Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Sept. 17, 2024
With
the
size
of
aging
population
increasing
worldwide,
effective
diagnosis
and
treatment
neurodegenerative
diseases
(NDDs)
has
become
more
important.
Two-dimensional
(2D)
materials
offer
specific
advantages
for
NDDs
due
to
their
high
sensitivity,
selectivity,
stability,
biocompatibility,
as
well
excellent
physical
chemical
characteristics.
As
such,
2D
a
promising
avenue
development
highly
sensitive,
selective,
biocompatible
theragnostics.
This
review
provides
an
interdisciplinary
overview
advanced
use
in
biosensors,
drug
delivery,
tissue
engineering/regenerative
medicine
and/or
NDDs.
The
material-based
biosensors
enabled
early
detection
monitoring
via
precise
biomarkers
or
biological
changes,
while
delivery
systems
targeted
controlled
release
therapeutics
brain,
crossing
blood-brain
barrier
enhancing
effectiveness.
In
addition,
when
used
engineering
regenerative
medicine,
facilitate
cell
growth,
differentiation,
regeneration
restore
neuronal
functions
repair
damaged
neural
networks.
Overall,
show
great
promise
NDDs,
thus
improving
quality
life
patients
population.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 4, 2024
Nanomedicine
has
the
potential
to
transform
healthcare
by
offering
targeted
therapies,
precise
diagnostics,
and
enhanced
drug
delivery
systems.
The
National
Institutes
of
Health
coined
term
"nanomedicine"
describe
use
nanotechnology
in
biological
system
monitoring,
control,
diagnosis,
treatment.
continues
receive
increasing
interest
for
rationalized
therapeutics
pharmaceutical
agents
achieve
required
response
while
reducing
its
side
effects.
However,
as
advance,
concerns
about
toxicological
effects
have
also
grown.
This
review
explores
current
state
nanomedicine,
focusing
on
types
nanoparticles
used
their
associated
properties
that
contribute
nanotoxicity.
It
examines
mechanisms
through
which
exert
toxicity,
encompassing
various
cellular
molecular
interactions.
Furthermore,
it
discusses
assessment
methods
employed
evaluate
nanotoxicity,
in-vitro
in-vivo
models,
well
emerging
techniques.
addresses
regulatory
issues
surrounding
nanotoxicology,
highlighting
challenges
developing
standardized
guidelines
ensuring
secure
translation
nanomedicine
into
clinical
settings.
ethical
with
understanding
safety
profile
is
essential
effective
therapeutic
applications.
Discover Nano,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 16, 2025
Abstract
Phytonanoparticles
have
emerged
as
a
promising
class
of
biomaterials
for
enhancing
bone
regeneration
and
osseointegration,
offering
unique
advantages
in
biocompatibility,
multifunctionality,
sustainability.
This
comprehensive
review
explores
the
synthesis,
characterization,
applications
phytonanoparticles
tissue
engineering.
The
green
synthesis
approach,
utilizing
plant
extracts
reducing
stabilizing
agents,
yields
nanoparticles
with
intrinsic
bioactive
properties
that
can
synergistically
promote
osteogenesis.
We
examine
mechanisms
by
which
phytonanoparticles,
particularly
those
derived
from
gold,
silver,
zinc
oxide,
influence
key
molecular
pathways
osteogenesis,
including
RUNX2
Osterix
signaling.
discusses
advanced
strategies
phyto-nanoparticle
design,
such
surface
functionalization
stimuli-responsive
release
mechanisms,
enhance
their
efficacy
applications.
Preclinical
studies
demonstrating
improved
osteoblast
proliferation,
differentiation,
mineralization
are
critically
analyzed,
along
emerging
clinical
data.
Despite
results,
scalability,
standardization,
regulatory
approval
challenges
persist.
also
addresses
economic
environmental
implications
production.
Looking
ahead,
we
identify
research
directions,
developing
personalized
therapies,
combination
approaches
stem
cells
or
gene
delivery,
long-term
safety
assessments.
By
harnessing
power
plant-derived
nanomaterials,
represent
an
innovative
approach
to
addressing
complex
regeneration,
potential
spanning
dental,
orthopedic,
maxillofacial
surgery.
Graphical
abstract
Animal Cells and Systems,
Journal Year:
2025,
Volume and Issue:
29(1), P. 135 - 148
Published: Feb. 11, 2025
Circadian
rhythms
are
24-hour
cycles
in
various
biological
processes,
such
as
sleep,
wake,
and
hormone
secretion,
controlled
by
an
internal
clock.
Disruption
of
circadian
has
been
related
to
human
diseases.
Abnormal
expression
rhythm-related
genes,
CLOCK,
BMAL1,
PER1,
PER2,
CRY1,
CRY2,
RORα,
NPAS2,
REV-ERBα
TIMELESS
also
reported
be
associated
with
cancer.
NPAS2
cancer
development.
In
contrast,
RORα
inhibit
development
progression.
Furthermore,
studies
suggest
that
genes
can
regulated
ncRNAs
miRNAs,
lncRNAs
circRNAs
dysregulation
these
contributes
Here,
we
summarize
the
mechanisms
whereby
ncRNA
leads
abnormal
several
cancers
gene-associated
regulatory
contribute
resistance
chemo
–
radiotherapy.
This
review
provides
insights
into
mechanistic
involvements
network
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 1, 2025
Gastric
cancer
(GC)
is
an
exceedingly
aggressive
disease
and
ranks
as
the
third
leading
cause
of
cancer-related
deaths,
which
poses
a
huge
health
burden
globally.
Chemotherapy
commonly
employed
during
middle
to
advanced
stages
cancer,
although
it
faces
frequent
treatment
failures
attributed
drug
resistance.
Thus,
imperative
for
researchers
identify
potential
targets
overcoming
therapeutic
resistance,
thereby
facilitating
development
novel
anti-cancer
agents
GC
patients
with
stages.
Long
noncoding
RNAs
(lncRNAs)
are
diverse
group
transcripts
limited
protein-coding
capacity,
have
been
recognized
functional
molecules
regulating
progression
including
cell
proliferation,
metastasis,
resistance
in
GC.
In
this
review,
we
examine
intricate
molecular
networks
on
role
lncRNAs
LncRNAs
conferred
through
various
mechanisms,
therefore
functioning
promising
patients.
Additionally,
discuss
current
advancements
strategies
targeting
therapy,
may
pave
way
lncRNA-mediated
precision
medicine
malignant
disease.
