The role of electroencephalography in epilepsy research—From seizures to interictal activity and comorbidities

Epilepsia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both basic and translational studies. Its contributions have advanced our understanding of epilepsy, shedding light on pathophysiology functional organization epileptic networks, mechanisms underlying seizures. Here we re‐examine historical significance, ongoing relevance, future trajectories EEG research. We describe traditional approaches to record brain electrical activity discuss novel cutting‐edge, large‐scale techniques using micro‐electrode arrays. Contemporary studies explore potentials beyond Berger frequencies uncover underexplored operating at ultra‐slow high frequencies, which proven valuable principles ictogenesis, epileptogenesis, endogenous epileptogenicity. Integrating with modern such as optogenetics, chemogenetics, imaging provides a more comprehensive epilepsy. become an integral element powerful suite tools capturing network dynamics across various temporal spatial scales, ranging from rapid pathological synchronization long‐term processes epileptogenesis or seizure cycles. Advancements recording parallel application sophisticated mathematical analyses algorithms, significantly augmenting information yield recordings. Beyond seizures interictal activity, elucidating epilepsy‐related cognitive deficits other comorbidities. Although remains cornerstone research, persistent challenges limited resolution, artifacts, difficulty highlight need refinement. Despite these challenges, continues be fundamental tool, playing central role unraveling disease drug discovery.

Language: Английский

A Multifunctional Software Platform developed in .net MAUI for performing Neural Stimulation with Low-Intensity Magnetic Fields

Published: Sept. 13, 2024

Language: Английский