Green synthesis of tetra-substituted 2H-pyrans catalyzed by lipase in aqueous medium

Biocatalysis and Biotransformation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: Jan. 15, 2025

An efficient and environmental method was employed to synthesize multi-substituted 2H-pyran from methyl coumalate β-keto esters or diketones. Porcine pancreas lipase (PPL) can catalyze this transformation in high yields (74–96%) aqueous medium (H2O: DMSO = 2:1) under mild conditions (60 °C). The reported strategy exhibits functional group compatibility broad substrate scope. In addition, it provides access a variety of tetra-substituted 2H-pyrans which are considered privileged scaffolds with diverse biological activities.

Language: Английский

Synthesis of coumarin dimers by a microwave-assisted double multicomponent reaction

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 42, P. 101792 - 101792

Published: Oct. 2, 2024

Language: Английский