Ultrasound-Targeted Microbubble Destruction Enhances the Inhibitory Effect of Sonodynamic Therapy against Hepatocellular Carcinoma DOI Creative Commons

Huajing Yang,

Yunfeng Qu,

Yuhang Tian

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(52), P. 51253 - 51263

Published: Dec. 18, 2024

Purpose: To assess the anticancer effect of microbubbles (MBs) in combination with sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy (SDT) for vitro and vivo treatment hepatocellular carcinoma (HCC). Methods: HepG2 cells were used experiments. Reactive oxygen species (ROS) production was detected using 2′,7′-dichlorodihydrofluorescein diacetate singlet sensor green solution, respectively. Cytotoxicity evaluated a Cell Counting Kit 8 assay calcein AM/PI double-staining method. Annexin V-FITC/PI staining employed to analyze rate cell apoptosis. surface calreticulin exposure, high mobility group box 1 release, adenosine triphosphate secretion measured detect immunogenic death (ICD). The further assessed Hepa1–6 tumor-bearing mice. Results: Compared SDT alone, ROS MBs + enhanced 1.2-fold (p < 0.0001). cytotoxic DVDMS-mediated on concentration-dependent, additional application increased cytotoxicity. Additionally, augmented SDT-induced apoptosis from 33.26 ± 13.48 72.95 7.95% 0.01). Notably, our results demonstrated that can enhance ICD. In experiments, combined significantly reduced tumor volume, negligible differences mouse body weight. Furthermore, effectively tissue destruction. Conclusion: present study indicates markedly improve effects HCC.

Language: Английский

Current status of nanoparticle-mediated immunogenic cell death in cancer immunotherapy DOI
Tuan Hiep Tran, Thi Thu Phuong Tran

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113085 - 113085

Published: Sept. 13, 2024

Language: Английский

Citations

1
Sonodynamic Therapy for Intestinal Obstruction Caused by Intestinal Metastasis of Bladder Cancer: A Case Report DOI Creative Commons

Li Zhaoxue,

Hongtao Du,

Guoqing Shao

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 50, P. 104354 - 104354

Published: Oct. 9, 2024

This paper presents a case report of patient with intestinal obstruction caused by metastasis bladder cancer treated sonodynamic therapy. Sonodynamic therapy is novel anti-tumor that safe, effi- cacious, and has minimal side effects. After treatment, the patient's was effectively relieved.

Language: Английский

Citations

1
Ultrasonic nanotechnology for the effective management of Staphylococcus aureus skin infections: an update DOI
Naveen Thanjavur,

Anantha Lakshmi Buddolla,

Laxmi Bugude

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(35), P. 16329 - 16343

Published: Jan. 1, 2024

Ultrasonic nanotechnology is a groundbreaking, non-invasive approach for treating Staphylococcus aureus skin infections, effectively addressing antibiotic resistance and biofilm formation.

Language: Английский

Citations

0
Recent advances and future directions in sonodynamic therapy for cancer treatment DOI Creative Commons
Priyankan Datta, Sreejesh Moolayadukkam,

Dhrubajyoti Chowdhury

et al.

BME Frontiers, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Deep-tissue solid cancer treatment has a poor prognosis, resulting in very low 5-year patient survival rate. The primary challenges facing tumor therapies are accessibility, incomplete surgical removal of tissue, the resistance hypoxic and heterogeneous microenvironment to chemotherapy radiation, suffering caused by off-target toxicities. Here, sonodynamic therapy (SDT) is an evolving therapeutic approach that uses low-intensity ultrasound target deep-tissue tumors. ability deliver energy safely precisely into small (>10 cm) volumes makes SDT more effective than conventional photodynamic therapy. While currently phase 1/2 clinical trials for glioblastoma multiforme, its use other treatments, such as breast, pancreatic, liver, prostate cancer, still preclinical stage, with further investigation required improve efficacy. This review, therefore, focuses on recent advances treatments. We describe interaction between sonosensitizer molecules associated transfer mechanism malignant cells, which plays central role SDT-mediated cell death. Different sensitizers used various treatments listed, critical parameters reviewed. also discuss approaches efficacies these sonosensitizers, 3-dimensional spheroid vitro investigations, ultrasound-controlled CAR-T SDT-based multimodal therapy, machine learning optimization, could facilitate translation SDT.

Language: Английский

Citations

0
Characteristics of Ultrasound-Driven Barium Titanate Nanoparticles and the Mechanism of Action on Solid Tumors DOI Creative Commons

Shuao Li,

Ningning He, Xiao Yu Wu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12769 - 12791

Published: Nov. 1, 2024

Sonodynamic therapy (SDT) utilizes specific sound waves to activate sonosensitizers, generating localized biological effects eliminate tumor cells. With advancements in nanomedicine, the application of nano-acoustic sensitizers has significantly advanced development SDT. BaTiO3 (BTO), an inorganic sensitizer, possesses light refraction characteristics and a high dielectric constant, can generate electric field under ultrasound (US) stimulation. continuous progress multidisciplinary fields US research, scientists have developed various types barium titanate nanoparticles (BTNPs) further advance SDT research applications therapy. In this review, we present recently proposed representative BTNPs, including their pathways action, such as induction cell senescence, ferroptosis, glutathione depletion reshape microenvironment, well surface modifications. Research indicates that mechanisms action ultrasound-driven BTNPs are multifaceted. These mechanisms, whether utilized individually or synergistically, offer potent targeted strategy for cancer treatment. Furthermore, discuss types. Finally, summarize current challenges future prospects clinical translation BTNPs.

Language: Английский

Citations

0
Ultrasound-Targeted Microbubble Destruction Enhances the Inhibitory Effect of Sonodynamic Therapy against Hepatocellular Carcinoma DOI Creative Commons

Huajing Yang,

Yunfeng Qu,

Yuhang Tian

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(52), P. 51253 - 51263

Published: Dec. 18, 2024

Purpose: To assess the anticancer effect of microbubbles (MBs) in combination with sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy (SDT) for vitro and vivo treatment hepatocellular carcinoma (HCC). Methods: HepG2 cells were used experiments. Reactive oxygen species (ROS) production was detected using 2′,7′-dichlorodihydrofluorescein diacetate singlet sensor green solution, respectively. Cytotoxicity evaluated a Cell Counting Kit 8 assay calcein AM/PI double-staining method. Annexin V-FITC/PI staining employed to analyze rate cell apoptosis. surface calreticulin exposure, high mobility group box 1 release, adenosine triphosphate secretion measured detect immunogenic death (ICD). The further assessed Hepa1–6 tumor-bearing mice. Results: Compared SDT alone, ROS MBs + enhanced 1.2-fold (p < 0.0001). cytotoxic DVDMS-mediated on concentration-dependent, additional application increased cytotoxicity. Additionally, augmented SDT-induced apoptosis from 33.26 ± 13.48 72.95 7.95% 0.01). Notably, our results demonstrated that can enhance ICD. In experiments, combined significantly reduced tumor volume, negligible differences mouse body weight. Furthermore, effectively tissue destruction. Conclusion: present study indicates markedly improve effects HCC.

Language: Английский

Citations

0