An Iron‐Catalyzed Three‐Component Radical Cascade Cyclization to Access Cyanoalkylsulfonyl Quinolino‐Quinazolinones

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(11), P. 2456 - 2460

Published: March 21, 2024

Abstract An iron(II)‐catalyzed cascade reaction, involving cyanoalkylsulfonylation and cyclization, has been devised to enable the synthesis of functionalized sulfonylated quinolino‐quinazolinone alkyl nitriles. This three‐component radical transformation exhibits excellent chemo‐ regioselectivity while functioning without need for external oxidizing or reducing agents. The cost‐effectiveness this catalytic system, together with its broad substrate application, which includes drug molecule derivatives, make approach efficient adaptable.

Language: Английский

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Visible-light-induced photocatalyst-free cascade cyclization of 3-(2-(ethynyl)phenyl)quinazolinones to sulfonated quinolino[2,1-b]quinazolinones

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(56), P. 7228 - 7231

Published: Jan. 1, 2024

A visible-light-induced K 2 S O 8 -promoted cascade sulfonation/cyclization reaction to afford a series of sulfonated quinolino[2,1- b ]quinazolinones has been developed under mild conditions.

Language: Английский

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Visible-Light-Induced Cascade Cyclization of 1-(2-(Arylethynyl)benzoyl)indoles into Sulfonated Benazepino[1,2-a]indolones

Organic Letters, Journal Year: 2024, Volume and Issue: 26(50), P. 10982 - 10987

Published: Dec. 10, 2024

1-(2-(Arylethynyl)benzoyl)indoles were developed as an innovative scaffold for radical cascade cyclization under visible-light and mild conditions, enabling efficient synthesis of sulfonated benazepino[1,2-

Language: Английский

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Recent advances in radical thiocyanation cyclization or spirocyclization reactions

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(46), P. 9112 - 9122

Published: Jan. 1, 2023

Organic thiocyanates are valuable biological moities and drug-building blocks. They can also transform effectively into thioethers, thiols, alkynyl thiocarbamates in synthetic chemistry. With respect to the merits of thiocyanates, many chemists our research team have developed diverse strategies access SCN-revised heterocycles/spirocycles via an effective radical cyclization process. Hence, this review article first describes importance/application thiocyanates. Subsequently, it summarizes reaction conditions, substrate scopes, plausible mechanism, respectively, excellent work stated above.

Language: Английский

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Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-b]quinazolinones

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(62), P. 8119 - 8122

Published: Jan. 1, 2024

A novel visible-light promoted metal-free radical cascade cyclization reaction has been developed with 3-allyl-2-arylquinazolinones as a new class of acceptor. This photocatalytic protocol represents an efficient approach to construct phosphorylated dihydroisoquinolino[1,2-

Language: Английский

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Synthetic developments on the preparation of thioethers via photocatalysis

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 49(3), P. 651 - 668

Published: Dec. 10, 2024

Sulfide is a widely occurring natural product and pharmaceutically active compound. This review highlights the photochemically mediated thioether synthesis reactions, with emphasis on catalytic mechanism.

Language: Английский

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