Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Due
to
the
special
structure
and
physicochemical
properties
of
sulfoximines,
research
on
sulfoximines
has
achieved
great
progress
in
recent
decades,
especially
chemical
medicinal
fields.
This
review
highlights
advancements
N-functionalization
NH-sulfoximines,
focusing
classical
cross-coupling
reactions
with
electrophilic
agents
oxidative
coupling
extensive
organic
compounds,
including
specific
(hetero)arenes,
alkenes
(1,4-naphthoquinones),
alkanes
(cyclohexanes),
nucleophiles
(thiols,
disulfides,
sulfinates,
diarylphosphine
oxides),
organyl
boronic
acids,
arylhydrazines.
Transition
metal-catalyzed,
metal-free,
electrochemical
radical
are
discussed.
also
reports
discusses
mechanistic
pathways
some
typical
reactions.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Comprehensive
Summary
The
N–H
methylsulfoxidation
of
sulfoximines
using
DMSO
as
a
methylsulfinyl
source,
induced
by
electrochemistry,
has
been
developed.
This
method
is
the
first
example
an
electrochemical
reaction
in
which
serves
source.
Unlike
previous
reactions
involving
substrate,
exclusively
proceed
via
radical
mechanisms,
this
follows
S‐cation
pathway.
A
wide
range
N
‐methylsulfinyl
were
successfully
obtained.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
The
integration
of
trifluoroacetyl
(CF3CO)
groups
into
organic
skeletons
is
a
key
research
topic
in
synthetic
chemistry
given
their
significant
potential
to
boost
biological
activity.
Despite
recent
developments
strategies
for
incorporating
moiety
via
radical
intermediates,
the
practical
utilization
inexpensive
and
readily
available
trifluoroacetic
acids
as
sources
has
not
yet
been
developed.
Herein,
an
electrochemical
strategy
employed
achieve
deoxygenative
transformation
directly
with
assistance
PPh3.
obtained
radicals
are
then
coupled
sulfoximine
species,
thus
enabling
synthesis
N-trifluoroacetylated
sulfoximines.
Additionally,
other
fluorinated
alkyl
carboxylic
acids,
including
perfluoro-,
difluoro-,
trifluoromethylcarboxylic
can
also
be
efficiently
utilized
under
these
conditions,
leading
corresponding
acylated
Moreover,
trifluoroacetylation
drug-based
molecules
easy
execution
scale-up
experiments
highlight
applicability
this
protocol.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(23), P. 6790 - 6796
Published: Jan. 1, 2024
An
electrochemically
driven
C–S
radical–radical
cross-coupling
reaction
between
benzyl
halides
and
disulfides
for
the
synthesis
of
benzylic
thioethers
has
been
developed
under
environmentally
friendly
mild
conditions.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(29), P. 5907 - 5912
Published: Jan. 1, 2024
An
electrochemically
promoted
oxidative
dehydrogenation
cross-coupling
reaction
between
aldehyde
hydrazones
and
thiophenols
is
demonstrated
for
the
first
time,
which
results
in
a
variety
of
thioetherified
products
moderate
to
excellent
yields.
Current Green Chemistry,
Journal Year:
2024,
Volume and Issue:
12(2), P. 85 - 116
Published: Sept. 26, 2024
In
the
realm
of
synthetic
organic
chemistry,
environmentally
friendly
manipulation
small
molecules
has
gained
prominence.
One
particularly
promising
approach
is
electrochemical
synthesis,
which
offers
a
green
and
sustainable
alternative
to
using
hazardous
toxic
redox
reagents.
By
harnessing
electric
current
from
renewable
sources
like
sunlight
or
wind,
synthesis
emerges
as
viable
replacement
for
conventional
methods.
This
review
article
provides
comprehensive
exploration
method,
delving
into
its
background
applications
in
synthesizing
transforming
various
molecules,
including
sulfoximines,
isoxazolines,
benzimidazoles,
more.
aims
shed
light
on
potential
greener
more
way
conducting
transformations.
Reviewing
photocatalytic
and
metal-catalyzed
disulfide
synthesis,
2021–2024,
emphasizes
efficiency,
selectivity,
sustainability
for
drug
material
science.
