Recent advances in synthetic approaches for bioactive cinnamic acid derivatives

Beilstein Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 21, P. 1031 - 1086

Published: May 28, 2025

Cinnamic acid derivatives represent a significant class of biologically active compounds exhibiting broad spectrum activities, such as antifungal, antidengue, antimetastatic, antimicrobial, antibacterial, and anticancer properties. Their preparation has attracted considerable attention due to their versatile applications across the pharmaceutical, food, chemical sectors. This review elucidates functional groups cinnamic that are instrumental in rational design derivatives. A comprehensive representative recent advancements synthetic methodologies over past five years is presented, particularly emphasizing scaffolds bioactive The provides strategic overview alternative routes highlights latest innovations, including more efficient, highly selective, environmentally sustainable approaches. Given widespread incorporation framework various therapeutic agents, this delivers critical insights into molecular for hit-to-lead optimization, offering detailed strategies diverse modifications. By critically examining these methodologies, paper underscores role expanding utility addressing prevailing challenges.

Language: Английский

A One-Step Synthesis of Esters Via Modified Yamaguchi Esterification Mediated by Pivaloyl Anhydride

Published: Jan. 1, 2024

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Language: Английский