An Oxidation-Reduction-Triggered Thiamine Disulfide-Based Prodrug of 10-Hydroxycamptothecin for Selective Tumor Cell Locking and Therapeutic Delivery DOI

Chunyan Yang,

Peiyun Yu, Jinxia Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 284, P. 117233 - 117233

Published: Dec. 31, 2024

Language: Английский

Ferulic Acid: A Comprehensive Review DOI Open Access

J. Purushothaman,

Md. Rizwanullah

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Ferulic acid (FA), a phenolic compound abundant in the cell walls of seeds, leaves, and roots various fruits, vegetables, cereals, grains, is renowned for its wide range biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. Despite therapeutic potential, clinical application FA hindered by challenges such as poor water solubility, limited bioavailability, rapid metabolism, instability under physiological conditions. To address these issues, nanotechnology has emerged transformative approach, enhancing FA's pharmacokinetic profile. Various nanoparticle-based systems, polymer-based lipid-based nanoparticles, have been developed to encapsulate FA. These systems demonstrated significant improvements stability, with studies showing enhanced antioxidant activity controlled release profiles. Further, surface engineering nanoparticles provides targeted drug/phytochemical delivery potential. The drugs/phytochemicals significantly enhances efficacy minimizes systemic side effects. This review explores potential FA, limitations application, advancements that are paving way effective use.

Language: Английский

Citations

4
Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases DOI Creative Commons

Limei Cui,

Yujuan Yang, Hao Yan

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 10, 2025

Under the concept of "one airway, one disease", upper and lower airway inflammatory diseases share similar pathogenic mechanisms are collectively referred to as diseases. With industrial development environmental changes, incidence these has gradually increased. Traditional treatments, including glucocorticoids, antihistamines, bronchodilators, have alleviated much discomfort experienced by patients. However, conventional drug delivery routes inherent flaws, such significant side effects, irritation respiratory mucosa, issues related deactivation. In recent years, nanomaterials emerged excellent carriers for being increasingly utilized in treatment These materials not only optimize traditional medications but also facilitate administration various new drugs that target novel pathways, thereby enhancing outcomes This study reviews latest research on nano-drug systems used diseases, covering drugs, immunotherapy antimicrobial plant-derived RNA drugs. The challenges involved developing nano-delivery discussed, along with a future outlook. review offers insights researchers can utilize advance further into clinical application treating

Language: Английский

Citations

0
Eupatilin unveiled: An in-depth exploration of research advancements and clinical therapeutic prospects DOI
Zheng Li, Xiumei Wang,

Ksenija Tasich

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Eupatilin, a flavonoid found in Artemisia argyi (Compositae) leaves, exhibits robust anti-inflammatory, antioxidant, and anti-tumor properties. Numerous investigations have demonstrated remarkable efficacy of eupatilin across various disease models, spanning digestive, respiratory, nervous, dermatological conditions. This review aims to provide an overview recent studies elucidating the mechanistic actions spectrum models evaluate its clinical applicability. The findings herein valuable insights for advancing study novel Traditional Chinese Medicine compounds their utilization.

Language: Английский

Citations

0
Editorial: Emerging advances in exploiting pulmonary administration for treatment of thoracic diseases DOI Creative Commons
Lina Wu,

Gregory M. Lanza,

Jin Xie

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 25, 2025

Language: Английский

Citations

0
Revolutionizing Lung Cancer Treatment with Smart Pulmonary Drug Delivery Nanosystems DOI

Osman Gamal,

Abdullah T. Agamey,

Zeinab A. Mohamed

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106158 - 106158

Published: Sept. 6, 2024

Language: Английский

Citations

3
Fabrication of Luteolin Nanoemulsion by Box-Behnken Design to Enhance its Oral Absorption Via Lymphatic Transport DOI
Liangxing Tu, Wang Ju, Yongbing Sun

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(7)

Published: Sept. 5, 2024

Language: Английский

Citations

2
Nanomedicines for Pulmonary Drug Delivery: Overcoming Barriers in the Treatment of Respiratory Infections and Lung Cancer DOI Creative Commons
Raquel Fernández-García, Ana Isabel Fraguas‐Sánchez

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1584 - 1584

Published: Dec. 11, 2024

The pulmonary route for drug administration has garnered a great deal of attention in therapeutics treating respiratory disorders. It allows the delivery drugs directly to lungs and, consequently, maintenance high concentrations at action site and reduction systemic adverse effects compared other routes, such as oral or intravenous. Nevertheless, is challenging, system tries eliminate inhaled particles, being main responsible mucociliary escalator. Nanomedicines represent primary strategy overcome limitations this they can be engineered prolong retention avoid their clearance while reducing distribution effects. This review analyses use pulmonary-administered nanomedicines treat infectious diseases affecting lung carcinoma, two pathologies that major health threats.

Language: Английский

Citations

2
Size-tailored and acid-degradable polyvinyl alcohol microgels for inhalation therapy of bacterial pneumonia DOI
Xiang Zhou, Jingjing Zhou,

Lanlan Wang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9325 - 9334

Published: Jan. 1, 2024

The schematic illustrates the pulmonary distribution of various sizes G@PIP upon inhalation, and degradation within microacidic lung environment to facilitate release PIP antibiotic for treating infections.

Language: Английский

Citations

1
Pulmonary Drug Delivery through Responsive Materials DOI Creative Commons
Νικόλαος Πολιτάκος, Vasilis G. Gregoriou, Christos L. Chochos

et al.

Macromol—A Journal of Macromolecular Research, Journal Year: 2024, Volume and Issue: 4(3), P. 490 - 508

Published: July 11, 2024

Drug delivery is essential to provide correct treatments in many ways. The critical points any drug method are patient compliance, maximum efficacy therapy, minimum toxicity, and enabling new medical treatments. Pulmonary one way of delivering therapeutics locally systemically. lung microenvironment mechanical biological barriers must be surpassed for successful delivery. This makes the challenging. Formulations that can delivered through have a responsive character great interest since they hold key therapeutics. review has gathered fundamental studies related materials (polymeric, lipidic, inorganic, biomolecules) pH, enzymes, ROS, magnetism, other variables, it shows advances applications pulmonary different diseases vitro as well vivo.

Language: Английский

Citations

0
An Oxidation-Reduction-Triggered Thiamine Disulfide-Based Prodrug of 10-Hydroxycamptothecin for Selective Tumor Cell Locking and Therapeutic Delivery DOI

Chunyan Yang,

Peiyun Yu, Jinxia Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 284, P. 117233 - 117233

Published: Dec. 31, 2024

Language: Английский

Citations

0