An entry to spiro-fused sultams via electrochemical brominative ipso-annulation of N-aryl alkynyl sulphonamides DOI
Chada Raji Reddy,

Maramoni Shivudu,

Anjali Rathaur

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: unknown, P. 155330 - 155330

Published: Oct. 1, 2024

Language: Английский

Recent advances in the cyclization of para-quinone methides DOI
Xianping Liu,

Yining Ren,

Longzhi Zhu

et al.

Tetrahedron, Journal Year: 2023, Volume and Issue: 148, P. 133655 - 133655

Published: Oct. 9, 2023

Language: Английский

Citations

13
Iron-catalyzed one-pot tandem oxidation/acylation/dearomatization of biaryl ynones with benzyl alcohols: Access to diversified acylated spiro[5.5]trienones DOI

Dong Xia,

Yanfeng Miao,

Huimin Ji

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155469 - 155469

Published: Jan. 1, 2025

Language: Английский

Citations

0
Electrochemical benzylic deuteration of p-QMs enabling the synthesis of benzylic deuterated diarylmethanes DOI

Yunying Yan,

Jianjun Hao,

Yulin Peng

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(20), P. 4047 - 4051

Published: Jan. 1, 2024

Herein, electroreductive umpolung benzylic deuteration of p -QMs using cheap and easily accessible D 2 O as a deuterium source is reported.

Language: Английский

Citations

2
A one-pot Synthesis of 2,3-Dihydrobenzofurans, Benzofuran-2(3H)-ones, and Indoles via [4 + 1] Annulation Reaction of ortho-substituted para-Quinone Methides and Bromonitromethane DOI

Amol T. Savekar,

Vishal B. Karande,

Dattatray G. Hingane

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A facile one-pot synthesis of oxygen- and nitrogen-containing benzoheterocycles has been achieved through [4 + 1] annulation para -quinone methides, followed by an oxidation/elimination sequence.

Language: Английский

Citations

2
Recent advances in radical thiocyanation cyclization or spirocyclization reactions DOI

Qinqin Yan,

Shiliu Chen,

Jie Fan

et al.

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(46), P. 9112 - 9122

Published: Jan. 1, 2023

Organic thiocyanates are valuable biological moities and drug-building blocks. They can also transform effectively into thioethers, thiols, alkynyl thiocarbamates in synthetic chemistry. With respect to the merits of thiocyanates, many chemists our research team have developed diverse strategies access SCN-revised heterocycles/spirocycles via an effective radical cyclization process. Hence, this review article first describes importance/application thiocyanates. Subsequently, it summarizes reaction conditions, substrate scopes, plausible mechanism, respectively, excellent work stated above.

Language: Английский

Citations

6
Organocatalytic Vinylogous Michael Addition/Cyclization Cascade of 2‐Alkylidene Indane‐1,3‐diones with Enals: A Regio‐ and Stereocontrolled Diversity‐Oriented Route to Indane‐1,3‐dione Derivatives DOI Open Access

Jen‐Yu Kuan,

I‐Ting Chen,

Hsuan Lin

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(20), P. 3493 - 3504

Published: Aug. 26, 2023

Abstract A substrate‐dependent, regio‐ and stereocontrolled diversity‐oriented organocatalytic vinylogous Michael addition/cyclization cascade of 2‐alkylidene indane‐1,3‐diones with enals, using secondary amines as the catalyst, has been developed. This allows synthesis spiroindane‐1,3‐diones, tetrahydrofluoren‐9‐one derivatives, benzofused oxabicyclo[3.3.1]nonanes in a highly selective manner. Plausible catalytic pathways for formation these biologically interesting compounds were proposed. Density functional theory (DFT) calculations have clarified supported mechanisms how organocatalyst is able to activate enals 2‐hydroxycinnamaldehydes, directing C−C bond forming dienolates enabling derivatives.

Language: Английский

Citations

5
Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines DOI Creative Commons
Wanwan Wang, Lei Yu

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 458 - 458

Published: Jan. 17, 2024

The oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction diverse structural units and complex molecules in organic chemistry. This work reports an alkyl initiated 5-exo-trig biaryl ynones with 1,4-dihydropyridines to selectively synthesize indenones.

Language: Английский

Citations

1
Carbonylative Cyclization of Biaryl Enones with Aldehydes and Oxamic Acids DOI
Chada Raji Reddy, Dattahari H. Kolgave,

Sana Fatima

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(24), P. 4901 - 4911

Published: Jan. 1, 2024

An oxidative radical-promoted carbonylative cyclization strategy for the synthesis of phenanthren-9-(10

Language: Английский

Citations

1
Radical Cascade Annulation of Biphenyl Acrylamides to Dibenzoazepinones: Experimental and DFT Studies DOI

Raju Dupud,

Ramakrishnan Thushara,

Karthik Kumar Merugu

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(31)

Published: June 6, 2024

Abstract An efficient method for the conversion of biphenyl acrylamides to dibenzoazepinones with −SCF 3 incorporation is described. This operationally simple radical cascade reaction employs CAN as an oxidant and exhibits good functional group tolerance. Substrates featuring −OCH , −CH −Br or −Cl at para ‐position aromatic ring a preference ipso ‐cyclization due intervention DMSO in reaction. Density theory (DFT) calculations provide valuable insights into reaction's energetics product selectivity.

Language: Английский

Citations

1
Design and application of intramolecular arylogous nitroaldol condensation to access 2-aryl-benzofuran and -indole derivatives and formal synthesis of saprisartan DOI Creative Commons

Manyam Subbi Reddy,

Killari Satyam,

Surisetti Suresh

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(50), P. 37234 - 37239

Published: Jan. 1, 2024

An intramolecular arylogous nitroaldol condensation has been developed for the synthesis of benzoheterols under transition metal-free conditions and synthesized an advanced key intermediate saprisartan—thus constituting a formal synthesis.

Language: Английский

Citations

1