Base-mediated [4 + 3] annulation of α-halogen hydroximate with o-QMs: Facile access to 1, 4-benzoxazepine scaffold

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 136, P. 154911 - 154911

Published: Jan. 13, 2024

Language: Английский

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The Green Synthesis of 2‐Pyrrolin‐5‐ones from Bio‐renewable Glyoxal, Diketones and Amines

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(13)

Published: Feb. 21, 2024

Abstract Described herein is an effective and green reaction between diketones, amines bio‐renewable glyoxal, affording a wide range of 2‐pyrrolin‐5‐ones releasing water as the only byproduct. The features step‐economy, high efficiency, mild conditions, broad substrate scope, hazardous waste avoiding easy scale‐up. further transformation products aldehydes can be potentially applied for fluorescent dye synthesis.

Language: Английский

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Construction of 1,4‐Oxazepinones via a Cascade Aza‐Michael/SN2 Annulation of Trifluoromethyl Pyrazole‐derived Oxadienes with a‐Bromohydroxamates

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Abstract A highly efficient cascade aza‐MIRC (Michael Induced Ring Closure) reaction between trifluoromethylpyrazole (TFPZ)‐derived oxadienes and a ‐bromohydroxamates has been developed for the construction of 1,4‐oxazepinone derivatives. The proceeds smoothly under mild conditions via Aza‐Michael addition/intramolecular S N 2 sequence, features broad substrate scope, transition‐metal free, operational simplicity etc. utility versatile protocol was also demonstrated by gram‐scale valuable synthetic transformations.

Language: Английский

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Five-membered ring systems: Pyrroles and benzo analogs

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 173

Published: Jan. 1, 2024

Language: Английский

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