Synthetic Strategy for Unsymmetrical α-Fluoro-α′-aryl Ketones
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
α-Fluoro-α′-aryl
ketones
are
crucial
in
pharmaceuticals
and
agrochemicals.
However,
synthesizing
unsymmetrical
α-fluoro-α′-aryl
poses
regioselective
challenges.
This
study
presents
a
one-pot
aryl-oxy-fluorination
method
for
such
fluoro-aryl
ketones.
Using
ynamide,
aryl
boronic
acid,
F-source
under
Pd-catalysis,
this
efficiently
produces
wide
range
of
valuable
with
potential
applications.
Through
combination
control
experiments
DFT
studies,
we
proposed
reaction
mechanism
involving
situ
acetic
acid
formation.
Language: Английский
Regioselective syn-1,2-Hydroarylation of Internal Alkynes
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(24), P. 7168 - 7175
Published: Jan. 1, 2024
The
regioselective
hydro-functionalization
reaction
is
a
powerful
method
to
convert
readily
available
alkynes
into
structurally
diverse
olefins.
Language: Английский
A Precise Route to Tetrasubstituted Allyl Amines via Regioselective Dicarbofunctionalization of Masked Propargyl Amines
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(45), P. 9746 - 9751
Published: Nov. 7, 2024
Allyl
amines
are
vital
components
in
various
biologically
important
molecules
and
play
a
significant
role
their
function.
Presently,
most
methods
geared
toward
the
preparation
of
di-
trisubstituted
allyl
amines,
leaving
gap
for
development
more
versatile
approaches.
We
herein
describe
an
approach
to
yield
tetrasubstituted
through
palladium
(Pd)-catalyzed
regioselective
dicarbofunctionalization
masked
N-phthalimide-protected
propargyl
amines.
The
cationic
Pd-intermediate
conjunction
with
amine
exerts
collective
control
reaction
regioselectivity.
This
method
accommodates
wide
range
alkynes,
aryl
boronic
acids,
diazonium
salts
offering
direct
access
unusual
Language: Английский