Nanoparticle-mediated Thermal Cancer Therapies: Strategies to Improve Clinical Translatability DOI Open Access
María Loreto Bravo, Beatrice Fortuni, Paul Mulvaney

et al.

Published: Feb. 8, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Language: Английский

Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability DOI Creative Commons
Martin Bravo, Beatrice Fortuni, Paul Mulvaney

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 751 - 777

Published: July 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Language: Английский

Citations

9
Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases DOI Creative Commons
Nora Bloise, Marialaura Giannaccari, G Guagliano

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1054 - 1054

Published: June 18, 2024

Over the past decade, development of three-dimensional (3D) models has increased exponentially, facilitating unravelling fundamental and essential cellular mechanisms by which cells communicate with each other, assemble into tissues organs respond to biochemical biophysical stimuli under both physiological pathological conditions. This section presents a concise overview most recent updates on significant contribution different types 3D cell cultures including spheroids, organoids organ-on-chip bio-printed in advancing our understanding molecular mechanisms. The case studies presented include breast cancer (BC), endometriosis, liver microenvironment infections. In BC, establishment culture permitted visualization role cancer-associated fibroblasts delivery exosomes, as well significance physical properties extracellular matrix promoting proliferation invasion. approach also become valuable tool gaining insight general specific drug resistance. Given considerable heterogeneity offer more accurate representation vivo microenvironment, thereby identification translation novel targeted therapeutic strategies. advantages provided hepatic environment, conjunction high throughput characterizing various platforms, have enabled elucidation complex underlying threatening diseases. A limited number for gut skin infections been developed. However, profound comprehension spatial temporal interactions between microbes, host their environment may facilitate advancement vitro, ex disease models. Additionally, it pave way approaches diverse research fields. interested reader will find concluding remarks challenges prospects using discovering areas covered this review.

Language: Английский

Citations

7
Interparticle interactions and magnetization relaxation of ferrimagnetic particles DOI

Shubham Rajput,

S.D. Tiwari

Solid State Communications, Journal Year: 2025, Volume and Issue: unknown, P. 115892 - 115892

Published: March 1, 2025

Language: Английский

Citations

0
Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures DOI Creative Commons

Teodora Eliana Petcov,

M. Straticiuc, D. Iancu

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(6), P. 169 - 169

Published: June 19, 2024

Nanoparticle (NP)-based solutions for oncotherapy promise an improved efficiency of the anticancer response, as well higher comfort patient. The current advancements in cancer treatment based on nanotechnology exploit ability these systems to pass biological barriers target tumor cell, cell organelles. In particular, iron oxide NPs are being clinically employed oncological management due this ability. When designing efficient anti-cancer therapy NPs, it is important know and modulate phenomena which take place during interaction with cells, normal tissues. regard, our review focused highlighting different approaches studying internalization patterns simple complex 2D 3D vitro models, living tissues, order investigate functionality NP-based treatment.

Language: Английский

Citations

4
Functional mixed metal oxide nanomaterials: a comprehensive review of their hyperthermic potential in cancer therapy DOI
Amol B. Pandhare, Swapnajit V. Mulik, Santosh S. Patil

et al.

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review provides a comprehensive and well-structured analysis of magnetic hyperthermia therapy (MHT) as potential cancer treatment.

Language: Английский

Citations

0
An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models DOI

Pratibha Parihar,

Naina Sunildutt,

Chethikkattuveli Salih Abdul Rahim

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(6)

Published: Feb. 22, 2024

Abstract Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer faithful representation of cancer vitro, exploration biology, evaluation drug efficacy, and anticipation patient responses therapies. Compared conventional ones, VToC systems hold advantages by creating milieu where physiological conditions for investigating tumor–host interactions pivotal advancement/therapy resilience. Nevertheless, models confront limitations encompassing vascular network replication, biological fidelity, mechanical/chemical integrity, intricacies architectural design. Thus, drawbacks inherent prevailing models’ intricacies, attributes, establishment imperative. This systematic review focuses the recent advancements, technologies explored incorporating models, vascularization approaches investigation, factors/parameters affecting complex microenvironments along with futuristic approach design strategies, fabrication techniques, understanding network, also spheroid. A comprehensive analysis based their practical highlights promising strategies possible applications. will be essential regarding complete overview future direction toward developing efficient compared state‐of‐the‐art VToC.

Language: Английский

Citations

3
Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release DOI
Suman Basak, Tushar Kanti Das

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered release curcumin in response phospholipase A2, an enzyme that degrades phospholipids, enabling highly targeted site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability activates thermosensitive carriers, optimizing delivery. Curcumin encapsulation facilitated through a combination zwitterionic electrostatic interactions, significantly improving both loading capacity efficiency. design experiments (DoE) approach employed systematically optimize lipid-to-cholesterol ratios formulation conditions. The thoroughly characterized using dynamic light scattering, zeta potential measurements, transmission electron microscopy, ensuring stability structural integrity. Notably, this effectively encapsulates hydrophobic while maintaining particle size bioactivity. In vitro studies revealed robust antioxidant anti-ROS activities, alongside excellent biocompatibility, with no cytotoxicity observed at concentrations up 2000 μg/mL. Furthermore, liposomes enhanced M2 macrophage polarization reduced oxidative stress. advanced offers promising, biocompatible solution

Language: Английский

Citations

2
Graphene quantum dots as nanotherapeutic agents for triple-negative breast cancer: Insights from 3D tumor models DOI
Mohammad Suhaan Dar, P. Rosaiah,

J. Bhagyalakshmi

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216247 - 216247

Published: Oct. 7, 2024

Language: Английский

Citations

1
Numerical study of magnetic nanoparticles injection into a brain tumor considering the effects of injection volume and location on the termination of cancerous cells DOI
Adeleh Kazemi Alamouti, Izaz Raouf, Saeed Zahabi

et al.

Biointerphases, Journal Year: 2024, Volume and Issue: 19(6)

Published: Nov. 1, 2024

Lately, magnetic nanoparticle (MNP) hyperthermia gained much attention because of its therapeutic efficiency. It is challenging to predict all the treatment parameters during actual environment. Hence, numerical approaches can be utilized optimize various interest. In present research, MNP on a cancerous tumor placed inside human brain investigated numerically using realistically shaped model for head layers and tumor. Applying boundary conditions, steady-state Pennes’s bioheat transfer equation solved finite element method scheme. The effects injection volume location thermal distribution are examined discussed in detail. total 5990 mm3. Three different volumes per point, namely, 0.6, 1.2, 3 μl, as well several points, performed. observed that choosing higher number points affects temperature terms uniformity. contrast, an accurate provides lower temperatures tissue. Moreover, it concluded interfaces between anatomically correct play critical role therapy. Based obtained results, optimal condition with mm3 80 μl through 20 over considering 4 each point.

Language: Английский

Citations

1
Spatially Variable Genes DOI

Shantagoud Biradar,

Chaaya Suresh,

Nagashri Nanjundeshwara

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 17, 2024

The clinical translation of spatial transcriptomics represents cancer diagnosis and therapy based on the role heterogeneity cancer-associated fibroblasts (CAFs) within tumor microenvironment (TME). Recent developments in have enabled a detailed characterization organization cellular interactions tumors. data integration, multi-omics approaches, along with developing standardized protocols is essential for effective translation. experimental selection regimes factorial designs reveals novel insights into biomarkers prognostic value CAFs. incorporation optogenetics advancements bio-engineered gene circuits, therapeutics tissue engineering further underscores potential to refine patient stratification improve treatment responsiveness. By integrating workflows, this work aims advance personalized therapies biology.

Language: Английский

Citations

0