ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Sept. 27, 2024

Abstract Reduced graphene oxide (rGO) is a potential biomaterial for tissue engineering, photothermal therapy, and drug delivery. However, the hydrophobic nature of rGO results in poor dispersibility physiologically relevant aqueous environment, limiting its biomedical applications. To surmount this problem, here, we have developed silanized derivative reduced (rSiGO) using 3‐Aminopropyl) triethoxysilane evaluated impact on [I] stability different solvents, [ii] loading capacities, [iii] biocompatibility. The physico‐chemical characterization suggested that silanization alters 2D carbon skeleton to certain extent improves drug‐loading capacity. vitro cytocompatibility study showed rSiGO was compatible with human dermal fibroblasts murine fibroblast cell lines. It also found possesses higher capacity hydrophilic drugs than rGO. drug‐loaded cytotoxicity against hepatocarcinoma cells by inducing intracellular reactive oxygen species production, apoptosis, nuclear fragmentation. In vivo systemic toxicity studies mice nontoxic at tested concentration. These clearly dispersibility, capacity, biocompatibility making it better candidate various

Language: Английский