Recent Advances in Micro/Nanomotor for the Therapy and Diagnosis of Atherosclerosis DOI
Yusheng Qin, Juan Yi,

Yanjun Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(8), P. 11443 - 11468

Published: Dec. 9, 2024

Atherosclerotic cardiovascular disease poses a significant global public health threat with high incidence that can result in severe mortality and disability. The lack of targeted effects from traditional therapeutic drugs on atherosclerosis may cause damage to other organs tissues, necessitating the need for more focused approach address this dilemma. Micro/nanomotors are self-propelled micro/nanoscale devices capable converting external energy into autonomous movement, which offers advantages enhancing penetration depth retention while increasing contact area abnormal sites, such as atherosclerotic plaque, inflammation, thrombosis, within blood vessel walls. Recent studies have demonstrated crucial role micro/nanomotors play treating disease. Hence, review highlights recent progress micro/nanomotor technology disease, including effective promotion circulatory system, overcoming hemorheological barriers, targeting plaque microenvironment, intracellular drug delivery, facilitate localization therapy. Furthermore, we also describe potential application imaging vulnerable plaque. Finally, discuss key challenges prospects emphasizing importance designing individualized management strategies specific its causes microenvironmental factors.

Language: Английский

Temperature‐Sensitive Polymer‐Driven Nanomotors for Enhanced Tumor Penetration and Photothermal Therapy DOI

Beng Ma,

Ying Yu, Jiayi Li

et al.

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: Aug. 20, 2024

Abstract Self‐propelled nanomotors possess strong propulsion and penetration abilities, which can increase the efficiency of cellular uptake nanoparticles enhance their cytotoxicity against tumor cells, opening a new path for treating major diseases. In this study, concept driving by alternately stretching contracting temperature‐sensitive polymer (TS‐P) chain is proposed. The TS‐Ps are successfully linked to one side Cu 2‐x Se@Au (CS@Au) form Janus structure, designated as Se@Au‐polymer (CS@Au‐P) nanomotors. Under near‐infrared (NIR) light irradiation, Se generate photothermal effects that change system temperature, triggering alternation TS‐P structure mechanical force propels motion CS@Au‐P nanomotor significantly improved enhanced accumulation in tumor. Furthermore, exceptional conversion suggests potential nanomaterials therapy (PTT). prepared material exhibited good biocompatibility anti‐tumor both vivo vitro, providing research insights into design application therapy.

Language: Английский

Citations

5
NIR-II Light-Actuated Nanomotors for Enhanced Photoimmunotherapy Toward Hepatocellular Carcinoma DOI
Yi‐Chi Chen, Wenxin Xu,

Huimin Tian

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 39051 - 39063

Published: July 19, 2024

Light-propelled nanomotors, which can convert external light into mechanical motion, have shown considerable potential in the construction of a new generation drug delivery systems. However, therapeutic efficacy light-driven nanomotors is always unsatisfactory due to limited penetration depth near-infrared-I (NIR-I) and inherent biocompatibility motor itself. Herein, an asymmetric nanomotor (Pd@ZIF-8/R848@M JNMs) with efficient motion capability successfully constructed for enhanced photoimmunotherapy toward hepatocellular carcinoma. Under near-infrared-II (NIR-II) irradiation, Pd@ZIF-8/R848@M JNMs energy heat energy, exhibiting self-thermophoretic locomotion penetrate deeper tumor tissues achieve photothermal therapy. At same time, functionalized immune-activated agent Resiquimod (R848), our could "cold tumor" "hot tumor", transforming immunosuppressive microenvironment state, thus achieving immunotherapy. Dual as-developed NIR-II demonstrates inhibition effects, offering promising approach field anticancer

Language: Английский

Citations

4
Advancements in Visible Light-Driven Micro/nanomotors for Photodegradation of Environmental Pollutants DOI Creative Commons
Vanessa R.A. Ferreira, Manuel Azenha

Environmental Science Advances, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Recent advances (2020–2024) in visible light-driven motors to enhance pollutant photodegradation are reviewed. An overview of challenges and perspectives for future research is provided.

Language: Английский

Citations

4
Navigating Therapeutic Opportunities and Challenges with Micro/Nanomotors in Translational Medicine: A Review DOI Creative Commons

Qingwei Zhou,

Yu Kong, Xinyi Zhou

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(20), P. 23321 - 23336

Published: Oct. 12, 2024

With the improvement of micromanufacturing technology and further elucidation propulsion mechanism, manufacture application micro/nanomotors have made great progress. However, in translational medicine is still its infancy, promise research remains to be fully realized. In this paper, preparation status their prospects were reviewed. The representative clinical value introduced. addition, paper also analyzes possible reasons for low conversion rate proposes current challenges future indicate a direction medicine.

Language: Английский

Citations

3
Advancements in Micro/Nanorobots in Medicine: Design, Actuation, and Transformative Application DOI Creative Commons
Induni Nayodhara Weerarathna, Praveen Kumar, Hellen Yayra Dzoagbe

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5214 - 5250

Published: Feb. 4, 2025

In light of the ongoing technological transformation, embracing advancements that foster shared benefits is essential. Nanorobots, a breakthrough within nanotechnology, have demonstrated significant potential in fields such as medicine, where diagnostic and therapeutic applications are primary focus areas. This review provides comprehensive overview robots, their evolving role medical applications, particularly highlighting use nanorobots. Various design strategies operational principles, including sensors, actuators, nanocontrollers, discussed based on prior research. Key nanorobot include biomedical imaging, biosensing, minimally invasive surgery, targeted drug delivery, each utilizing advanced actuation technologies to enhance precision. The paper further examines recent progress micro/nanorobot addresses important considerations for future, biocompatibility, control, navigation, targeting, safety, ethical implications. offers holistic perspective how nanorobots can reshape practices, paving way precision medicine improved patient outcomes.

Language: Английский

Citations

0
Micro/nanomotors in targeted drug delivery: Advances, challenges, and future directions DOI

Hui Ma,

Ruifang Li,

Zi‐Li Yu

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125471 - 125471

Published: March 1, 2025

Language: Английский

Citations

0
Acoustic-Magnetic Responsive Nanomotor Augments Oral Drug Delivery by Gastrointestinal Site Navigation and Mucus Layer Penetration DOI
Zhi‐Hao Wang,

Xuejiao Zeng,

Shuhao Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Oral administration is a traditional, safe, and widely used drug delivery strategy. However, the efficiency of oral system hindered by long gastrointestinal tract, filled with dense viscous mucus. Herein, we presented an acoustic-magnetic responsive nanomotor (MMSNP) for via site navigation mucus layer penetration. MMSNP has Janus rod-shaped structure composed iron tetroxide mesoporous silica, which could be guided to various intestinal segments external magnetic field based on demand different diseases. In addition, rod-like effectively penetrate under ultrasound radiation improve bioavailability loaded drugs. diabetes rats, small penetration increased relative metformin (Met) 78.0% effective hypoglycemic time 1.1-fold than pure Met. orthotopic colorectal cancer (CRC)-bearing mice, magnetically mediated anchoring nanomotors 4.2-fold, propulsion 5.2-fold, leading vastly improved cisplatin (CP) superior tumor inhibition rate 97.2%. This simple versatile broad application prospects in treatment diseases, providing promising universal strategy clinical conversion orally administered

Language: Английский

Citations

0
Recent Advances in Light-Driven Semiconductor-Based Micro/Nanomotors: Optimization Strategies and Emerging Applications DOI Creative Commons
Vanessa R.A. Ferreira, Manuel Azenha

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1154 - 1154

Published: March 5, 2024

Micro/nanomotors represent a burgeoning field of research featuring small devices capable autonomous movement in liquid environments through catalytic reactions and/or external stimuli. This review delves into recent advancements light-driven semiconductor-based micro/nanomotors (LDSM), focusing on optimized syntheses, enhanced motion mechanisms, and emerging applications the environmental biomedical domains. The survey commences with theoretical introduction to micromotors their propulsion followed by an exploration commonly studied LDSM, emphasizing advantages. Critical properties affecting propulsion, such as surface features, morphology, size, are presented alongside discussions conditions related light sources intensity, which crucial for optimizing speed. Each property is accompanied background conclusions drawn up 2018. further investigates adaptations uncovering underlying mechanisms associated benefits. A brief discussion included potential synergistic effects between different conditions, aiming enhance efficiency-a relatively underexplored topic. In conclusion, outlines biomedicine monitoring/remediation resulting from LDSM research, highlighting growing significance this field. comprehensive provides valuable insights researchers practitioners seeking leverage these innovative diverse applications.

Language: Английский

Citations

2
Urease-powered micro/nanomotors: Current progress and challenges DOI Creative Commons
Wenwen Li, Zi‐Li Yu,

Jun Jia

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101095 - 101095

Published: Sept. 1, 2024

Enzyme-powered micro/nanomotors (MNMs) (EMNMs) use natural enzymes to facilitate the decomposition of fuels, including hydrogen peroxide (H2O2), glucose, triglycerides, and urea provide power. EMNMs can achieve self-propulsion through in situ utilization biofuels without additional exhibiting excellent biocompatibility significant potential for application biomedical field. Compared with H2O2, which may cause oxidative damage body, exhibits superior biosafety characteristics. Presently, urease-powered MNMs (UMNMs) have made notable progress their applications field garnered considerable attention from researchers. In this review, we present latest advancements UMNMs, primarily focusing on: 1) diverse materials used constructing fundamental framework motors; 2) control motor movement regulation enzymatic reaction rates; 3) research directions clinical motors, vivo imaging, biomarker detection, cancer treatment, optical therapy, overcoming biological barriers, antibacterial interventions, antithrombotic strategies, gastric disease management. Despite showing immense applications, there are still several challenges impeding its practical implementation, such as maintaining activity environment while accurately targeting specific sites desired therapeutic effects.

Language: Английский

Citations

1
Autonomous Nanorobots as Miniaturized Surgeons for Intracellular Applications DOI Creative Commons
D. Tang, Xiqi Peng, Song Wu

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 595 - 595

Published: March 28, 2024

Artificial nanorobots have emerged as promising tools for a wide range of biomedical applications, including biosensing, detoxification, and drug delivery. Their unique ability to navigate confined spaces with precise control extends their operational scope the cellular or subcellular level. By combining tailored surface functionality propulsion mechanisms, demonstrate rapid penetration cell membranes efficient internalization, enhancing intracellular delivery capabilities. Moreover, robust motion within cells enables targeted interactions components, such proteins, molecules, organelles, leading superior performance in biosensing organelle-targeted cargo Consequently, hold significant potential miniaturized surgeons capable directly modulating dynamics combating metastasis, thereby maximizing therapeutic outcomes precision therapy. In this review, we provide an overview modes discuss essential factors harness propulsive energy from local environment external power sources, structure, material, engine selection. We then key advancements nanorobot technology various applications. Finally, address important considerations future design facilitate translation into clinical practice unlock full research healthcare.

Language: Английский

Citations

1