Mechanisms of Action of AGuIX as a Pan-Cancer Nano-Radiosensitizer: A Comprehensive Review

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 519 - 519

Published: April 2, 2025

Objective: This review provides an overview of the current knowledge regarding mechanisms action AGuIX, a clinical-stage theranostic nano-radiosensitizer composed gadolinium. It covers steps following administration, from internalization in tumor cells to interaction with X-rays and subsequent physical, chemical, biological, immunological events. Results: After intravenous injection, AGuIX accumulates tumors through enhanced permeability retention (EPR) effect, its specific properties allow persistence for several days. At cellular level, nanomedicine is internalized by endocytic processes mainly located cytoplasm, especially lysosomes. enhances effects radiotherapy (RT) at levels, starting radiation–matter interactions chemical stage reactive oxygen species (ROS) production, followed cascade biological events leading cell death immune response. Indeed, induces local increase radiation dose deposition emission Auger electrons, ROS generation. also impacts RT-induced mechanisms, including DNA damage such as apoptosis, autophagic death, ferroptosis. Last, combination RT stimulates antitumor response induction immunogenic (ICD), activation dendritic T cells, reprogramming tumor-associated macrophages (TAMs) into pro-inflammatory phenotype. Conclusions: nanoparticle (NP) intravenously administered pan-cancer potential due biodistribution strong ability amplify mechanisms.

Language: Английский

Autofluorescence cascade nanozyme catalyzes in vivo ROS scavenging for precisive anti-neuroinflammation therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163217 - 163217

Published: May 1, 2025

Nanoscale dosimetry for a radioisotope‐labeled metal nanoparticle using MCNP6.2 and Geant4

Medical Physics, Journal Year: 2024, Volume and Issue: 51(12), P. 9290 - 9302

Published: Sept. 3, 2024

Metal nanoparticles (MNPs) labeled with radioisotopes (RIs) are utilized as radio-enhancers due to their ability amplify the radiation dose in immediate vicinity. A thorough understanding of nanoscale dosimetry around MNPs enables effective application radiotherapy. However, still requires further investigation.

Language: Английский