortality. The receptor for advanced glycation end products (RAGE) its ligands significantly contribute to pancreatic progression by enhancing cell proliferation, fostering treatment resistance, promoting a pro-tumor microenvironment via activation nuclear factor-kappa B (NF-κB) signaling pathways. This study validated pathway human evaluated therapeutic efficacy TTP488 (Azeliragon), small-molecule RAGE inhibitor, alone combination radiation therapy (RT) preclinical models cancer. Human (Panc1) murine (Pan02) lines exhibited elevated levels compared normal tissue. In vitro, Azeliragon inhibited RAGE-mediated NF-κB ligand-mediated proliferation lines. Target engagement was confirmed vivo, as determined decreased activation. demonstrated significant growth delay mouse additive effects when combined RT. Additionally, modulated immune suppressive tumor reducing immunosuppressive cells, including M2 macrophages, regulatory T myeloid-derived suppressor while CD8+ infiltration. These findings suggest that Azeliragon, inhibiting modulating response, may serve an effective anti-cancer agent

Language: Английский

Modulation of PRC1 Promotes Anticancer Effects in Pancreatic Cancer DOI Open Access
Hajin Lee,

An-Na Bae,

Huiseong Yang

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3310 - 3310

Published: Sept. 27, 2024

Background: Pancreatic cancer, while relatively uncommon, is extrapolated to become the second leading cause of cancer-related deaths worldwide. Despite identifying well-known markers like KRAS gene, exact regulation pancreatic cancer progression remains elusive. Methods: Clinical value PRC1 was analyzed using bioinformatics database. The role further evaluated through cell-based assays, including viability, wound healing, and sensitivity with drug. Results: We demonstrate that significantly overexpressed in compared pancreases without as revealed human databases cell lines analysis. Furthermore, high expression had a negative correlation CD4+ T cells, which are crucial for immune response against cancers. Additionally, showed positive established markers. Silencing siRNA inhibited proliferation viability increased chemotherapeutic drug sensitivity. Conclusions: These findings suggest targeting may enhance infiltration inhibit proliferation, offering promising avenue developing anticancer therapies.

Language: Английский

Citations

2
Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal Adenocarcinoma DOI Open Access
Risky Oktriani, Anna Chiara Pirona, Lajos Kalmár

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3684 - 3684

Published: Oct. 31, 2024

: Early and aggressive metastasis is a major feature of pancreatic ductal adenocarcinoma. Understanding the processes underlying crucial for making difference to disease outcome. Towards these ends, we looked in comprehensive manner genes that are metastasis-specific.

Language: Английский

Citations

2
A 3D Bio-Printed-Based Model for Pancreatic Ductal Adenocarcinoma DOI Creative Commons

Claire Godier,

Zakaria Baka,

Laureline Lamy

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 206 - 206

Published: Sept. 10, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis, characterized by incidence rates close to death rates. Despite the efforts of scientific community, preclinical models that faithfully recreate PDAC tumor microenvironment remain limited. Currently, use 3D bio-printing an emerging and promising method for development cancer reproducible heterogeneity precisely controlled structure. This study presents model using extrusion technique. Initially, combining pancreatic cells (Panc-1) cancer-associated fibroblasts (CAFs) encapsulated in sodium alginate gelatin-based hydrogel mimic metastatic stage was developed comprehensively characterized. Subsequently, were made vascularize this model. demonstrates resulting tumors can maintain viability proliferate, self-organizing into aggregates heterogeneous composition. The utilization creating opens avenues reproducing complexity future, offering versatile platform improving anti-cancer therapy models.

Language: Английский

Citations

1
Advances in Endoscopic Ultrasound in Pancreatic Cancer Screening, Diagnosis, and Palliative Care DOI Creative Commons

Wenyu Zhang,

Jingzheng Chen,

Wei Zhang

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 76 - 76

Published: Dec. 31, 2024

Pancreatic cancer is a highly aggressive malignancy with profoundly poor prognosis. Clinically, the condition most frequently manifests symptoms including painless jaundice, abdominal discomfort, and back pain. Early diagnosis implementation of effective therapeutic strategies are critical for improving patient survival outcomes. However, merely 10–20% patients diagnosed at an early stage, majority presenting advanced stages, often metastasis. Consequently, detection intervention crucial enhancing The widespread adoption endoscopic ultrasonography (EUS) technology in recent years has significantly enhanced diagnostic accuracy pancreatic space-occupying lesions. EUS increasingly recognized its pivotal role alleviating malignant biliary obstruction (MBO), gastric outlet (GOO), refractory pain cancer. This article aims to provide overall review current applications treatment cancer, exploring advantages limitations screening, diagnosis, palliative care. Furthermore, this explores potential future directions field, aiming valuable insights inform enhance clinical management

Language: Английский

Citations

1
How Does Cancer Occur? How Should It Be Treated? Treatment from the Perspective of Alkalization Therapy Based on Science-Based Medicine DOI Creative Commons
Reo Hamaguchi, Masahide Isowa,

Ryoko Narui

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2197 - 2197

Published: Sept. 26, 2024

This review article investigates the relationship between mitochondrial dysfunction and cancer progression, emphasizing metabolic shifts that promote tumor growth. Mitochondria are crucial for cellular energy production, but they also play a significant role in progression by promoting glycolysis even under oxygen-rich conditions, phenomenon known as Warburg effect. reprogramming enables cells to maintain an alkaline internal pH acidic external environment, which critical their proliferation survival hypoxic conditions. The explores microenvironment (TME), consequence of intensive glycolytic activity proton production cells. milieu enhances invasiveness metastatic potential contributes increased resistance chemotherapy. Alkalization therapy, involves neutralizing this acidity through dietary modifications administration alkalizing agents such sodium bicarbonate, is highlighted effective strategy counteract these adverse conditions impede progression. Integrating insights from science-based medicine, evaluates effectiveness alkalization therapy across various types clinical assessments. Science-based utilizes inductive reasoning observed outcomes, lends support hypothesis treatment. By addressing both environmental disruptions, suggests considering primarily disorder could lead more targeted treatment strategies, potentially improving outcomes patients with advanced-stage cancers.

Language: Английский

Citations

0
Pancreatic Metastases of Esophageal Squamous Cell Carcinoma: A Case Report and Review of the Literature DOI Creative Commons
Tivadar Bara,

Alexandra Georgiana Scurtu,

T Bara

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(19), P. 2164 - 2164

Published: Sept. 28, 2024

Esophageal carcinoma is an aggressive cancer with a poor therapeutic response and significant risk of recurrence after radical resection. It usually metastasizes to the lung, bones, or liver. Unusual spread can be found in other organs, but only nine cases pancreatic metastases have been reported Medline database. In present paper, literature review esophageal squamous cell metastasis was carried out. addition these cases, we our case, tenth case literature. involved patient who underwent surgery for developed metachronous 67 months esophagectomy. Histopathological examination confirmed metastasis. Conclusions: Pancreatic extremely rare. may develop several years treatment primary lesion. The diagnosis difficult, requiring histopathological immunohistochemical examination.

Language: Английский

Citations

0
Improving postoperative outcomes in patients with pancreatic cancer: Inflammatory and nutritional biomarkers DOI
Chun‐Han Cheng, Wen‐Rui Hao,

Tzu-Hurng Cheng

et al.

World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 30, 2024

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic cancer. Lu et al evaluated ability seven to predict postoperative recovery long-term outcomes. These were albumin-to-globulin ratio, index (PNI), systemic immune-inflammation index, neutrophil-to-lymphocyte platelet-to-lymphocyte risk geriatric index. The PNI was found be a strong predictor both overall recurrence-free survival, underscoring its clinical relevance managing with

Language: Английский

Citations

0
Smad4 Heterozygous Knockout Effect on Pancreatic and Body Weight in F1 Population Using Collaborative Cross Lines DOI Creative Commons
Osayd Zohud, Iqbal M. Lone, Kareem Midlej

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 918 - 918

Published: Nov. 12, 2024

, a critical tumor suppressor gene, plays significant role in pancreatic biology and tumorigenesis. Genetic background sex are known to influence phenotypic outcomes, but their impact on weight

Language: Английский

Citations

0
Sirtuins as Key Regulators in Pancreatic Cancer: Insights into Signaling Mechanisms and Therapeutic Implications DOI Open Access
Surbhi Chouhan, Anil Kumar, Naoshad Muhammad

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 4095 - 4095

Published: Dec. 6, 2024

Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by rapid progression, pronounced chemoresistance, and a complex network genetic epigenetic dysregulation. Within this challenging context, sirtuins, NAD

Language: Английский

Citations

0
Pancreatectomy with Celiac Axis Resection and Reconstruction for Locally Advanced Pancreatic Cancer DOI Open Access
Satoshi Mizutani,

Nobuhiko Taniai,

Makoto Sukegawa

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 4115 - 4115

Published: Dec. 8, 2024

With the advent of effective chemotherapy, conversion surgery (CS) has been performed in patients who have responded to pretreatment, even for pancreatic cancer diagnosed as unresectable (UR) at time initial diagnosis. In CS, major arterial resection and reconstruction are necessary complete radical resection.

Language: Английский

Citations

0