Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 317, P. 124446 - 124446
Published: May 10, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 1, 2024
Increasing bacterial infections and growing resistance to available drugs pose a serious threat human health the environment. Although antibiotics are crucial in fighting infections, their excessive use not only weakens our immune system but also contributes resistance. These negative effects have caused doctors be troubled by clinical application of antibiotics. Facing this challenge, it is urgent explore new antibacterial strategy. MXene has been extensively reported tumor therapy biosensors due its wonderful performance. Due large specific surface area, remarkable chemical stability, hydrophilicity, wide interlayer spacing, excellent adsorption reduction ability, shown potential for biopharmaceutical applications. However, there few antimicrobial evaluations on MXene. The current mechanisms mainly include physical damage, induced oxidative stress, photothermal photodynamic therapy. In paper, we reviewed MXene-based composites discussed guide further research field.
Language: Английский
Citations
27
Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 107 - 107
Published: Feb. 13, 2025
MXene is a new family of two-dimensional nanomaterials with outstanding electrical conductivity, tunable structure, biocompatibility, and large surface area. Thanks to these unique physicochemical properties, has been used for constructing electrochemical sensors (MECSens) excellent performance. In particular, the abundant termination can contribute greatly enhancing analytical sensitivity selectivity MECSens. Recently, MECSens have widely applied in many fields including clinical diagnosis, infectious disease surveillance, food security. However, not all materials are suitable building sensors. this article, we present an overview different that developed so far. We begin short summary preparation characterization Subsequently, performance, detection strategies, application scenarios classified briefly discussed. The article ends conclusion future perspectives. hope will be helpful designing activity analysis.
Language: Английский
Citations
4
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The importance of nanotechnology is increasing every day in different fields and, especially, the application nanomaterials has attracted considerable attention food safety. Among nanomaterials, MXenes, which are two-dimensional (2D) transition metal-based layered materials made nitrides and carbides, have revolutionized various as a cutting-edge scientific discovery nanotechnology. These been widely used structure biosensors sensors due to their excellent metallic conductivity, mechanical stability, optical absorbance, good redox capability, higher heterogeneous electron transfer rate. In particular, MXenes nanozymes highlighted high performance great extent biosensor domains. growing interest these attributed specific physicochemical features. key enzymatic features include activities similar oxidase, peroxidase, catalase, superoxide dismutase. this review, initially, several common synthesis methods presented, emphasizing significant role constructing efficient sensors. Subsequently, applications MXene safety analysis delved into, including detection bacteria, mycotoxins, antibiotic residues, pesticide along with electrochemical biosensors. addition, gap, limitation, future perspective novel highlighted.
Language: Английский
Citations
2
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 177, P. 117815 - 117815
Published: June 12, 2024
Language: Английский
Citations
11
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 338, P. 103404 - 103404
Published: Jan. 23, 2025
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Abstract Non‐thermal bioelectricity cancer therapy (BECT), utilizing high‐voltage and high‐frequency pulsed electric fields, represents a novel approach in oncological treatment. Herein, an pulse‐regulated MXene‐based nanozyme (MXenzyme)‐catalyzed cell eradication is presented while activating immunogenic responses for integrative BECT immunotherapy. Ti₃C₂ MXenzyme, the most conductive member of MXene family, synthesized characterized superior electrical properties aqueous environment. Incorporating MXenzyme into significantly enhances irreversible death expands ablation area compared to alone. Computational modeling reveals that on membranes generates localized hotspots current density field (E‐field) concentration during application. catalytic effect induced three primary cytotoxic mechanisms: 1) direct membrane depolarization poration, 2) disruption voltage‐gated ion channels, 3) generation reactive oxygen species. These combined mechanisms contributed death. Immunological profiling tumor microenvironment modulated by MXenzyme‐BECT confirmed its profound impact activation potent anti‐tumor immune response. Translational potential evaluated using computational modeling‐based pre‐treatment planning combination with checkpoint inhibitor therapy. Findings underscore MXenzyme's pivotal role as highly electric‐regulated enzymatic catalyst, enhancing efficacy advancing BECT‐immunotherapy strategies.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 16, 2024
Abstract Background Most bone defects caused by disease or trauma are accompanied infection, and there is a high risk of infection spread defect expansion. Traditional clinical treatment plans often fail due to issues like antibiotic resistance non-union bones. Therefore, the infected requires strategy that simultaneously achieves antibacterial efficiency promotes regeneration. Results In this study, an ultrasound responsive vanadium tetrasulfide-loaded MXene (VSM) Schottky junction constructed for rapid methicillin-resistant staphylococcus aureus (MRSA) clearance Due peroxidase (POD)-like activity VS 4 abundant junctions, VSM has electron–hole separation decreased band gap, exhibiting strong chemodynamic sonodynamic 94.03%. Under stimulation medical dose ultrasound, steady release element osteogenic differentiation human marrow mesenchymal stem cells (hBMSCs). The in vivo application tibial plateau rats also great therapeutic effect, eliminating MRSA then inhibiting inflammation improving Conclusion present work successfully develops -based versatile sonosensitizer robust effective therapy defects.
Language: Английский
Citations
8
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 30, 2024
The two-dimensional nanomaterials are characterized by their ultra-thin structure, diverse chemical functional groups, and remarkable anisotropic properties. Since its discovery in 2004, graphene has attracted significant scientific interest due to potential applications various fields, including electronics, energy systems, biomedicine. In medicine, is used for designing smart drug delivery especially antibiotics, biosensing. Skin trauma a prevalent dermatological condition that increasingly contributes morbidities mortalities, thus representing health burden. During tissue damage, rapid skin repair crucial prevent blood loss infection. Therefore, drugs must possess antimicrobial anti-inflammatory Two-dimensional (2D) physical, chemical, optical, biological characteristics uniform shape, increased surface area, charge. Graphene derivatives, transition-metal dichalcogenides (TMDs), black phosphorous (BP), hexagonal boron nitride (h-BN), MXene, metal-organic frameworks (MOFs) among the commonly 2D nanomaterials. Moreover, they exhibit antibacterial This review presents comprehensive discussion of clinical approaches employed wound healing treatment explores enhance outcomes.
Language: Английский
Citations
4
Materials Today, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Talanta, Journal Year: 2025, Volume and Issue: 295, P. 128293 - 128293
Published: May 10, 2025
Language: Английский
Citations
0