ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine DOI

Zhengyang Quan,

Sa Wang,

Huanhuan Xie

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.

Language: Английский

AI-Driven Innovations in Smart Multifunctional Nanocarriers for Drug and Gene Delivery: A Mini-Review DOI

H. Noury,

Abbas Rahdar, Luiz Fernando Romanholo Ferreira

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104701 - 104701

Published: March 1, 2025

Language: Английский

Citations

1
Advances in Gene Therapy for Neurologic Disorders: An Overview DOI Creative Commons
Pallavi Chand, K. Trideva Sastri, Ashish Singh Chauhan

et al.

BIO Integration, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Neurologic disorders currently affect approximately 100 million people worldwide. most often occur due to inherent genetic mutations, which lead numerous types of functional disruptions in nervous system development. disease-related events, such as and epigenetic changes, cause inflammatory processes the area may enhance disease cycle. Gene therapy has progressed a compelling therapeutic approach for various neurodegenerative disorders. Several efforts gene rely on discovering novel vectors, recent curative targets, dependability transgenic delivery paths. These viral non-viral vectors techniques are carefully screened through preclinical clinical levels eventually render patients with effective therapies. This review addresses developments obstacles diseases discusses emerging strategies, goals, prospects.

Language: Английский

Citations

0
Unlocking the future: Precision oligonucleotide therapy for targeted treatment of neurodegenerative disorders DOI Creative Commons
Naitik Jain, Amrita Arup Roy,

Geethu Madhusoodanan

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143515 - 143515

Published: April 1, 2025

Language: Английский

Citations

0
Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders DOI Open Access
Corneliu Toader,

Călin Petru Tătaru,

Octavian Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13614 - 13614

Published: Dec. 19, 2024

Neuroimmunology is reshaping the understanding of central nervous system (CNS), revealing it as an active immune organ rather than isolated structure. This review delves into unprecedented discoveries transforming field, including emerging roles microglia, astrocytes, and blood–brain barrier (BBB) in orchestrating neuroimmune dynamics. Highlighting their dual both repair disease progression, we uncover how these elements contribute to intricate pathophysiology neurodegenerative diseases, cerebrovascular conditions, CNS tumors. Novel insights microglial priming, astrocytic cytokine networks, meningeal lymphatics challenge conventional paradigms privilege, offering fresh perspectives on mechanisms. work introduces groundbreaking therapeutic innovations, from precision immunotherapies controlled modulation BBB using nanotechnology focused ultrasound. Moreover, explore fusion with neuromodulatory technologies, underscoring new frontiers for personalized medicine previously intractable diseases. By synthesizing advancements, propose a transformative framework that integrates cutting-edge research clinical translation, charting bold path toward redefining management era neuroimmunology.

Language: Английский

Citations

1
Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation DOI Creative Commons
Dmitry I. Maltsev, Maxim A. Solotenkov,

Liana F. Mukhametshina

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Oct. 25, 2024

Thermogenetics is a promising neuromodulation technique based on the use of heat-sensitive ion channels. However, way to its clinical application, number questions have be addressed. First, avoid immune response in future human applications, channels should studied as thermogenetic actuators. Second, heating levels necessary activate these vivo brain tissue and cytotoxicity temperatures Third, possibility safety chronic has demonstrated. In this study, we present comprehensive framework for using thermosensitive channel hTRPV1. By targeting hTRPV1 expression excitatory neurons mouse activating them within non-harmful temperature range with fiber-coupled infrared laser, not only induced neuronal firing stimulated locomotion mice, but also demonstrated that thermogenetics can employed repeated without causing evident injury. Our results lay foundation research therapy neuropathologies.

Language: Английский

Citations

0
ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine DOI

Zhengyang Quan,

Sa Wang,

Huanhuan Xie

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.

Language: Английский

Citations

0