Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium DOI Creative Commons

Xiaoshan Gong,

Hao Tang,

Jingjin Dai

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Osteoarthritis (OA) is characterized mainly by articular cartilage loss, subchondral osteosclerosis, and chronic inflammation involves multiple types of cellular dysfunction tissue lesions. The rapid development nanotechnology materials science has contributed to the application biomimetic nanomaterials in biomedical field. By optimizing composition, hardness, porosity, drug loading nanomaterials, their unique physicochemical properties drive potential applications bone repair. This article reviews present understanding physiopathological mechanism clinical treatment drawbacks OA summarizes various for that target lesion sites, such as cartilage, bone, synovium, through simulation physiological structure microenvironment. Eventually, challenges prospects translation are further discussed, with goal accessing an effective approach treatment.

Language: Английский

Nanogels in Biomedical Engineering: Revolutionizing Drug Delivery, Tissue Engineering, and Bioimaging DOI

Atieh Janmaleki Dehchani,

Aliakbar Jafari,

Farangis Shahi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)

Published: Oct. 1, 2024

ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.

Language: Английский

Citations

11
Gold capped mesoporous bioactive glass guides bone regeneration via BMSCs recruitment and drug adaptive release DOI

Dong Zhou,

Xuan Yan, Lan Xiao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150546 - 150546

Published: March 20, 2024

Language: Английский

Citations

5
Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels DOI Creative Commons
Bing Ma, Qing Li, Jingjing Zhang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(1), P. 40 - 40

Published: Jan. 11, 2024

The present study focused on the design and preparation of acid-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for a controlled, slow-release Doxorubicin HCl (DOX.HCl). BIMIXHAC was crosslinked with sodium tripolyphosphate (TPP) using ion crosslinking method. method resulted in low polydispersity index, small particle size, positive zeta potential values, indicating good stability nanogels. Compared to hydroxypropyl trimethyl chloride chitosan-Doxorubicin HCl-sodium (HACC-D-TPP) nanogel, salt-Doxorubicin (BIMIXHAC-D-TPP) nanogel show higher drug encapsulation efficiency loading capacity (BIMIXHAC-D-TPP 93.17 ± 0.27% 31.17 0.09%), release profiles accelerated vitro. chitosan-sodium (HACC-TPP), salt-sodium (BIMIXHAC-TPP) demonstrated favorable antioxidant capability. assay cell viability, measured by MTT assay, revealed that led significant reduction viability two cancer cells: human lung adenocarcinoma epithelial line (A549) breast (MCF-7). Furthermore, BIMIXHAC-D-TPP 2.96 times less toxic than DOX.HCl mouse fibroblast (L929). It indicated BIMIXHAC-based enhanced antitumor activities acidic-responsive could serve as nanocarrier.

Language: Английский

Citations

4
Exploring the Potential of Nano-Biomaterials in Tissue Engineering DOI

Giriraj Pandey,

Tejaswini Kolipaka,

Vivek Phatale

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

4
3D-Printed Cell-adaptable Nanocolloidal Hydrogel Induces Endogenous Osteogenesis for Bone Repair DOI Creative Commons

Wenxin Lu,

Li Li,

Ruyi Wang

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Repairing critical bone defects remains a formidable challenge in regenerative medicine. Scaffolds that can fill and facilitate regeneration have garnered considerable attention. However, scaffolds struggle to provide an ideal microenvironment for cell growth differentiation at the interior of defect sites. The scaffold's structure must meet specific requirements support endogenous regeneration. Here, we introduce novel 3D-printed nanocolloidal gelatin methacryloyl (GelMA) hydrogel, namely, nG was derived from self-assembly GelMA presence Pluronics F68, emphasizing its osteoinductive capability conferred solely by structure. exhibiting remarkable pore connectivity cell-adaptable microscopic structure, induced infiltration migration rat mesenchymal stem cells (rBMSCs) into hydrogel with large spreading area vitro. Moreover, interconnected nanospheres promoted osteogenic rBMSCs, leading up-regulated expression ALP, RUNX2, COL-1, OCN, as well augmented formation calcium nodules. In critical-sized calvarial model, demonstrated improved repair defects, enhanced recruitment CD29+ CD90+ increased regeneration, indicated significantly higher mineral density (BMD) vivo. Mechanistically, integrin β1/focal adhesion kinase (FAK) mechanotransduction signaling pathway group both vitro vivo, which may partially account pronounced capability. conclusion, shows great potential near-future clinical translational strategy customized defects.

Language: Английский

Citations

0
Polymeric Drug Delivery Systems in Biomedicine DOI

I. A. Gulyaev,

Maria Sokol, Mariia R. Mollaeva

et al.

Biochemistry (Moscow), Journal Year: 2025, Volume and Issue: 90(S1), P. S233 - S262

Published: Feb. 1, 2025

Language: Английский

Citations

0
Endothelin and Bradykinin Long-Term Antagonisms by Peptide-Grafted Nanogels for the Treatment of Osteoarthritis: A Proof-of-Concept Study DOI

Seng Manivong,

Araceli Ac Garcia,

Louiza Mahrouche

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Innovative Approaches in Bone Tissue Engineering: Strategies for Cancer Treatment and Recovery DOI Open Access

Samiksha Khobragade,

Manish Deshmukh,

Ujwal Vyas

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3937 - 3937

Published: April 22, 2025

Cancer has rapidly emerged as a leading global cause of premature mortality, with significant economic implications projected to reach USD 25.2 trillion from 2020 2050. Among the various types cancer, primary bone cancers, though uncommon, are see nearly 4000 new cases diagnosed in United States 2024. The complexity treating cancer arises its rarity, diversity, and challenges associated surgical interventions, metastatic spread, post-operative complications. Advancements tissue engineering (BTE) have introduced innovative therapeutic approaches promote regeneration address tumor recurrence. This interdisciplinary field integrates biomaterials, scaffolds, gene therapy, utilizing technologies such 3D bioprinting create custom scaffolds that facilitate cellular activities essential for regeneration. Recent developments biodegradable, bioactive materials aim enhance biocompatibility effectiveness while nanotechnology presents promising avenues targeted drug delivery improved outcomes. review outlines current landscape BTE, highlighting scaffold fabrication techniques, advantages incorporating stem cell therapies, future directions, including integration artificial intelligence design personalized medicine orthopedic oncology. work underscores necessity ongoing research innovation, aiming improve strategies specifically designed unique posed by sarcomas cancers.

Language: Английский

Citations

0
Amine-Polyether-Epoxide Nanoplatform-Driven Seed Germination, Plant Growth, and Nutrient Uptake for Sustainable Agriculture DOI Creative Commons
Bruno A. Fico, Heber E. Andrada,

Felipe B. Alves

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Polymeric systems can facilitate the diffusion of micronutrients through seeds, offering an innovative and sustainable way to improve plant health increase food production. In present work, a polymeric nanogel based on polyether-POE-diamine bisepoxide was synthesized in-depth characterized, encompassing its morphological characteristics (by Transmission Electron Microscopy, TEM), size distribution, surface charge particles dynamic light scattering, DLS zeta potential, ζ). The formation network assessed using Fourier-transform infrared spectroscopy (FTIR) proton nuclear magnetic resonance (1H NMR), confirming opening epoxide ring amine glycol groups. effects seed priming with (well-defined spherical particles, sizes around 120 nm, named POE-gel) early growth stage cucumber plants (Cucumis sativus) exhibited discernible ameliorative impact root shoot lengths, average improvements 33% 90%, respectively, compared control group after 12 days. Extensive investigation germination assays micro X-ray fluorescence (μ-XRF) analysis indicated potential applications POE-gel as carrier for (such Fe3+). seeds treated iron-loaded presented substantial positive effect length, exhibiting 3-fold in control-Fe treatment at same concentration. loaded effectively penetrated compartments, providing even distribution iron ions facilitating uptake nutrients (K, Mn, Zn) by seeds. Toxicological zebrafish (Danio rerio), leaves revealed notable safety unloaded agricultural purposes. Employing water only solvent synthesis, well eliminating use catalyst, makes this class suitable applications. findings work contribute development agriculture, presenting approach enhancing nutrient application nanogels technology.

Language: Английский

Citations

0
Stimuli-responsive smart materials: Bridging the gap between biotechnology and regenerative medicine DOI

Karthik K Karunakar,

Binoy Varghese Cheriyan, Ragavendran Anandakumar

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: 48, P. e00415 - e00415

Published: April 15, 2025

Language: Английский

Citations

0