Facile Synthesis of Dihydroisobenzofuran Derivatives Via a One-Pot Sequential Passerini-Azide/Ag(I)-Catalyzed Cyclization Process

Published: Jan. 1, 2024

A facile one-pot synthesis of dihydroisobenzofuran derivatives by Passerini-azide/Ag(I)-catalyzed cyclization sequence has been developed. The Passerini-azide reactions 2-(alkynyl)benzaldehydes, trimethylsilyl azide, and isocyanides gave tetrazole intermediates, which were transformed to the dihydroisobenzofurans in moderate good yields via Ag(I)-catalyzed 5-exo-dig reaction.

Language: Английский

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Facile synthesis of dihydroisobenzofuran derivatives via a one-pot sequential Passerini-azide/Ag(I)-catalyzed cyclization process

Tetrahedron, Journal Year: 2024, Volume and Issue: 158, P. 133984 - 133984

Published: April 13, 2024

Language: Английский

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Cascade Reaction of Enyne-Amides with Sulfur-Ylides for the Synthesis of Indole-Tethered 5-Oxaspiro[2.4]hept-6-ene Derivatives

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

An unexpected cascade reaction of enyne-amides with sulfur-ylides has been developed. This involves cycloisomerization, dearomatic cyclopropanation, ring-opening rearomatization, and subsequent differing from the common [2 + n] cyclization enyne-amides. A variety (spirocyclopropane)dihydrofuran derivatives have efficiently conveniently synthesized in a single vessel, exhibiting excellent diastereoselectivity good functional group tolerance.

Language: Английский

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Five-membered ring systems: Pyrroles and benzo analogs

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 173

Published: Jan. 1, 2024

Language: Английский

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